Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

2020 ◽  
Vol 14 (2) ◽  
pp. 334-346 ◽  
Author(s):  
Marek Konop ◽  
Joanna Czuwara ◽  
Ewa Kłodzińska ◽  
Anna K. Laskowska ◽  
Dorota Sulejczak ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wound Dressing ◽  
Skin Wound ◽  
Diabetic Mice ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Wound Model ◽  
Thickness Skin

Silver Nanoparticles Preparation and their Effect on Full-thickness Skin Wound Healing in Rabbit Model

2018 ◽  
Vol 59 (1) ◽  
pp. 79
Author(s):  
Somaya Amer ◽  
Samir Nouh ◽  
Mahmoud Elkammar ◽  
Thanaa Shalaby ◽  
Ahmed Korittum
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Rabbit Model ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Keratin Scaffolds Containing Casomorphin Stimulate Macrophage Infiltration and Accelerate Full-Thickness Cutaneous Wound Healing in Diabetic Mice

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2554
Author(s):  
Marek Konop ◽  
Anna K. Laskowska ◽  
Mateusz Rybka ◽  
Ewa Kłodzińska ◽  
Dorota Sulejczak ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Diabetic Mice ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Impaired Wound Healing

Impaired wound healing is a major medical challenge, especially in diabetics. Over the centuries, the main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate the wound healing process. In this context, keratin-derived biomaterial is a promising candidate due to its biocompatibility and biodegradability. In this study, we evaluated an insoluble fraction of keratin containing casomorphin as a wound dressing in a full-thickness surgical skin wound model in mice (n = 20) with iatrogenically induced diabetes. Casomorphin, an opioid peptide with analgesic properties, was incorporated into keratin and shown to be slowly released from the dressing. An in vitro study showed that keratin-casomorphin dressing is biocompatible, non-toxic, and supports cell growth. In vivo experiments demonstrated that keratin-casomorphin dressing significantly (p < 0.05) accelerates the whole process of skin wound healing to the its final stage. Wounds covered with keratin-casomorphin dressing underwent reepithelization faster, ending up with a thicker epidermis than control wounds, as confirmed by histopathological and immunohistochemical examinations. This investigated dressing stimulated macrophages infiltration, which favors tissue remodeling and regeneration, unlike in the control wounds in which neutrophils predominated. Additionally, in dressed wounds, the number of microhemorrhages was significantly decreased (p < 0.05) as compared with control wounds. The dressing was naturally incorporated into regenerating tissue during the wound healing process. Applied keratin dressing favored reconstruction of more regular skin structure and assured better cosmetic outcome in terms of scar formation and appearance. Our results have shown that insoluble keratin wound dressing containing casomorphin supports skin wound healing in diabetic mice.

scholarly journals Pharmaceutical application of frog skin on full-thickness skin wound healing in mice

2013 ◽  
Vol 51 (12) ◽  
pp. 1600-1606 ◽  
Author(s):  
Mahere Rezazade Bazaz ◽  
Mohammad Mashreghi ◽  
Nasser Mahdavi Shahri ◽  
Mansour Mashreghi ◽  
Ahmad Asoodeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Frog Skin ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Pharmaceutical Application ◽  
Thickness Skin

Comparison of five dermal substitutes in full-thickness skin wound healing in a porcine model

Burns ◽  
2012 ◽  
Vol 38 (6) ◽  
pp. 820-829 ◽  
Author(s):  
Cécile Philandrianos ◽  
Lucile Andrac-Meyer ◽  
Serge Mordon ◽  
Jean-Marc Feuerstein ◽  
Florence Sabatier ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porcine Model ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Dermal Substitutes ◽  
Full Thickness Skin ◽  
Thickness Skin
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