Monocytes contribute to a pro‐healing response in 40 µm diameter uniform‐pore, precision‐templated scaffolds

2021 ◽  
Author(s):  
Nathan R. Chan ◽  
Billanna Hwang ◽  
Buddy D. Ratner ◽  
James D. Bryers
Keyword(s):  
Healing Response

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

Modulation Of Wound Healing Response In Chronic Irradiated Tissues

1993 ◽  
Vol 20 (3) ◽  
pp. 465-472 ◽  
Author(s):  
Thomas A. Mustoe ◽  
Beatriz H. Porras-Reyes
Keyword(s):  
Wound Healing ◽  
Healing Response ◽  
Wound Healing Response

Corneal Femtosecond Laser Keratotomy Results in Isolated Stromal Injury and Favorable Wound-Healing Response

2007 ◽  
Vol 48 (5) ◽  
pp. 2068 ◽  
Author(s):  
Christian Meltendorf ◽  
Guido J. Burbach ◽  
Jens Bu¨hren ◽  
Reinhold Bug ◽  
Christian Ohrloff ◽  
...  
Keyword(s):  
Wound Healing ◽  
Femtosecond Laser ◽  
Healing Response ◽  
Wound Healing Response

Decellularized kidney scaffold alters the healing response in chronic renal failure

2021 ◽  
Author(s):  
Fangfang Wang ◽  
Xiaolin Liu ◽  
Yaling Yu ◽  
Rui Zhang ◽  
Miaozhong Li ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Healing Response

Periodontal Repair in Surgically Created Intrabony Defects in Dogs: Influence of the Number of Bone Walls on Healing Response

2004 ◽  
Vol 75 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Chang-Sung Kim ◽  
Seong-Ho Choi ◽  
Jung-Kiu Chai ◽  
Kyoo-Sung Cho ◽  
Ik-Sang Moon ◽  
...  
Keyword(s):  
Intrabony Defects ◽  
Healing Response
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