Differentiation of the human liver progenitor cell line (HepaRG) on a microfluidic‐based biochip

2019 ◽  
Vol 13 (3) ◽  
pp. 482-494 ◽  
Author(s):  
Mi Jang ◽  
Astrid Kleber ◽  
Thomas Ruckelshausen ◽  
Ralf Betzholz ◽  
Andreas Manz
Keyword(s):  
Cell Line ◽  
Human Liver ◽  
Progenitor Cell ◽  
Liver Progenitor Cell ◽  
Progenitor Cell Line

scholarly journals Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels

Biomaterials ◽  
2014 ◽  
Vol 35 (19) ◽  
pp. 5110-5121 ◽  
Author(s):  
Melina M. Malinen ◽  
Liisa K. Kanninen ◽  
Anne Corlu ◽  
Helena M. Isoniemi ◽  
Yan-Ru Lou ◽  
...  
Keyword(s):  
Cell Line ◽  
Progenitor Cell ◽  
Organotypic Cultures ◽  
Nanofibrillar Cellulose ◽  
Liver Progenitor Cell ◽  
Progenitor Cell Line

Origin and characterization of a human bipotent liver progenitor cell line☆

2004 ◽  
Vol 126 (4) ◽  
pp. 1147-1156 ◽  
Author(s):  
Romain Parent ◽  
Marie-Jeanne Marion ◽  
Laetitia Furio ◽  
Christian Trépo ◽  
Marie-Anne Petit
Keyword(s):  
Cell Line ◽  
Progenitor Cell ◽  
Liver Progenitor Cell ◽  
Progenitor Cell Line

scholarly journals Liver Progenitor Cell Line HepaRG Differentiated in a Bioartificial Liver Effectively Supplies Liver Support to Rats with Acute Liver Failure

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38778 ◽  
Author(s):  
Geert A. A. Nibourg ◽  
Robert A. F. M. Chamuleau ◽  
Tessa V. van der Hoeven ◽  
Martinus A. W. Maas ◽  
An F. C. Ruiter ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Cell Line ◽  
Progenitor Cell ◽  
Bioartificial Liver ◽  
Liver Support ◽  
Liver Progenitor Cell ◽  
Progenitor Cell Line

Maturation-dependent gene expression in a conditionally transformed liver progenitor cell line

1998 ◽  
Vol 34 (3) ◽  
pp. 247-258 ◽  
Author(s):  
A. S. Fiorino ◽  
A. M. Diehl ◽  
H. Z. Lin ◽  
I. R. Lemischka ◽  
L. M. Reid
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Progenitor Cell ◽  
Liver Progenitor Cell ◽  
Progenitor Cell Line

Downregulation of c-kit (Stem Cell Factor Receptor) in Transformed Hematopoietic Precursor Cells by Stroma Cells

Blood ◽  
1999 ◽  
Vol 93 (2) ◽  
pp. 554-563 ◽  
Author(s):  
Christoph Heberlein ◽  
Jutta Friel ◽  
Christine Laker ◽  
Dorothee von Laer ◽  
Ulla Bergholz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Line ◽  
Stem Cell Factor ◽  
Progenitor Cell ◽  
Receptor Expression ◽  
General Mechanism ◽  
Ligand Interaction ◽  
Kit Ligand ◽  
Kit Receptor ◽  
Progenitor Cell Line

Abstract We show a dramatic downregulation of the stem cell factor (SCF) receptor in different hematopoietic cell lines by murine stroma. Growth of the human erythroid/macrophage progenitor cell line TF-1 is dependent on granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3). However, TF-1 cells clone and proliferate equally well on stroma. Independent stroma-dependent TF-1 clones (TF-1S) were generated on MS-5 stroma. Growth of TF-1S and TF-1 cells on stroma still requires interaction between c-kit (SCF receptor) and its ligand SCF, because antibodies against c-kit inhibit growth to less than 2%. Surprisingly, c-kit receptor expression (RNA and protein) was downregulated by 2 to 3 orders of magnitude in TF-1S and TF-1 cells grown on stroma. This stroma-dependent regulation of the kit receptor in TF-1 was also observed on exposure to kit ligand-negative stroma, thus indicating the need for heterologous receptor ligand interaction. Removal of stroma induced upregulation by 2 to 4 orders of magnitude. Downregulation and upregulation of c-kit expression could also be shown for the megakaryocytic progenitor cell line M-07e and was comparable to that of TF-1, indicating that stroma-dependent regulation of c-kit is a general mechanism. Downregulation may be an economic way to compensate for the increased sensitivity of the c-kit/ligand interaction on stroma. The stroma-dependent c-kit regulation most likely occurs at the transcriptional level, because mechanisms, such as splicing, attenuation, differential promoter usage, or mRNA stability, could be excluded.

An attempt to generate neurons from an astrocyte progenitor cell line FBD-104

2005 ◽  
Vol 53 (2) ◽  
pp. 104-115 ◽  
Author(s):  
Makoto Horiuchi ◽  
Yasuhiro Tomooka
Keyword(s):  
Cell Line ◽  
Progenitor Cell ◽  
Progenitor Cell Line
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