The size-dependent apoptotic effect of titanium dioxide nanoparticles on endothelial cells by the intracellular pathway

2018 ◽  
Vol 33 (12) ◽  
pp. 1221-1228 ◽  
Author(s):  
Can Zeng ◽  
Yuqin Feng ◽  
Wuxiang Wang ◽  
Furong Zhou ◽  
Fen Liao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Size Dependent ◽  
Apoptotic Effect ◽  
Intracellular Pathway

The size‐dependent genotoxic potentials of titanium dioxide nanoparticles to endothelial cells

2019 ◽  
Vol 34 (11) ◽  
pp. 1199-1207 ◽  
Author(s):  
Fen Liao ◽  
Lingying Chen ◽  
Yuanfeng Liu ◽  
Dongting Zhao ◽  
Wenyi Peng ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Size Dependent

scholarly journals Curcumin inhibits activation induced by urban particulate material or titanium dioxide nanoparticles in primary human endothelial cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0188169 ◽  
Author(s):  
Angélica Montiel-Dávalos ◽  
Guadalupe Jazmin Silva Sánchez ◽  
Elizabeth Huerta-García ◽  
Cristhiam Rueda-Romero ◽  
Giovanny Soca Chafre ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Particulate Material ◽  
Human Endothelial Cells

scholarly journals Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway

2015 ◽  
Vol 4 (2) ◽  
pp. 385-398 ◽  
Author(s):  
Massimiliano G. Bianchi ◽  
Manfredi Allegri ◽  
Anna L. Costa ◽  
Magda Blosi ◽  
Davide Gardini ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Macrophage Activation ◽  
Titanium Dioxide Nanoparticles ◽  
Cytokine Secretion ◽  
No Production ◽  
Intracellular Pathway

TiO2nanoparticles enhance LPS-dependent NO production and cytokine secretion through a mechanism that involves TLR4-mediated p38-signalling and requires phagocytosis.

Aging-independent and size-dependent genotoxic response induced by titanium dioxide nanoparticles in mammalian cells

2019 ◽  
Vol 85 ◽  
pp. 94-106 ◽  
Author(s):  
Juan Wang ◽  
Jingjing Wang ◽  
Yun Liu ◽  
Yaguang Nie ◽  
Bo Si ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Mammalian Cells ◽  
Titanium Dioxide Nanoparticles ◽  
Size Dependent

scholarly journals Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells

2018 ◽  
Vol 20 (1) ◽  
pp. 35 ◽  
Author(s):  
Jie Tee ◽  
Li Ng ◽  
Hannah Koh ◽  
David Leong ◽  
Han Ho
Keyword(s):  
Endothelial Cells ◽  
Titanium Dioxide ◽  
Protein Kinase ◽  
Titanium Dioxide Nanoparticles ◽  
Portal Pressure ◽  
Endothelial Permeability ◽  
Drug Uptake ◽  
Sinusoidal Endothelial Cells ◽  
Tio2 Nps ◽  
Hepatic Sinusoidal Endothelial Cells

Liver sinusoidal endothelial cells (LSECs) represent the permeable interface that segregates the blood compartment from the hepatic cells, regulating hepatic vascular tone and portal pressure amidst changes in the blood flow. In the presence of pathological conditions, phenotypic changes in LSECs contribute to the progression of chronic liver diseases, including the loss of endothelial permeability. Therefore, modulating LSECs offers a possible way to restore sinusoidal permeability and thereby improve hepatic recovery. Herein, we showed that titanium dioxide nanoparticles (TiO2 NPs) could induce transient leakiness in primary human hepatic sinusoidal endothelial cells (HHSECs). Interestingly, HHSECs exposed to these NPs exhibited reduced protein kinase B (Akt) phosphorylation, an important protein kinase which regulates cell attachment. Using a 3D co-culture system, we demonstrated that TiO2 NPs diminished the attachment of HHSECs onto normal human hepatic cell LO2. To further illustrate the significance of leakiness in liver sinusoids, we showed that NP-induced leakiness promoted Sunitinib transport across the HHSEC layer, resulting in increased drug uptake and efficacy. Hence, TiO2 NPs have the potential to modulate endothelial permeability within the specialized sinusoidal endothelium, especially during events of fibrosis and occlusion. This study highlighted the possible use of inorganic NPs as a novel strategy to promote drug delivery targeting the diseased liver.

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