Cell-enrichment with olfactory ensheathing cells has limited local extra beneficial effects on nerve regeneration supported by the nerve guide Perimaix

2018 ◽  
Vol 12 (11) ◽  
pp. 2125-2137 ◽  
Author(s):  
Arne Hendrik Boecker ◽  
Ahmet Bozkurt ◽  
Bong Sung Kim ◽  
Haktan Altinova ◽  
Julian Tank ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Olfactory Ensheathing Cells ◽  
Beneficial Effects ◽  
Cell Enrichment ◽  
Ensheathing Cells

Although olfactory ensheathing cells have remarkable potential to sustain nerve regeneration, they cannot be applied to a severe vagus nerve section/resection model

2011 ◽  
Vol 43 (6) ◽  
pp. 919-920
Author(s):  
Alexandre Paviot ◽  
Nicolas Bon-Mardion ◽  
Célia Duclos ◽  
Jean-Paul Marie ◽  
Nicolas Guérout
Keyword(s):  
Vagus Nerve ◽  
Nerve Regeneration ◽  
Olfactory Ensheathing Cells ◽  
Nerve Section ◽  
Ensheathing Cells

Olfactory Ensheathing Cells Mediate Neuroplastic Mechanisms After Olfactory Training in Mouse Model

2019 ◽  
Vol 34 (2) ◽  
pp. 217-229 ◽  
Author(s):  
Boo-Young Kim ◽  
JuYeon Park ◽  
EuiJin Kim ◽  
ByungGuk Kim
Keyword(s):  
Olfactory System ◽  
Olfactory Receptors ◽  
Olfactory Ensheathing Cells ◽  
Control Group ◽  
Messenger Ribonucleic Acid ◽  
Beneficial Effects ◽  
Olfactory Neuroepithelium ◽  
Ensheathing Cells ◽  
Olfactory Training ◽  
Stimulation Of

Background Several studies have reported beneficial effects of olfactory training (OT) on the olfactory nervous system. However, the mechanisms underlying the regeneration of the olfactory system induced by OT are still under investigation. Objectives To determine the key mechanisms involved in the olfactory system recovery and to assess the neuroplastic effects of OT. Methods Thirty healthy female C57BL/6 mice were randomly allocated to 4 groups: control, n = 6; anosmia (no treatment), n = 8; OT, n = 8; and steroid treatment; n = 8. Except for the control group, mice were administered 3-methylindole. Anosmia was assessed using a food-finding test (FFT). The olfactory neuroepithelium was for histological examinations, gene ontology with pathway analyses, RNA, and protein studies. Results FFT was significantly reduced at 3 weeks in the OT mice versus steroids (78.27 s vs 156.83 s, P < .008) and controls (78.27 s vs 13.14 s, P < .003), although final outcome in the FFT was similar in these groups. Expression of olfactory and neurogenesis marker was higher in the olfactory neuroepithelium of the OT group than in the anosmia group without treatment. The mechanisms underlying olfactory regeneration might be related to early olfactory receptor stimulation, followed by neurotrophic factor stimulation of neuronal plasticity. Conclusion OT can improve olfactory function and accelerate olfactory recovery. The mechanisms underlying olfactory regeneration might be related to an initial stimulation of olfactory receptors followed by neurogenesis. Olfactory ensheathing cells might play an important role in olfactory regeneration following OT, based on the observed changes in messenger ribonucleic acid (mRNA) and protein expression, as well as the findings of the gene analysis.

Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair

2009 ◽  
Vol 1254 ◽  
pp. 10-17 ◽  
Author(s):  
Christine Radtke ◽  
Ayal A. Aizer ◽  
Samuel K. Agulian ◽  
Karen L. Lankford ◽  
Peter M. Vogt ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

scholarly journals The role of olfactory ensheating cells in regenerative medicine: review of the literature

2015 ◽  
Vol 5 (18) ◽  
pp. 75-80 ◽  
Author(s):  
Andreea Grosu-Bularda ◽  
Claudiu Manea ◽  
Ioan Lascar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Regenerative Medicine ◽  
Olfactory Ensheathing Cells ◽  
Beneficial Effects ◽  
Bulb Formation ◽  
Ensheathing Cells ◽  
Potential Therapeutic Role ◽  
The Central Nervous System

Abstract Olfactory ensheathing cells (OECs) join olfactory axons in their entrance to the central nervous system, representing a unique population of glial cells with functions in olfactory neurogenesis, axonal growth and olfactory bulb formation. Olfactory ensheathing cells have a great potential to induce repair for neural injuries, in central nervous system and peripheral nervous system, existing numerous experimental and clinical studies lately, reporting beneficial effects in anatomical and functional recovery. Studies are also conducted in order to establish possible pro-regenerative effects of the OECs, their potential in tissue repair and ability to modulate the immune system. The aim of this paper was to review the properties of olfactory ensheathing cells and their potential therapeutic role in regenerative medicine.

scholarly journals Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects

2019 ◽  
Vol 14 (1) ◽  
pp. 124 ◽  
Author(s):  
Yue Deng ◽  
Jing-Ping Fan ◽  
Jian Gu ◽  
He Xu ◽  
Ya-Ping Xu ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells
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