Gestational and lactational exposition to Di-N-butyl-phthalate (DBP) increases inflammation and preneoplastic lesions in prostate of wistar rats after carcinogenicN-methyl-N-nitrosourea (MNU) plus testosterone protocol

2015 ◽  
Vol 31 (10) ◽  
pp. 1185-1195 ◽  
Author(s):  
André R. Peixoto ◽  
Talita M. Santos ◽  
Joyce Z. Brandt ◽  
Flávia K. Delella ◽  
Bianca F. Gonçalves ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Preneoplastic Lesions ◽  
Butyl Phthalate

scholarly journals Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats

2007 ◽  
Vol 115 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Milena Durando ◽  
Laura Kass ◽  
Julio Piva ◽  
Carlos Sonnenschein ◽  
Ana M. Soto ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Wistar Rats ◽  
Preneoplastic Lesions

Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats

2013 ◽  
Vol 33 (2) ◽  
pp. 148-163 ◽  
Author(s):  
OO Hamiza ◽  
MU Rehman ◽  
R Khan ◽  
M Tahir ◽  
AQ Khan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Wistar Rats ◽  
Aberrant Crypt Foci ◽  
Nuclear Antigen ◽  
Protective Mechanism ◽  
Antioxidant Enzyme Activities ◽  
Protective Agent ◽  
Preneoplastic Lesions ◽  
Markers Of Inflammation ◽  
Factor Α

Chemoprevention opens new window in the prevention of all types of cancers including colon cancer. Aloin, an anthracycline in plant pigment, can be utilized as a protective agent in cancer induction. In the present study, we have evaluated the chemopreventive efficacy of aloin against 1,2-dimethylhydrazine (DMH)-induced preneoplastic lesions in the colon of Wistar rats. DMH-induced aberrant crypt foci (ACF) and mucin-depleted foci (MDF) have been used as biomarkers of colon cancer. Efficacy of aloin against the colon toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, lipid peroxidation, ACF, MDF, histopathological changes, and expression levels of molecular markers of inflammation and tumor promotion. Aloin pretreatment ameliorates the damaging effects induced by DMH through a protective mechanism that involved reduction in increased oxidative stress enzymes ( p < 0.001), ACF, MDF, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6, proliferating cell nuclear antigen protein expression, and tumor necrosis factor-α ( p < 0.001) release. From the results, it could be concluded that aloin clearly protects against chemically induced colon toxicity and acts reasonably by inducing antioxidant level, anti-inflammatory and antiproliferative markers.

scholarly journals Omega-3 fatty acids reduce the development of preneoplasic lesions

2009 ◽  
Vol 22 (2) ◽  
pp. 237-244 ◽  
Author(s):  
Viviana Teixeira Henriques ◽  
Cristina Maria Ganns Chaves Dias ◽  
Sylvia do Carmo Castro Franceschini ◽  
Céphora Maria Sabarense ◽  
Neuza Maria Brunoro Costa ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Wistar Rats ◽  
Treated Group ◽  
Aberrant Crypt Foci ◽  
Colorectal Carcinogenesis ◽  
Control Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Preneoplastic Lesions ◽  
Male Wistar Rats

OBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.

Inhibitory effects of β-carotene on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model

1991 ◽  
Vol 12 (10) ◽  
pp. 1817-1822 ◽  
Author(s):  
F.S. Moreno ◽  
M.B.S.L. Rizzi ◽  
M.L.Z. Dagli ◽  
M.V.C. Penteado
Keyword(s):  
Wistar Rats ◽  
Inhibitory Effects ◽  
Preneoplastic Lesions ◽  
Β Carotene

Enhancing effects of mustard oil on preneoplastic hepatic foci development in Wistar rats

2003 ◽  
Vol 22 (2) ◽  
pp. 51-55 ◽  
Author(s):  
Yogeshwer Shukla ◽  
Annu Arora
Keyword(s):  
Wistar Rats ◽  
Dietary Habits ◽  
Liver Weight ◽  
Mustard Oil ◽  
Contributory Factor ◽  
Oil Consumption ◽  
Glutathione S Transferase ◽  
Preneoplastic Lesions ◽  
Altered Hepatic Foci ◽  
Glutamyl Transpeptidase

Dietary habits are known to be the major contributory factor in the development of cancer. Mustard oil, which is extensively used in India and elsewhere as a frying and cooking medium, is reported to induce an inflammatory response. The development of altered hepatic foci is an early carcinogenic change in rat liver in diethylnitrosamine (DEN)-induced hepatocarcinogenesis. In the present study, the development of preneoplastic lesions was observed following administration of mustard oil (0.5 mL/day for 8 weeks) in DEN-initiated and partially hepatomized Wistar rats. A significant decrease in the relative and absolute liver weight of mustard oil-exposed rats was recorded. The results revealed a significant increase in the number and area of placental glutathione S-transferase (GST-P) and g-glutamyl transpeptidase (GGT)-positive foci in mustard oil-administered animals. The GST-P and GGT-positive foci were more prominent in the animals given boiled (up to 3008C for 3 hours) mustard oil in comparison to the animals given fresh mustard oil. These results indicate the possible tumourigenic risk associated with mustard oil consumption.

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