scholarly journals In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair

2017 ◽  
Vol 12 (2) ◽  
Author(s):  
Rose G. Long ◽  
Stijn G. Rotman ◽  
Warren W. Hom ◽  
Dylan J. Assael ◽  
Svenja Illien‐Jünger ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Block Copolymers ◽  
Annulus Fibrosus ◽  
Trimethylene Carbonate

scholarly journals Polyethylene Glycol and Poly (Trimethylene Carbonate) Block Copolymers for Annulus Fibrosus Repair have High Cytocompatibility, Restore Axial Range of Motion and have Some Herniation Risk

2016 ◽  
Vol 6 (1_suppl) ◽  
pp. s-0036-1582589-s-0036-1582589
Author(s):  
Rose Long ◽  
Stijn Rotman ◽  
Warren Hom ◽  
Dylan Assael ◽  
Svenja Illien-Junger ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Block Copolymers ◽  
Range Of Motion ◽  
Annulus Fibrosus ◽  
Trimethylene Carbonate

scholarly journals Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

2021 ◽  
Vol 22 (10) ◽  
pp. 5072
Author(s):  
Olakunle Oladimeji ◽  
Jude Akinyelu ◽  
Aliscia Daniels ◽  
Moganavelli Singh
Keyword(s):  
Polyethylene Glycol ◽  
Cancer Cell ◽  
Betulinic Acid ◽  
Targeted Delivery ◽  
Epigallocatechin Gallate ◽  
High Amplitude ◽  
Significant Inhibition ◽  
Mitochondrial Targeting ◽  
The Impact

Advances in nanomedicine have seen the adaptation of nanoparticles (NPs) for subcellular delivery for enhanced therapeutic impact and reduced side effects. The pivotal role of the mitochondria in apoptosis and their potential as a target in cancers enables selective induction of cancer cell death. In this study, we examined the mitochondrial targeted delivery of betulinic acid (BA) by the mitochondriotropic TPP+-functionalized epigallocatechin gallate (EGCG)-capped gold NPs (AuNPs), comparing the impact of polyethylene glycol (PEG) and poly-L-lysine-graft-polyethylene glycol (PLL-g-PEG) copolymer on delivery efficacy. This included the assessment of their cellular uptake, mitochondrial localization and efficacy as therapeutic delivery platforms for BA in the human Caco-2, HeLa and MCF-7 cancer cell lines. These mitochondrial-targeted nanocomplexes demonstrated significant inhibition of cancer cell growth, with targeted nanocomplexes recording IC50 values in the range of 3.12–13.2 µM compared to that of the free BA (9.74–36.31 µM) in vitro, demonstrating the merit of mitochondrial targeting. Their mechanisms of action implicated high amplitude mitochondrial depolarization, caspases 3/7 activation, with an associated arrest at the G0/G1 phase of the cell cycle. This nano-delivery system is a potentially viable platform for mitochondrial-targeted delivery of BA and highlights mitochondrial targeting as an option in cancer therapy.

scholarly journals Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 930
Author(s):  
Vasiliki Karava ◽  
Aggeliki Siamidi ◽  
Marilena Vlachou ◽  
Evi Christodoulou ◽  
Nikolaos D. Bikiaris ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
In Vitro Dissolution ◽  
Sem Images ◽  
Exterior Surface ◽  
Erosion Rates ◽  
Cytotoxicity Studies ◽  
Release Data ◽  
Long Acting

