Injectable chitosan-platelet-rich plasma implants to promote tissue regeneration: in vitro properties, in vivo residence, degradation, cell recruitment and vascularization

2017 ◽  
Vol 12 (1) ◽  
pp. 217-228 ◽  
Author(s):  
A. Chevrier ◽  
V. Darras ◽  
G. Picard ◽  
M. Nelea ◽  
D. Veilleux ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Cell Recruitment ◽  
Regeneration In Vitro

Effects of the tetrahedral framework nucleic acids on the skeletal muscle regeneration in vitro and in vivo

2020 ◽  
Vol 4 (9) ◽  
pp. 2731-2743
Author(s):  
Yang Gao ◽  
Tianxu Zhang ◽  
Junyao Zhu ◽  
Dexuan Xiao ◽  
Mei Zhang ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Muscle Loss ◽  
Degenerative Diseases ◽  
Tetrahedral Framework ◽  
Volumetric Muscle Loss ◽  
Regeneration In Vitro

The challenges associated with muscle degenerative diseases and volumetric muscle loss (VML) emphasizes the prospects of muscle tissue regeneration.

Scaffolds containing chitosan, gelatin and graphene oxide for bone tissue regeneration in vitro and in vivo

2017 ◽  
Vol 104 ◽  
pp. 1975-1985 ◽  
Author(s):  
S. Saravanan ◽  
Anjali Chawla ◽  
M. Vairamani ◽  
T.P. Sastry ◽  
K.S. Subramanian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Regeneration In Vitro

scholarly journals Bioactive Sr(II)/Chitosan/Poly(ε-caprolactone) Scaffolds for Craniofacial Tissue Regeneration. In Vitro and In Vivo Behavior

Polymers ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 279 ◽  
Author(s):  
Itzia Rodríguez-Méndez ◽  
Mar Fernández-Gutiérrez ◽  
Amairany Rodríguez-Navarrete ◽  
Raúl Rosales-Ibáñez ◽  
Lorena Benito-Garzón ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Regeneration In Vitro ◽  
Craniofacial Tissue

A new bi-layered scaffold for osteochondral tissue regeneration: In vitro and in vivo preclinical investigations

2017 ◽  
Vol 70 ◽  
pp. 101-111 ◽  
Author(s):  
M. Sartori ◽  
S. Pagani ◽  
A. Ferrari ◽  
V. Costa ◽  
V. Carina ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Regeneration In Vitro ◽  
Osteochondral Tissue

Nonmulberry silk protein sericin blend hydrogels for skin tissue regeneration - in vitro and in vivo

2019 ◽  
Vol 137 ◽  
pp. 545-553 ◽  
Author(s):  
Sunaina Sapru ◽  
Subhayan Das ◽  
Mahitosh Mandal ◽  
Ananta K. Ghosh ◽  
Subhas C. Kundu
Keyword(s):  
Tissue Regeneration ◽  
Silk Protein ◽  
Skin Tissue ◽  
Regeneration In Vitro

Novel cellulose/hydroxyapatite scaffolds for bone tissue regeneration: In vitro and in vivo study

2018 ◽  
Vol 12 (5) ◽  
pp. 1195-1208 ◽  
Author(s):  
Povilas Daugela ◽  
Mindaugas Pranskunas ◽  
Gintaras Juodzbalys ◽  
Jolanta Liesiene ◽  
Odeta Baniukaitiene ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
In Vivo Study ◽  
Regeneration In Vitro

scholarly journals Systematic Review—The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair

2020 ◽  
Vol 21 (16) ◽  
pp. 5702 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Platelet Rich Plasma ◽  
Platelet Concentration ◽  
Volume Group ◽  
Scopus Database ◽  
Meta Analyses

The number of studies evaluating platelet-rich plasma (PRP) concentration has substantially grown in the last fifteen years. A systematic review on this field has been realized by evaluating in the identified studies the in vitro PRP concentration—also analyzing the platelet amount—and the in vivo PRP effects in tissue regeneration compared to any control. The protocol has been developed in agreement with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidelines. Multistep research of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database and Cochrane databases has permitted to identify articles on different concentrations of PRP in vitro and related in vivo impact for tissue repair. Of the 965 articles initially identified, 30 articles focusing on PRP concentration have been selected and, consequently, only 15 articles have been analyzed. In total, 40% (n = 6) of the studies were related to the fixed PRP Concentration Group used a fixed PRP concentration and altered the platelet concentration by adding the different volumes of the PRP (lysate) to the culture. This technique led to a substantial decrease in nutrition available at higher concentrations. Sixty percent (n = 9) of the studies were related to the fixed PRP Volume Group that used a fixed PRP-to-media ratio (Vol/Vol) throughout the experiment and altered the concentration within the PRP volume. For both groups, when the volume of medium (nutrition) decreases, a lower rate of cell proliferation is observed. A PRP concentration of 1.0 × 106 plt/μL, appears to be optimal thanks to the constant and plentiful capillary nutrition supply and rapid diffusion of growth factors that happen in vivo and it also respects the blood decree-law. The PRP/media ratio should provide a sufficient nutrition supply to prevent cellular starvation, that is, PRP ≤ 10% (Vol/Vol) and thus best mimic the conditions in vivo.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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