Development of poly(lactide-co-glycolide) scaffold-impregnated small intestinal submucosa with pores that stimulate extracellular matrix production in disc regeneration

2012 ◽  
Vol 8 (4) ◽  
pp. 279-290 ◽  
Author(s):  
Soon Hee Kim ◽  
Jeong Eun Song ◽  
Dongwon Lee ◽  
Gilson Khang
Keyword(s):  
Extracellular Matrix ◽  
Small Intestinal Submucosa ◽  
Disc Regeneration ◽  
Extracellular Matrix Production ◽  
Matrix Production ◽  
Small Intestinal ◽  
Intestinal Submucosa

Mechanical Characterization of the Decellularized Porcine Small Intestinal Submucosa Extracellular Matrix

2013 ◽  
Author(s):  
Shijia Zhao ◽  
Linxia Gu ◽  
James M. Hammel ◽  
Haili Lang
Keyword(s):  
Mechanical Properties ◽  
Extracellular Matrix ◽  
Mechanical Response ◽  
Mechanical Characterization ◽  
Small Intestinal Submucosa ◽  
Trade Name ◽  
Porcine Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

In this work, the decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM), obtained from the commercial product under the trade name of CorMatrix, were tested in uniaxial tension. Preconditioning under cyclic loading of 2 N was conducted to stabilize the mechanical response of the tissue. The influence of rehydration time on the mechanical properties of the tissue was evaluated. Results suggested that the stiffness of SIS-ECM decreased with longer rehydration time. Considering the application of CorMatrix in pericardial closure, the native pericardium samples were also tested. The comparison indicated that the native pericardium is softer than rehydrated CorMatrix. This work can facilitate the surgeons to better choose the appropriate rehydration time when conducting the extracardiac implantations, such as pericardial reconstruction, pericardial closure, etc.

Small Intestinal Submucosa: A Tissue-Derived Extracellular Matrix That Promotes Tissue-Specific Growth and Differentiation of Cells in Vitro

1998 ◽  
Vol 4 (2) ◽  
pp. 157-174 ◽  
Author(s):  
Sherry L. Voytik-Harbin ◽  
Andrew O. Brightman ◽  
Beverly Z. Waisner ◽  
J. Paul Robinson ◽  
Carlton H. Lamar
Keyword(s):  
Extracellular Matrix ◽  
Specific Growth ◽  
Small Intestinal Submucosa ◽  
Tissue Specific ◽  
Small Intestinal ◽  
Intestinal Submucosa

scholarly journals Small Intestinal Submucosa as a Potential Bioscaffold for Intervertebral Disc Regeneration

Spine ◽  
2006 ◽  
Vol 31 (21) ◽  
pp. 2423-2430 ◽  
Author(s):  
Catherine Le Visage ◽  
Shu-Hua Yang ◽  
Leena Kadakia ◽  
Ann N. Sieber ◽  
John P. Kostuik ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Small Intestinal Submucosa ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
Small Intestinal ◽  
Intestinal Submucosa

Effect of the αGal Epitope on the Response to Small Intestinal Submucosa Extracellular Matrix in a Nonhuman Primate Model

2009 ◽  
Vol 15 (12) ◽  
pp. 3877-3888 ◽  
Author(s):  
Kerry A. Daly ◽  
Ann M. Stewart-Akers ◽  
Hidetaka Hara ◽  
Mohamed Ezzelarab ◽  
Cassandra Long ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Nonhuman Primate ◽  
Small Intestinal Submucosa ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Small Intestinal ◽  
Intestinal Submucosa

Histological analysis of failed submucosa patches in congenital cardiac surgery

2019 ◽  
Vol 27 (6) ◽  
pp. 459-463
Author(s):  
Paul Philipp Heinisch ◽  
Yara Banz ◽  
Bettina Langhammer ◽  
Evelyn Stocker ◽  
Gabor Erdoes ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Small Intestinal Submucosa ◽  
Initial Surgery ◽  
Valve Reconstruction ◽  
Small Intestinal ◽  
Intestinal Submucosa ◽  
Matrix Patches

Objective Porcine small intestinal submucosa extracellular matrix is a biological substitute used in cardiovascular surgery to correct congenital heart defects. Previous studies with this material have shown satisfactory results. In contrast, there are singular reports of patch-associated complications with CorMatrix small intestinal submucosa extracellular matrix. We report the histopathological findings of explanted extracellular matrix patches that were removed because of early failure in patients with congenital heart defects. Methods Explanted patch materials from 4 patients (aged 9 months to 41 years), who underwent reoperation due to early patch failure, were analyzed. Initial surgery comprised one aortic valve reconstruction, one pulmonary valve reconstruction, one atrioventricular septal defect repair, and one aortic arch enlargement. The interval between operations ranged from 69 to 553 days. Results Residual extracellular matrix patch material was evident at explantation in all cases and presented as a structured eosinophilic and anucleate specimen. In two cases, a local focus of scarring and pseudocartilaginous transformation with evidence of calcification was found. There was no evidence of absorption of patch material in any case, nor repopulation by organized tissue formation. Conclusions Histologic examination of explanted extracellular matrix patches showed no evidence of resorption or relevant repopulation with resident cells nor formation of functional tissue structures. In contrast, a mixed chronic inflammatory infiltration, early signs of calcification, and scarring as well as focal pseudocartilaginous transformation were found. Considering recent reports, close follow-up of patients with extracellular matrix patches is recommended to evaluate the performance of this novel material and detect potential problems.

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