scholarly journals Local delivery of allogeneic bone marrow and adipose tissue-derived mesenchymal stromal cells for cutaneous wound healing in a porcine model

2013 ◽  
Vol 10 (2) ◽  
pp. E90-E100 ◽  
Author(s):  
Summer E. Hanson ◽  
Kyle R. Kleinbeck ◽  
David Cantu ◽  
Jaeyhup Kim ◽  
Michael L. Bentz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Adipose Tissue ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Porcine Model ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Lynn M Pezzanite ◽  
Lisa A Fortier ◽  
Douglas F Antczak ◽  
Jennifer M Cassano ◽  
Margaret M Brosnahan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Allogeneic Bone Marrow ◽  
Antibody Responses ◽  
Allogeneic Bone

scholarly journals Allogeneic Bone Marrow–Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn’s Disease

2015 ◽  
Vol 149 (4) ◽  
pp. 918-927.e6 ◽  
Author(s):  
Ilse Molendijk ◽  
Bert A. Bonsing ◽  
Helene Roelofs ◽  
Koen C.M.J. Peeters ◽  
Martin N.J.M. Wasser ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Perianal Fistulas

scholarly journals Tu1227 Treatment of Refractory Crohn's Disease With Allogeneic, Bone Marrow-Derived Adult Mesenchymal Stromal Cells

2012 ◽  
Vol 142 (5) ◽  
pp. S-779
Author(s):  
Renate Schmelz ◽  
Stefan Brueckner ◽  
Jana Babatz ◽  
Katja Richter ◽  
Nadine Muench ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone

scholarly journals P363 Locally injected allogeneic bone marrow-derived mesenchymal stromal cells for the treatment of refractory proctitis: clinical results of a phase IIa trial

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S381-S381
Author(s):  
L Ouboter ◽  
M Barnhoorn ◽  
M van Pel ◽  
J J Zwaginga ◽  
L Hawinkels ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adverse Events ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Experimental Colitis ◽  
Clinical Results ◽  
Fecal Calprotectin ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Mayo Score

Abstract Background Ulcerative proctitis (UP) can be refractory to treatment, which calls for development of new (local) therapies. Local injection of mesenchymal stromal cells (MSCs) has shown beneficial effects in patients with fistulizing Crohn’s disease and promising results have been obtained when MSCs were locally injected in the bowel of mice with experimental colitis. Our primary aim was to determine the safety, feasibility and tolerability of endoscopically injected allogeneic bone marrow-derived MSCs (bmMSCs) in UP patients. Methods UP patients with endoscopic Mayo score (EMS) 2 or 3, who failed on both rectal 5-ASA and corticosteroids for at least 4 weeks, were eligible for inclusion (EudraCT number 2017-003524-75). Rectal therapies were stopped 2 weeks prior to baseline, but other medication was kept stable until at least 6 weeks after MSC injection. MSCs were locally injected in 4 quadrants of the inflamed rectal submucosa if the inflammation was limited to 7 cm. If the length of inflammation was >7 cm, MSCs were injected in another 4 quadrants more proximally as well. Patients in the first cohort (n=7) were treated with 5*106 MSCs/spot and in the second cohort (n=6) with 10*106MSCs/spot. Adverse events, full Mayo score, fecal calprotectin (FCP), histologic activity (Geboes score [GS]) and quality of life (sIBDQ), were assessed at week 0, 2, 6, 12, and 24, and evaluated by non-parametric paired statistical analyses. Results All reported adverse events were minor, no patients required interventions and no feasibility issues were reported. Median[interquartile range (IQR)] full Mayo score was 11[9.5-12] at baseline, 9[8-11] at week 2 (p=0.003), 8[6-10] at week 6 (p=0.001), and 4[1.5-7] at week 24 (p<0.001). The FCP improved in 9/13 patients at week 2, in 6/13 patients at week 6 and in 11/13 patients at week 24 compared to baseline. The EMS at baseline was 3 (n=10 patients) and 2 (n=3 patients) and improved in some patients at week 2 and 6 (NS). At week 24 the EMS was 3 (n=2), 2 (n=4), 1 (n=5) and 0 (n=2)(p=0.002). The median[IQR] GS decreased after 6 weeks (7(6.5-12.5);p=0.09) and 24 weeks (4[2-8];p=0.01) compared to baseline (10[6.5-12.5]). Median[IQR] sIBDQ showed improvement during follow-up; week 2 (45[37.5-52];p=0.1), week 6 (47[42.50-55];p=0.02), week 12 (59[39.50-62];p=0.001) and week 24 (56[44.50-63.50];p=0.001) compared to baseline (41[34-49,50]). No dose- response effects were observed in our study when comparing cohort 1 and 2. Conclusion Local administration of allogeneic bmMSCs appears safe, tolerable and feasible for the treatment of refractory UP, and shows encouraging indications of clinical efficacy. Further mechanistic and immunological analyses are currently being performed.

Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote the Regeneration of Injured Skeletal Muscle without Differentiation into Myofibers

2004 ◽  
Vol 10 (7-8) ◽  
pp. 1093-1112 ◽  
Author(s):  
Koji Natsu ◽  
Mitsuo Ochi ◽  
Yu Mochizuki ◽  
Hiroki Hachisuka ◽  
Shinobu Yanada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone

Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote the Regeneration of Injured Skeletal Muscle without Differentiation into Myofibers

2004 ◽  
Vol 10 (7) ◽  
pp. 1093-1112 ◽  
Author(s):  
Koji Natsu ◽  
Mitsuo Ochi ◽  
Yu Mochizuki ◽  
Hiroki Hachisuka ◽  
Shinobu Yanada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone
Sign in / Sign up

Export Citation Format

Share Document