Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

2016 ◽  
Vol 11 (8) ◽  
pp. 2250-2260 ◽  
Author(s):  
Yun Gu ◽  
Zhenmeiyu Li ◽  
Jing Huang ◽  
Hongkui Wang ◽  
Xiaosong Gu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Peripheral Nerve ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

scholarly journals Natural Biomaterials as Instructive Engineered Microenvironments That Direct Cellular Function in Peripheral Nerve Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Rebecca Powell ◽  
Despoina Eleftheriadou ◽  
Simon Kellaway ◽  
James B. Phillips
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Peripheral Nerve ◽  
Cell Biology ◽  
Nerve Tissue ◽  
Cell Matrix ◽  
Nerve Tissue Engineering ◽  
Cellular Behaviour ◽  
Cell Matrix Interactions ◽  
Cellular Components

Nerve tissue function and regeneration depend on precise and well-synchronised spatial and temporal control of biological, physical, and chemotactic cues, which are provided by cellular components and the surrounding extracellular matrix. Therefore, natural biomaterials currently used in peripheral nerve tissue engineering are selected on the basis that they can act as instructive extracellular microenvironments. Despite emerging knowledge regarding cell-matrix interactions, the exact mechanisms through which these biomaterials alter the behaviour of the host and implanted cells, including neurons, Schwann cells and immune cells, remain largely unclear. Here, we review some of the physical processes by which natural biomaterials mimic the function of the extracellular matrix and regulate cellular behaviour. We also highlight some representative cases of controllable cell microenvironments developed by combining cell biology and tissue engineering principles.

scholarly journals Combining Gene and Stem Cell Therapy for Peripheral Nerve Tissue Engineering

2017 ◽  
Vol 26 (4) ◽  
pp. 231-238 ◽  
Author(s):  
Francesca Busuttil ◽  
Ahad A. Rahim ◽  
James B. Phillips
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Therapy ◽  
Peripheral Nerve ◽  
Stem Cell Therapy ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

scholarly journals Cyclic tensile stimulation enrichment of Schwann cell-laden auxetic hydrogel scaffolds towards peripheral nerve tissue engineering

2020 ◽  
Vol 195 ◽  
pp. 108982 ◽  
Author(s):  
Yi-Wen Chen ◽  
Kan Wang ◽  
Chia-Che Ho ◽  
Chia-Tze Kao ◽  
Hooi Yee Ng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Nerve Tissue ◽  
Hydrogel Scaffolds ◽  
Nerve Tissue Engineering

scholarly journals Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration

2015 ◽  
Vol 15 (6) ◽  
pp. 612-621 ◽  
Author(s):  
Lorena R. Lizarraga-Valderrama ◽  
Rinat Nigmatullin ◽  
Caroline Taylor ◽  
John W. Haycock ◽  
Frederik Claeyssens ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

scholarly journals Vascularization Strategies for Peripheral Nerve Tissue Engineering

2018 ◽  
Vol 301 (10) ◽  
pp. 1657-1667 ◽  
Author(s):  
Papon Muangsanit ◽  
Rebecca J. Shipley ◽  
James B. Phillips
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

In Vitro Evaluation of the Growth and Migration of Schwann Cells on Electrospun Silk Fibroin Nanofibers

2011 ◽  
Vol 175-176 ◽  
pp. 220-223 ◽  
Author(s):  
Ai Jun Hu ◽  
Bao Qi Zuo ◽  
Feng Zhang ◽  
Qing Lan ◽  
Huan Xiang Zhang
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Silk Fibroin ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering ◽  
And Migration ◽  
Silk Fibroin Nanofibers

Schwann cells (SCs) are primary structural and functional cells in peripheral nervous system and play a crucial role in peripheral nerve regeneration. Current challenge in peripheral nerve tissue engineering is to produce an implantable scaffold capable of bridging long nerve gaps and assist Scs in directing the growth of regenerating axons in nerve injury recovery. Electrospun silk fibroin nanofibers, fabricated for the cell culture in vitro, can provide such experiment support. Silk fibroin scaffolds (SFS) were fabricated with formic acid (FA), and the average fiber diameter was 305 ± 24 nm. The data from microscopic, immunohistochemical and scanning electron micrograph confirmed that the scaffold was beneficial to the adherence, proliferation and migration of SCs without exerting any significant cytotoxic effects on their phenotype. Thus, providing an experimental foundation accelerated the formation of bands of Bünger to enhance nerve regeneration. 305 nm SFS could be a candidate material for nerve tissue engineering.

Novel electrospun conduit based on polyurethane/collagen enhanced by nanobioglass for peripheral nerve tissue engineering

2022 ◽  
pp. 1-15
Author(s):  
Somayeh Tofighi Nasab ◽  
Nasim Hayati Roodbari ◽  
Vahabodin Goodarzi ◽  
Hossein Ali Khonakdar ◽  
Kourosh Mansoori ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering
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