Immunological validation of the pharmacological and anti‐allergic action of glycyrrhetinic acid from Glycyrrhizae Radix

2021 ◽  
Author(s):  
Shinsuke Hisaka ◽  
Sachiko Murase ◽  
Hayato Kishi ◽  
Mitsuhiko Nose
Keyword(s):  
Glycyrrhetinic Acid ◽  
Glycyrrhizae Radix

Separation and quantitative analysis of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in Glycyrrhizae Radix by gas/3-liquid chromatography

1985 ◽  
Vol 320 (2) ◽  
pp. 430-434 ◽  
Author(s):  
Sakae Amagaya ◽  
Etsuko Sugishita ◽  
Yukio Ogihara ◽  
Susumu Ogawa ◽  
Kenzo Okada ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Quantitative Analysis ◽  
Glycyrrhetinic Acid ◽  
Glycyrrhizae Radix

Biotransformation of Glycyrrhetinic Acid by Cunninghamella blakesleeana

2011 ◽  
Vol 8 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Yu-Juan QIN ◽  
Bing FENG ◽  
Xin-Bo SONG ◽  
Wen-Bin ZHOU ◽  
He-Shui YU ◽  
...  
Keyword(s):  
Glycyrrhetinic Acid ◽  
Cunninghamella Blakesleeana

scholarly journals Novel Carbon Dots Derived from Glycyrrhizae Radix et Rhizoma and Their Anti-Gastric Ulcer Effect

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1512
Author(s):  
Yuhan Liu ◽  
Meiling Zhang ◽  
Jinjun Cheng ◽  
Yue Zhang ◽  
Hui Kong ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Photoelectron Spectroscopy ◽  
Carbon Dots ◽  
High Performance ◽  
Raw264.7 Cells ◽  
Mice Model ◽  
X Ray ◽  
Glycyrrhizae Radix ◽  
Transmission Electron ◽  
High Resolution Tem

Glycyrrhizae Radix et Rhizoma (GRR) is one of the commonly used traditional Chinese medicines in clinical practice, which has been applied to treat digestive system diseases for hundreds of years. GRR is preferred for anti-gastric ulcer, however, the main active compounds are still unknown. In this study, GRR was used as precursor to synthesize carbon dots (CDs) by a environment-friendly one-step pyrolysis process. GRR-CDs were characterized by using transmission electron microscopy, high-resolution TEM, fourier transform infrared, ultraviolet-visible and fluorescence spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction and high-performance liquid chromatography. In addition, cellular toxicity of GRR-CDs was studied by using CCK-8 in RAW264.7 cells, and the anti-gastric ulcer activity was evaluated and confirmed using mice model of acute alcoholic gastric ulcer. The experiment confirmed that GRR-CDs were the spherical structure with a large number of active groups on the surface and their particle size ranged from 2 to 10 nm. GRR-CDs had no toxicity to RAW264.7 cells at concentration of 19.5 to 5000 μg/mL and could reduce the oxidative damage of gastric mucosa and tissues caused by alcohol, as demonstrated by restoring expression of malondialdehyde, superoxide dismutase and nitric oxide in serum and tissue of mice. The results indicated the explicit anti-ulcer activity of GRR-CDs, which provided a new insights for the research on effective material basis of GRR.

scholarly journals Development of Spanish Broom and Flax Dressings with Glycyrrhetinic Acid-Loaded Films for Wound Healing: Characterization and Evaluation of Biological Properties

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1192
Author(s):  
Angela Abruzzo ◽  
Concettina Cappadone ◽  
Valentina Sallustio ◽  
Giovanna Picone ◽  
Martina Rossi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Loading ◽  
Healing Process ◽  
In Vitro Release ◽  
Sodium Hyaluronate ◽  
Biological Properties ◽  
Glycyrrhetinic Acid ◽  
Wound Dressings ◽  
Biological Studies

The selection of an appropriate dressing for each type of wound is a very important procedure for a faster and more accurate healing process. So, the aim of this study was to develop innovative Spanish Broom and flax wound dressings, as alternatives to cotton used as control, with polymeric films containing glycyrrhetinic acid (GA) to promote wound-exudate absorption and the healing process. The different wound dressings were prepared by a solvent casting method, and characterized in terms of drug loading, water uptake, and in vitro release. Moreover, biological studies were performed to evaluate their biocompatibility and wound-healing efficacy. Comparing the developed wound dressings, Spanish Broom dressings with GA-loaded sodium hyaluronate film had the best functional properties, in terms of hydration ability and GA release. Moreover, they showed a good biocompatibility, determining a moderate induction of cell proliferation and no cytotoxicity. In addition, the wound-healing test revealed that the Spanish Broom dressings promoted cell migration, further facilitating the closure of the wound.

Structurally Modified Glycyrrhetinic Acid Derivatives as Anti-inflammatory Agents

2020 ◽  
pp. 104598
Author(s):  
Ming Bian ◽  
Dong Zhen ◽  
Qing-Kun Shen ◽  
Huan-Huan Du ◽  
Qian-Qian Ma ◽  
...  
Keyword(s):  
Glycyrrhetinic Acid ◽  
Anti Inflammatory

scholarly journals Antitumor component recognition from the Aconiti Lateralis Radix Praeparata and Glycyrrhizae Radix et Rhizoma herb pair extract by chemometrics and mean impact value

RSC Advances ◽  
2018 ◽  
Vol 8 (69) ◽  
pp. 39602-39610
Author(s):  
Hailiu Fan ◽  
Jianbang Xuan ◽  
Xinyun Du ◽  
Ningzhi Liu ◽  
Jianlan Jiang
Keyword(s):  
Experimental Data ◽  
Glycyrrhizae Radix ◽  
Car Model ◽  
Component Recognition

CAR models for the Fuzi–Gancao herb pair were constructed by BP, SVR, GA and PSO, and used to fit experimental data. The main active antitumor components were recognized from MIVs based on the optimal CAR model.

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