scholarly journals Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues

2019 ◽  
Vol 13 (9) ◽  
pp. 1641-1650 ◽  
Author(s):  
Long Zhang ◽  
Wen‐Hui Wang ◽  
Jane Y. Jin ◽  
Simone Degan ◽  
Guo‐Qiang Zhang ◽  
...  
Keyword(s):  
Hair Follicle ◽  
De Novo ◽  
Dermal Papilla ◽  
Dermal Papilla Cells

Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis

Development ◽  
1992 ◽  
Vol 115 (2) ◽  
pp. 587-593 ◽  
Author(s):  
A.J. Reynolds ◽  
C.A. Jahoda
Keyword(s):  
Gene Expression ◽  
Hair Follicle ◽  
Hair Growth ◽  
De Novo ◽  
Dermal Papilla ◽  
Dermal Papilla Cells ◽  
Local Skin ◽  
Structural Arrangement ◽  
Adult Rat ◽  
Skin Epidermis

Adult rat pelage follicle dermal papilla cells induced follicle neogenesis and external hair growth when associated with adult footpad skin epidermis. They thus demonstrated a capacity to completely change the structural arrangement and gene expression of adult epidermis—an ability previously undocumented for cultured adult cells. Isolation chambers ensured that de novo follicle formation must have occurred by eliminating the possibility of cellular contributions, and/or inductive influences, from local skin follicles. These findings argue against previous suggestions of vibrissa follicle specificity, and imply that the potential for hair follicle induction may be common to all adult papilla cells.

Long-Term Culture of Mouse Vibrissal Dermal Papilla Cells and De Novo Hair Follicle Induction

2007 ◽  
Vol 13 (5) ◽  
pp. 975-982 ◽  
Author(s):  
Aki Osada ◽  
Tokuro Iwabuchi ◽  
Jiro Kishimoto ◽  
Tatsuo S. Hamazaki ◽  
Hitoshi Okochi
Keyword(s):  
Hair Follicle ◽  
De Novo ◽  
Dermal Papilla ◽  
Dermal Papilla Cells ◽  
Long Term Culture

scholarly journals Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 105
Author(s):  
Kristelle Hughes ◽  
Raimana Ho ◽  
Stéphane Greff ◽  
Gaëtan Herbette ◽  
Edith Filaire ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Pearson Correlation ◽  
Dermal Papilla ◽  
French Polynesia ◽  
Bioactive Molecules ◽  
Molecular Networks ◽  
Bioactive Metabolites ◽  
Hair Cycle ◽  
Bidens Pilosa ◽  
Dermal Papilla Cells

The term cosmetopoeia refers to the use of plants in folks’ cosmetics. The aerial parts of Bidens pilosa L., the leaves of Calophyllum inophyllum L. and the fruits of Fagraea berteroana A.Gray ex Benth are traditionally used in French Polynesia for hair and skin care. During the hair cycle, dermal papilla cells and their interaction with epithelial cells are essential to promote hair follicle elongation. The aim of our investigations was the identification of metabolites from these three plants and chemical families responsible for their hair growth activity. A bioactivity-based molecular network was produced by mapping the correlation between features obtained from LC-MS/MS data and dermal papilla cell proliferation, using the Pearson correlation coefficient. The analyses pointed out glycosylated flavonols and phenolic acids from B. pilosa and C. inophyllum, along with C-flavonoids, iridoids and secoiridoids from F. berteroana, as potential bioactive molecules involved in the proliferation of hair follicle dermal papilla cells. Our results highlight the metabolites of the plant species potentially involved in the induction of hair follicle growth and support the traditional uses of these plants in hair care.

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