scholarly journals Neuronal substrates alter the migratory responses of nonmyelinating Schwann cells to controlled brain‐derived neurotrophic factor gradients

2020 ◽  
Vol 14 (4) ◽  
pp. 609-621 ◽  
Author(s):  
Tanya Singh ◽  
Denise Robles ◽  
Maribel Vazquez
Keyword(s):  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Neuronal Substrates

Electrically induced brain-derived neurotrophic factor release from schwann cells

2014 ◽  
Vol 92 (7) ◽  
pp. 893-903 ◽  
Author(s):  
Beier Luo ◽  
Jinghui Huang ◽  
Lei Lu ◽  
Xueyu Hu ◽  
Zhuojing Luo ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Release

scholarly journals Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 ◽  
Vol 119 (1) ◽  
pp. 45-54 ◽  
Author(s):  
M Meyer ◽  
I Matsuoka ◽  
C Wetmore ◽  
L Olson ◽  
H Thoenen
Keyword(s):  
Sciatic Nerve ◽  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Time Course ◽  
Interleukin 1 ◽  
Brain Derived Neurotrophic Factor ◽  
Mrna Levels ◽  
Bdnf Mrna ◽  
Rat Sciatic Nerve ◽  
Cultured Schwann Cells

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are molecules which regulate the development and maintenance of specific functions in different populations of peripheral and central neurons, amongst them sensory neurons of neural crest and placode origin. Under physiological conditions NGF is synthesized by peripheral target tissues, whereas BDNF synthesis is highest in the CNS. This situation changes dramatically after lesion of peripheral nerves. As previously shown, there is a marked rapid increase in NGF mRNA in the nonneuronal cells of the damaged nerve. The prolonged elevation of NGF mRNA levels is related to the immigration of activated macrophages, interleukin-1 being the most essential mediator of this effect. Here we show that transsection of the rat sciatic nerve also leads to a very marked increase in BDNF mRNA, the final levels being even ten times higher than those of NGF mRNA. However, the time-course and spatial pattern of BDNF mRNA expression are distinctly different. There is a continuous slow increase of BDNF mRNA starting after day 3 post-lesion and reaching maximal levels 3-4 wk later. These distinct differences suggest different mechanisms of regulation of NGF and BDNF synthesis in non-neuronal cells of the nerve. This was substantiated by the demonstration of differential regulation of these mRNAs in organ culture of rat sciatic nerve and Schwann cell culture. Furthermore, using bioassays and specific antibodies we showed that cultured Schwann cells are a rich source of BDNF- and ciliary neurotrophic factor (CNTF)-like neurotrophic activity in addition to NGF. Antisera raised against a BDNF-peptide demonstrated BDNF-immunoreactivity in pure cultured Schwann cells, but not in fibroblasts derived from sciatic nerve.

Brain-derived neurotrophic factor suppresses anoikis-induced death of Schwann cells

2008 ◽  
Vol 444 (2) ◽  
pp. 143-147 ◽  
Author(s):  
Masao Koda ◽  
Yukio Someya ◽  
Yutaka Nishio ◽  
Ryo Kadota ◽  
Chikato Mannoji ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Brain-derived neurotrophic factor promotes nerve regeneration by activating the JAK/STAT pathway in Schwann cells

2016 ◽  
Vol 5 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Guiting Lin ◽  
Haiyang Zhang ◽  
Fionna Sun ◽  
Zhihua Lu ◽  
Amanda Reed-Maldonado ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Stat Pathway

Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF

Neuron ◽  
1991 ◽  
Vol 7 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Ann Acheson ◽  
Philip A. Barker ◽  
Ralph F. Alderson ◽  
Freda D. Miller ◽  
Richard A. Murphy
Keyword(s):  
Schwann Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor
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