Cinnamomi Cortex and Scutellariae Radix in the Japanese herbal medicine Kampo saireito inhibit expression of iNOS through different mechanisms in hepatocytes

2020 ◽  
Vol 7 (1) ◽  
pp. 38-47
Author(s):  
Hideyuki Matsushima ◽  
Hidehiko Hishikawa ◽  
Hirokazu Miki ◽  
Masahiko Hatta ◽  
Richi Nakatake ◽  
...  
2002 ◽  
Vol 30 (01) ◽  
pp. 65-71 ◽  
Author(s):  
Hareka Watanabe ◽  
Takao Kobayashi ◽  
Meibou Tomii ◽  
Yuki Sekiguchi ◽  
Kazuhide Uchida ◽  
...  

There are studies reporting that some natural products containing melatonin. Sleep disturbance and nocturnal polyuria are related to abnormal biorhythm. It is possible that Kampo medicine may influence biorhythm. We therefore examined the symptoms and plasma melatonin of patients treated with Rokumi-gan, Hachimi-jio-gan, Gosha-jinki-gan and Seishinrenshi-in. Furthermore, the concentration of four kampo medicines and crude drugs making up these formulations were investigated. Diurnal plasma melatonin was not affected by Rokumi-gan, but tended to be lowered by treatment with Hachimi-jio-gan, Gosha-jinki-gan and Seishinrenshi-in. Melatonin was present in several extracts from crude drugs, namely Rehmanniae radix, Moutan cortex, Cinnamomi cortex, Aconiti tuber, Plantaginis semen, Scutellariae radix and Lycii radicis cortex.


2001 ◽  
Vol 16 (11) ◽  
pp. 1260-1266 ◽  
Author(s):  
Yoshinori Horie ◽  
Mikio Kajihara ◽  
Yoshiyuki Yamagishi ◽  
Hiroyuki Kimura ◽  
Hironao Tamai ◽  
...  

Maturitas ◽  
2015 ◽  
Vol 81 (1) ◽  
pp. 231
Author(s):  
Takashi Takeda ◽  
Kenji Tsuiji ◽  
Bin Li ◽  
Mari Tadakawa ◽  
Masami Shiina ◽  
...  

2012 ◽  
Vol 2 (3) ◽  
pp. 81-84 ◽  
Author(s):  
Yosuke Suzuki ◽  
Hiroki Itoh ◽  
Ryota Yamamura ◽  
Ryosuke Tatsuta ◽  
Yuhki Sato ◽  
...  

Author(s):  
Satomi Ozawa ◽  
Shigeyuki Mukudai ◽  
Mami Kaneko ◽  
Shota Kinoshita ◽  
Keiko Hashimoto ◽  
...  

2004 ◽  
Vol 1 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Xin Q. Wang ◽  
Takashi Takahashi ◽  
Shi-jie Zhu ◽  
Junji Moriya ◽  
Seiichiro Saegusa ◽  
...  

We aimed to evaluate the effect of a Japanese herbal medicine, Hochu-ekki-to (TJ-41), on daily activity in a murine model of chronic fatigue syndrome (CFS). CFS was induced by repeated injection ofBrucella abortus(BA) antigen every 2 weeks. TJ-41 was orally administered to mice in a dose of 500 mg/kg/day for 1 week before injecting BA and for 4 weeks thereafter. We evaluated daily running activity in mice receiving TJ-41 as compared with that in untreated mice. Survival of both mouse groups was also monitored during the observation period. Body weight (BW), spleen weight (SW), SW/ BW ratio and expression levels of interleukin-10 (IL-10) mRNA in spleen were determined in both groups at the time of sacrifice. The daily activity was significantly higher in the treated group than in the control. Two mice in the untreated group died 2 days after the second injection of BA, whereas no mice in the group treated with TJ-41 died. The SW and SW/BW ratio were significantly lower in the treated mice than in the control. Suppressed IL-10 mRNA levels were observed in the spleens of the mice treated with TJ-41. Our data suggest that Hochu-ekki-to might possess an inhibitory effect on the marked decrease in running activity following BA injection.


2014 ◽  
Vol 41 (9) ◽  
pp. 808-814 ◽  
Author(s):  
Kazuhiko Yamamura ◽  
Shiori Kato ◽  
Takahiro A. Kato ◽  
Yoshito Mizoguchi ◽  
Akira Monji ◽  
...  

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