The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway

2021 ◽  
Author(s):  
Stéphane Zingue ◽  
Julia Cisilotto ◽  
Robinson Charly Mbe Fogang ◽  
Edwige Nana Tchoupang ◽  
Derek Tantoh Ndinteh ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Ethanolic Extract ◽  
Mitochondrial Pathway ◽  
Oxygen Species ◽  
Ethanolic Extract Of Propolis

Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: Involvement of mitochondrial pathway and reactive oxygen species

2009 ◽  
Vol 31 (2) ◽  
pp. 320-330 ◽  
Author(s):  
Martha Barba-Barajas ◽  
Georgina Hernández-Flores ◽  
José M. Lerma-Díaz ◽  
Pablo C. Ortiz-Lazareno ◽  
Jorge R. Domínguez-Rodríguez ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Polymorphonuclear Leukocytes ◽  
Reactive Oxygen ◽  
Mitochondrial Pathway ◽  
Oxygen Species ◽  
Induced Apoptosis

scholarly journals Ivalin Induces Mitochondria-Mediated Apoptosis Associated with the NF-κB Activation in Human Hepatocellular Carcinoma SMMC-7721 Cells

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3809
Author(s):  
Zhuo Han ◽  
Fang-yuan Liu ◽  
Shi-qi Lin ◽  
Cai-yun Zhang ◽  
Jia-hui Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Mitochondrial Pathway ◽  
Human Hepatocellular Carcinoma ◽  
Induction Effect ◽  
Oxygen Species ◽  
Microtubule Depolymerization ◽  
Apoptotic Effect

Ivalin, a natural compound isolated from Carpesium divaricatum, showed excellent microtubule depolymerization activities among human hepatocellular carcinoma in our previous work. Here, we investigated its functions on mitochondria-mediated apoptosis in hepatocellular carcinoma SMMC-7721 cells. DAPI (4′,6-diamidino-2-phenylindole) staining, annexin V-fluorexcein isothiocyanate (FITC) apoptosis detection, and western blotting were applied to explore the apoptotic effect of Ivalin. Next, the induction effect of Ivalin on the mitochondrial pathway was also confirmed via a series of phenomena including the damage of mitochondria membrane potential, mitochondria cytochrome c escape, cleaved caspase-3 induction, and the reactive oxygen species generation. In this connection, we understood that Ivalin induced apoptosis through the mitochondrial pathway and the overload of reactive oxygen species. Furthermore, we found that the activation of nuclear factor-κB (NF-κB) and subsequent p53 induction were associated with the apoptotic effect of Ivalin. These data confirmed that Ivalin might be a promising pro-apoptotic compound that can be utilized as a potential drug for clinical treatment.

scholarly journals Cissus quadrangularisLinn. Stem ethanolic extract liberates reactive oxygen species and induces mitochondria mediated apoptosis in KB cells

2015 ◽  
Vol 11 (44) ◽  
pp. 365 ◽  
Author(s):  
SnoberShabnam Mir ◽  
Saba Sheikh ◽  
Sahabjada Siddiqui ◽  
Anupam Dhasmana ◽  
Safia ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Ethanolic Extract ◽  
Oxygen Species ◽  
Kb Cells
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