Basic apoptotic and necrotic cell death in human liver carcinoma (HepG2) cells induced by synthetic azamacrocycle

2012 ◽  
Vol 29 (6) ◽  
pp. 605-611 ◽  
Author(s):  
Clement G. Yedjou ◽  
Musabbir A. Saeed ◽  
Md. Alamgir Hossain ◽  
Waneene Dorsey ◽  
Hongtao Yu ◽  
...  
Keyword(s):  
Cell Death ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Liver Carcinoma ◽  
Necrotic Cell Death ◽  
Necrotic Cell

Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain

APOPTOSIS ◽  
2006 ◽  
Vol 12 (4) ◽  
pp. 707-718 ◽  
Author(s):  
Min-Ju Kim ◽  
Soo-Jin Oh ◽  
Seong-Hoon Park ◽  
Hong-Jun Kang ◽  
Moo-Ho Won ◽  
...  
Keyword(s):  
Cell Death ◽  
Hepg2 Cells ◽  
Necrotic Cell Death ◽  
Necrotic Cell

Oleanolic acid rich solubilized triterpene extracts from mistletoe induce apoptotic and necrotic cell death of murine B16. F10 melanoma cells

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
CM Strüh ◽  
S Jäger ◽  
CM Schempp ◽  
T Jakob ◽  
A Scheffler ◽  
...  
Keyword(s):  
Cell Death ◽  
Oleanolic Acid ◽  
Melanoma Cells ◽  
Necrotic Cell Death ◽  
Necrotic Cell

NADPH Oxidases: New Players in TNF-Induced Necrotic Cell Death

2007 ◽  
Vol 26 (6) ◽  
pp. 769-771 ◽  
Author(s):  
Tom Vanden Berghe ◽  
Wim Declercq ◽  
Peter Vandenabeele
Keyword(s):  
Cell Death ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Nadph Oxidases

BNip3 is a mediator of TNF-induced necrotic cell death

APOPTOSIS ◽  
2010 ◽  
Vol 16 (2) ◽  
pp. 114-126 ◽  
Author(s):  
Jee-Youn Kim ◽  
Yong-Jun Kim ◽  
Sun Lee ◽  
Jae-Hoon Park
Keyword(s):  
Cell Death ◽  
Necrotic Cell Death ◽  
Necrotic Cell

scholarly journals Protein synthesis persists during necrotic cell death

2005 ◽  
Vol 168 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Xavier Saelens ◽  
Nele Festjens ◽  
Eef Parthoens ◽  
Isabel Vanoverberghe ◽  
Michael Kalai ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Synthesis ◽  
De Novo ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Proteolytic Activation ◽  
Double Stranded Rna ◽  
Molecular Events

Cell death is an intrinsic part of metazoan development and mammalian immune regulation. Whereas the molecular events orchestrating apoptosis have been characterized extensively, little is known about the biochemistry of necrotic cell death. Here, we show that, in contrast to apoptosis, the induction of necrosis does not lead to the shut down of protein synthesis. The rapid drop in protein synthesis observed in apoptosis correlates with caspase-dependent breakdown of eukaryotic translation initiation factor (eIF) 4G, activation of the double-stranded RNA-activated protein kinase PKR, and phosphorylation of its substrate eIF2-α. In necrosis induced by tumor necrosis factor, double-stranded RNA, or viral infection, de novo protein synthesis persists and 28S ribosomal RNA fragmentation, eIF2-α phosphorylation, and proteolytic activation of PKR are absent. Collectively, these results show that, in contrast to apoptotic cells, necrotic dying cells retain the opportunity to synthesize proteins.

Citreoviridin induces ROS-dependent autophagic cell death in human liver HepG2 cells

Toxicon ◽  
2015 ◽  
Vol 95 ◽  
pp. 30-37 ◽  
Author(s):  
Ya-Nan Liu ◽  
Yue-Xia Wang ◽  
Xiao-Fang Liu ◽  
Li-Ping Jiang ◽  
Guang Yang ◽  
...  
Keyword(s):  
Cell Death ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Autophagic Cell Death
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