scholarly journals Thrombospondin-1 and microRNA-1 expression in response to multiwalled carbon nanotubes in alveolar epithelial cells

2017 ◽  
Vol 32 (5) ◽  
pp. 1596-1606 ◽  
Author(s):  
M. Pacurari ◽  
R. Kafoury ◽  
T. Turner ◽  
S. Taylor ◽  
P. B. Tchounwou
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Alveolar Epithelial Cells ◽  
Multiwalled Carbon ◽  
Alveolar Epithelial ◽  
Thrombospondin 1

Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes

2009 ◽  
Vol 23 (5) ◽  
pp. 333-344 ◽  
Author(s):  
Prabakaran Ravichandran ◽  
Adaikkappan Periyakaruppan ◽  
Bindu Sadanandan ◽  
Vani Ramesh ◽  
Joseph C. Hall ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Multiwalled Carbon ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells

2012 ◽  
Vol 26 (6) ◽  
pp. 831-840 ◽  
Author(s):  
Cinzia Lucia Ursini ◽  
Delia Cavallo ◽  
Anna Maria Fresegna ◽  
Aureliano Ciervo ◽  
Raffaele Maiello ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Multiwalled Carbon ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells

Induction of Apoptosis in Rat Lung Epithelial Cells by Multiwalled Carbon Nanotubes

2013 ◽  
Vol 27 (5) ◽  
pp. 286-286 ◽  
Author(s):  
Prabakaran Ravichandran ◽  
Adaikkappan Periyakaruppan ◽  
Bindu Sadanandan ◽  
Vani Ramesh ◽  
Joseph C. Hall ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Multiwalled Carbon ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

scholarly journals Assessment of Pulmonary Fibrogenic Potential of Multiwalled Carbon Nanotubes in Human Lung Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Anurag Mishra ◽  
Yon Rojanasakul ◽  
Bean T. Chen ◽  
Vincent Castranova ◽  
Robert R. Mercer ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Lung Fibrosis ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Multiwalled Carbon ◽  
Lung Epithelial

Multiwalled carbon nanotubes have been shown to possess unusual fibrogenic activityin vivoand are currently the focus of intense toxicological investigations. This study further determines the fibrogenic potential of well-dispersed MWCNT in human lung cell culture models and to develop a novel platform for understanding the cellular mechanisms of MWCNT-induced lung fibrosis. Survanta, a natural lung surfactant, showed effectiveness in dispersing agglomerates of MWCNT to fine structures similar in size to aerosolized one. At relevant low doses (0.002–0.2 μg/cm2), MWCNT exhibited a dose-dependent bio-effect on the human lung epithelial cells which is more pronounced in dispersed-MWCNT compared to non-dispersed form. Significantly elevated levels of fibrogenic mediators, such as transforming growth factor-β1 and matrix metalloprotienases-9 were observed in the dispersed-MWCNT treated lung epithelial cells. Based on previousin vivostudies showing that dispersed-MWCNT penetrated the interstitium and caused rapid interstitial fibrosis, we evaluated the potential direct interaction between lung fibroblasts and MWCNT. Direct stimulation of human lung fibroblast cell proliferation, collagen expression and fibroblast growth factor-2 were observed which suggests novel mechanisms of MWCNT-induced lung fibrosis. Our results indicate that the dispersion status of MWCNT determines their fibrogenic activity which is consistent within vivofindings.

Multiwalled carbon nanotubes activate NF-κB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells

APOPTOSIS ◽  
2010 ◽  
Vol 15 (12) ◽  
pp. 1507-1516 ◽  
Author(s):  
Prabakaran Ravichandran ◽  
Sudhakar Baluchamy ◽  
Bindhu Sadanandan ◽  
Ramya Gopikrishnan ◽  
Santosh Biradar ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Signaling Pathways ◽  
Multiwalled Carbon Nanotubes ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Multiwalled Carbon ◽  
Lung Epithelial

Alveolar epithelial cells type II show a high sensitivity to cigarette smoke extract

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Seehase ◽  
B Baron-Luehr ◽  
C Kugler ◽  
E Vollmer ◽  
T Goldmann
Keyword(s):  
Epithelial Cells ◽  
Cigarette Smoke ◽  
High Sensitivity ◽  
Cigarette Smoke Extract ◽  
Alveolar Epithelial Cells ◽  
Type Ii ◽  
Alveolar Epithelial
Sign in / Sign up

Export Citation Format

Share Document