scholarly journals Oligodendrocyte precursors gain Schwann cell‐like phenotype and remyelinate axons upon engraftment into peripheral nerves

2019 ◽  
Vol 13 (10) ◽  
pp. 1854-1860
Author(s):  
Ruifa Mi ◽  
Markus Tammia ◽  
Daniel Shinn ◽  
Ying Li ◽  
Russell Martin ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerves ◽  
Oligodendrocyte Precursors

scholarly journals Proteasome inhibition suppresses injury‐induced myelin ovoid formation and Schwann cell dedifferentiation in the peripheral nerves

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Hwan Tae Park ◽  
Hyun Kyoung Lee ◽  
Yoon Kyung Shin ◽  
Junyang Jung ◽  
Duk Joon Suh ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerves ◽  
Proteasome Inhibition ◽  
Cell Dedifferentiation

The geomagnetic field: a factor in cellular interactions?: I. Magnetism and Schwann cell-axon interaction in the peripheral nerves of the newborn rat

1987 ◽  
Vol 9 (4) ◽  
pp. 225-235 ◽  
Author(s):  
Khalid Shibib ◽  
Mario Brock ◽  
Georg Gosztonyi ◽  
Sergio N. Erne ◽  
Hans-Dieter Hahlbohm ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerves ◽  
Geomagnetic Field ◽  
Cellular Interactions ◽  
Newborn Rat ◽  
Cell Axon

scholarly journals Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin.

1982 ◽  
Vol 92 (3) ◽  
pp. 877-882 ◽  
Author(s):  
B D Trapp ◽  
R H Quarles
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerves ◽  
Minor Component ◽  
Integral Membrane Protein ◽  
Structural Protein ◽  
Adult Rat ◽  
Pns Myelin ◽  
Myelin Associated Glycoprotein ◽  
A Minor ◽  
Periaxonal Space

The myelin-associated glycoprotein (MAG) is an integral membrane protein (congruent to 100,000 mol wt) which is a minor component of purified peripheral nervus system (PNS) myelin. In the present study, MAG was localized immunocytochemically in 1-micrometer thick Epon sections of 7-d and adult rat peripheral nerves, and its localization was compared to that of the major structural protein (Po) of PNS myelin. To determine more precisely the localization of MAG, immunostained areas in 1 micrometer sections were traced on electron micrographs of identical areas from adjacently cut thin sections.l MAG was localized in periaxonal membranes. Schmidt-Lantermann incisures, paranodal membranes, and the outer mesaxon of PNS myelin sheaths. Compact regions of PNS myelin did not react with MAG antiserum. The results demonstrate MAG's presence in "'semi-compact" Schwann cell or myelin membranes that have a gap of 12-14 nm between extracellular leaflets and a spacing of 5 nm or more between cytoplasmic leaflets. In compact regions of the myelin sheath which do not contain MAG, the cytoplasmic leaflets are "fused" and form the major dense line, whereas the extracellular leaflets are separated by a 2.0 nm gap appearing as paired minor dense lines. Thus, it is proposed that MAG plays a role in maintaining the periaxonal space, Schmidt-Lantermann incisures, paranodal myelin loops, and outer mesaxon by preventing "complete" compaction of Schwann cell and myelin membranes. The presence of MAG in these locations also suggests that MAG may serve a function in regulating myelination in the PNS.

An electron microscope study of quantitative relationships between axon and Schwann cell sheath in myelinated fibres of peripheral nerves

1987 ◽  
Vol 175 (4) ◽  
pp. 423-430 ◽  
Author(s):  
E. Pannese ◽  
L. Rigamonti ◽  
P. Procacci ◽  
M. Ledda ◽  
G. Arcidiacono ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Schwann Cell ◽  
Peripheral Nerves ◽  
Microscope Study ◽  
Electron Microscope Study ◽  
Myelinated Fibres ◽  
Cell Sheath

scholarly journals Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

2015 ◽  
Vol 210 (1) ◽  
pp. 153-168 ◽  
Author(s):  
Jose A. Gomez-Sanchez ◽  
Lucy Carty ◽  
Marta Iruarrizaga-Lejarreta ◽  
Marta Palomo-Irigoyen ◽  
Marta Varela-Rey ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Peripheral Nerves ◽  
Wallerian Degeneration ◽  
Molecular Mechanisms ◽  
Demyelinating Disease ◽  
Cell Reprogramming ◽  
Selective Autophagy ◽  
Wide Range

Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide range of conditions that cause disease or injury to peripheral nerves, the cellular and molecular mechanisms that make Schwann cell–mediated myelin digestion possible have not been established. We report that Schwann cells degrade myelin after injury by a novel form of selective autophagy, myelinophagy. Autophagy was up-regulated by myelinating Schwann cells after nerve injury, myelin debris was present in autophagosomes, and pharmacological and genetic inhibition of autophagy impaired myelin clearance. Myelinophagy was positively regulated by the Schwann cell JNK/c-Jun pathway, a central regulator of the Schwann cell reprogramming induced by nerve injury. We also present evidence that myelinophagy is defective in the injured central nervous system. These results reveal an important role for inductive autophagy during Wallerian degeneration, and point to potential mechanistic targets for accelerating myelin clearance and improving demyelinating disease.

scholarly journals Disrupted Schwann cell–axon interactions in peripheral nerves of mice with altered L1-integrin interactions

2005 ◽  
Vol 30 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Kyoko Itoh ◽  
Shinji Fushiki ◽  
Hiroyuki Kamiguchi ◽  
Bernd Arnold ◽  
Peter Altevogt ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerves ◽  
Cell Axon
Sign in / Sign up

Export Citation Format

Share Document