The present study evaluates the use of newly synthesized poly(l-lactic acid)-co-poly(butylene adipate) (PLA/PBAd) block copolymers as microcarriers for the preparation of aripiprazole (ARI)-loaded long acting injectable (LAI) formulations. The effect of various PLA to PBAd ratios (95/5, 90/10, 75/25 and 50/50 w/w) on the enzymatic hydrolysis of the copolymers showed increasing erosion rates by increasing the PBAd content, while cytotoxicity studies revealed non-toxicity for all prepared biomaterials. SEM images showed the formation of well-shaped, spherical MPs with a smooth exterior surface and no particle’s agglomeration, while DSC and pXRD data revealed that the presence of PBAd in the copolymers favors the amorphization of ARI. FTIR spectroscopy showed the formation of new ester bonds between the PLA and PBAd parts, while analysis of the MP formulations showed no molecular drug–polyester matrix interactions. In vitro dissolution studies suggested a highly tunable biphasic extended release, for up to 30 days, indicating the potential of the synthesized copolymers to act as promising LAI formulations, which will maintain a continuous therapeutic level for an extended time period. Lastly, several empirical and mechanistic models were also tested, with respect to their ability to fit the experimental release data.

scholarly journals Mesoporous Properties of Bioactive Glass Synthesized by Spray Pyrolysis with Various Polyethylene Glycol and Acid Additions

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 618
Author(s):  
Tzu-Yu Peng ◽  
Pei-Yun Tsai ◽  
May-Show Chen ◽  
Yuichi Mine ◽  
Shan-Hua Wu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Bioactive Glass ◽  
Spray Pyrolysis ◽  
Mesoporous Structure ◽  
High Specific Surface Area ◽  
Process Time ◽  
In Vitro Bioactivity ◽  
One Pot

Mesoporous bioactive glass (MBG) has a high specific surface area, promoting the reaction area, thereby improving the bioactivity; thus, MBG is currently gaining popularity in the biomaterial field. Spray pyrolysis (SP) is a one-pot process that has the advantages of shorter process time and better particle bioactivity, therefore, MBG was prepared by SP process with various polyethylene glycol (PEG, molecular weight ranged from 2000–12,000) and acid (HCl and CH3COOH) additions. In vitro bioactivity and mesoporous properties of the so-obtained MBG were investigated. The experimental results showed that all the MBG exhibited amorphous and mesoporous structure. Increasing the molecular weight of PEG can improve the mesoporous structure and bioactivity of MBG. Whereas optimized MBG was prepared with suitable concentration of PEG and CH3COOH. In the present work, MBG synthesized via spray pyrolysis by adding 5 g of PEG with a molecular weight of 12,000 and 50 mL of CH3COOH exhibited the best in vitro bioactivity and mesoporous structure.

scholarly journals Synthesis of ceramics in MOn/2-SiO2 systems through sol-gel processing under coexistence of polyethylene glycol and in vitro evaluation of their bioactivity

2008 ◽  
Vol 116 (1349) ◽  
pp. 56-62 ◽  
Author(s):  
Ill-Yong KIM ◽  
Masanobu KAMITAKAHARA ◽  
Giichiro KAWACHI ◽  
Koichi KIKUTA ◽  
Sung-Baek CHO ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Sol Gel ◽  
In Vitro Evaluation ◽  
Gel Processing

The Role of lnterleukin-1 on Proteoglycan Metabolism of Rabbit Annulus Fibrosus Cells Cultured In Vitro

Spine ◽  
1988 ◽  
Vol 13 (11) ◽  
pp. 1284-1290 ◽  
Author(s):  
MASAYUKI SHINMEI ◽  
TOSHIYUKI KIKUCHI ◽  
MASAAKI YAMAGISHI ◽  
YUTAKA SHIMOMURA
Keyword(s):  
Annulus Fibrosus ◽  
Cells Cultured

Polyimide-polyethylene glycol block copolymers: Synthesis, characterization, and initial evaluation as a biomaterial

1995 ◽  
Vol 6 (4) ◽  
pp. 313-323 ◽  
Author(s):  
Chandrashekhar P. Pathak ◽  
Amarpreet S. Sawhney ◽  
Christopher P. Quinn ◽  
Jeffrey A. Hubbell
Keyword(s):  
Polyethylene Glycol ◽  
Block Copolymers ◽  
Initial Evaluation
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