Determination of critical size defect of minipig mandible

2009 ◽  
Vol 3 (8) ◽  
pp. 615-622 ◽  
Author(s):  
Jin-Ling Ma ◽  
Ju-Li Pan ◽  
Bao-Sheng Tan ◽  
Fu-Zhai Cui
Keyword(s):  
Critical Size ◽  
Critical Size Defect

Determination of critical size defect of minipig mandible

2015 ◽  
Vol 44 ◽  
pp. e258-e259
Author(s):  
J. Ma ◽  
J. Pan ◽  
B. Tan ◽  
F.Z. Cui
Keyword(s):  
Critical Size ◽  
Critical Size Defect

PTH1-34 improves devitalized allogenic bone graft healing in a murine femoral critical size defect

Injury ◽  
2021 ◽  
Author(s):  
Tito Rocha ◽  
Amanda S. Cavalcanti ◽  
Ana Carolina Leal ◽  
Rhayra B. Dias ◽  
Rafaela Sartore da Costa ◽  
...  
Keyword(s):  
Bone Graft ◽  
Critical Size ◽  
Critical Size Defect ◽  
Allogenic Bone ◽  
Graft Healing ◽  
Allogenic Bone Graft

scholarly journals The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect

2015 ◽  
Vol 33 (4) ◽  
pp. 488-495 ◽  
Author(s):  
Per Bosemark ◽  
Christina Perdikouri ◽  
Mea Pelkonen ◽  
Hanna Isaksson ◽  
Magnus Tägil
Keyword(s):  
Critical Size ◽  
Critical Size Defect ◽  
Induced Membrane ◽  
Membrane Technique ◽  
Induced Membrane Technique ◽  
Synthetic Scaffold

Histologic Evaluation of Osseous Regeneration Following Combination Therapy With Platelet-Rich Plasma and Bio-Oss in a Rat Calvarial Critical-Size Defect Model

2015 ◽  
Vol 41 (5) ◽  
pp. 543-549 ◽  
Author(s):  
Philip J. DeNicolo ◽  
M. Kelly Guyton ◽  
Michael F. Cuenin ◽  
Steven D. Hokett ◽  
Mohamed Sharawy ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Growth ◽  
Critical Size ◽  
Close Contact ◽  
Platelet Rich Plasma ◽  
Critical Size Defect ◽  
Histologic Evaluation ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Stain ◽  
Osseous Regeneration

Platelet-rich plasma (PRP) is an autogenous source of growth factors shown to facilitate human bone growth. Bio-Oss, an osteoconductive xenograft, is used clinically to regenerate periodontal defects, restore dental alveolar ridges, and facilitate sinus-lift procedures. The purpose of this study was to analyze whether a combination of PRP and Bio-Oss would enhance bone regeneration better than either material alone. PRP and/or Bio-Oss were administered in an 8-mm critical-size defect (CSD) rat calvarial model of bone defect between 2 polytetrafluoroethylene membranes to prevent soft tissue incursion. Eight weeks after the induction of the CSD, histologic sections were stained with hematoxylin and eosin stain and analyzed via light microscopy. Qualitative analyses revealed new bone regeneration in all 4 groups. The Bio-Oss and PRP plus Bio-Oss groups demonstrated greater areas of closure in the defects than the control or PRP-only groups because of the space-maintaining ability of Bio-Oss. The groups grafted with Bio-Oss showed close contact with new bone growth throughout the defects, suggesting a stronger graft. The use of PRP alone or in combination with Bio-Oss, however, did not appear to enhance osseous regeneration at 8 weeks. Areas grafted with Bio-Oss demonstrated greater space-maintaining capacity than controls, and PRP was an effective vehicle for placement of the Bio-Oss. However, at 8 weeks this study was unable to demonstrate a significant advantage of using PRP plus Bio-Oss over using Bio-Oss alone.

scholarly journals Mandible Biomechanics and Continuously Erupting Teeth: A New Defect Model for Studying Load-Bearing Biomaterials

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 730
Author(s):  
Jonathan Z. Baskin ◽  
Brandon M. White ◽  
Amit Vasanji ◽  
Thomas E. Love ◽  
Steven J. Eppell
Keyword(s):  
Critical Size ◽  
Supporting Evidence ◽  
Defect Model ◽  
Post Intervention ◽  
Critical Size Defect ◽  
Load Bearing ◽  
Tooth Structure ◽  
Incisor Growth ◽  
Apparent Relationship ◽  
Mandible Defect

Animals with elodont dentition and unfused mandible symphyses are hypothesized to have symmetric incisor morphology. Since these animals maintain their teeth by gnawing, they may provide physiologic feedback on mechanical function when unilateral mandible defects are created that manifest as ipsilateral changes in tooth structure. This defect model would potentially generate important information on the functional/mechanical properties of implants. Rats’ and rabbits’ mandibles and teeth are analyzed with µCT at baseline and post-intervention (n = 8 for each). Baseline incisors were compared. In a unilateral mandible pilot study, defects—ranging from critical size defect to complete ramus osteotomies—were created to assess effect on dentition (rats, n = 7; rabbits, n = 6). Within 90% confidence intervals, animals showed no baseline left/right differences in their incisors. There are apparent dental changes associated with unilateral defect type and location. Thus, at baseline, animals exhibit statistically significant incisor symmetry and there is an apparent relationship between mandible defect and incisor growth. The baseline symmetry proven here sets the stage to study the degree to which hemi-mandible destabilizing procedures result in measurable & reproducible disruption of dental asymmetry. In a validated model, an implant designed to function under load that prevents incisor asymmetry would provide supporting evidence that the implant has clinically useful load-bearing function.

Sign in / Sign up

Export Citation Format

Share Document