scholarly journals Mechanical compression of articular cartilage induces chondrocyte proliferation and inhibits proteoglycan synthesis by activation of the ERK pathway: implications for tissue engineering and regenerative medicine

2009 ◽  
Vol 3 (2) ◽  
pp. 107-116 ◽  
Author(s):  
James A. Ryan ◽  
Eric A. Eisner ◽  
Grayson DuRaine ◽  
Zongbing You ◽  
A. Hari Reddi
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Proteoglycan Synthesis ◽  
Erk Pathway ◽  
Mechanical Compression ◽  
Chondrocyte Proliferation

scholarly journals Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articular cartilage and intervertebral disc tissue engineering

2010 ◽  
Vol 222 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Stephen M. Richardson ◽  
Judith A. Hoyland ◽  
Reza Mobasheri ◽  
Constanze Csaki ◽  
Mehdi Shakibaei ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Intervertebral Disc ◽  
Disc Tissue

scholarly journals TISSUE ENGINEERING AND REGENERATIVE MEDICINE TECHNOLOGIES IN THE TREATMENT OF ARTICULAR CARTILAGE DEFECTS

2017 ◽  
Vol 18 (4) ◽  
pp. 102-122
Author(s):  
Yu. B. Basok ◽  
V. I. Sevastianov
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Industrial Society ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
Limited Capacity ◽  
Joint Cartilage ◽  
Articular Cartilage Defects ◽  
Stimulation Of

Some of the most pressing health problems of the industrial society are the damage and degeneration of articular cartilage associated with the limited capacity of tissues to regenerate. The review describes the existing and developing technologies for the recovery and replacement of damaged joint cartilage tissue. The results obtained are analyzed covering two major areas: the stimulation of regeneration of damaged cartilage tissue and the growing of cartilage tissue elements in bioreactors.

Marine origin materials on biomaterials and advanced therapies to cartilage tissue engineering and regenerative medicine

2021 ◽  
Author(s):  
Duarte Nuno Carvalho ◽  
Rui Reis ◽  
T. H. Silva
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Cartilage Tissue Engineering ◽  
The Body ◽  
Cartilage Tissue ◽  
Repair Capacity ◽  
Marine Origin ◽  
The Past ◽  
Advanced Therapies

The body´s self-repair capacity is limited, including injuries on articular cartilage zones. Over the past few decades, tissue engineering and regenerative medicine (TERM) have focused the studies on the development...

scholarly journals Design of a chitosan-based bio-scaffolding for regenerative medicine: compatibility analysis for cartilage regeneration

Biologija ◽  
2017 ◽  
Vol 63 (2) ◽  
Author(s):  
Seyed Ali (Behruz) Khaghani ◽  
Gunay Akbarova ◽  
Gulrukh Dilbazi
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Cartilage Repair ◽  
Cartilage Regeneration ◽  
Clinical Applications ◽  
Elastic Behaviour ◽  
Temperature Changes ◽  
Compatibility Analysis

Background. Evaluation of any material that is utilised for clinical applications is essential in order to ensure that it acquires physical, mechanical and biocompatible properties required for its proposed function. Understanding of the conditions that regulate the mechanical and physical characteristics of a material particularly biopolymers is crucial in the field of cell and tissue engineering. The aim of this work is to assemble some polymers and crosslink with each other using β-glycerophosphate to produce a scaffolding which is suitable for in vitro tissue regeneration.Materials and methods. The experimental procedures in this project involved the culturing of cells in different suspensions containing control, CSG hydrogel, fibronectin, and hydrogel with fibronectin. The aim of the conducted experiment was to find the cell viability and cytotoxicity analysis of CSG hydrogel, and to study how the cells interact with CSG hydrogel as a possible candidate for articular cartilage repair. Another aim of this work was to find out whether the cells can grow and survive in CSG hydrogel for a period of 24 hours. Results and conclusions. The results obtained from series of tests proved that CSG3 has the most optimum properties, as it presented the highest viscosity at 37°C, the highest stability during temperature changes, and an enhanced elastic behaviour at the physiological temperature.

scholarly journals Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage

2019 ◽  
Vol 37 (3) ◽  
pp. 11-12
Author(s):  
P. R. Van Weeren
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Paradigm Shift ◽  
Biological Effect ◽  
Platelet Rich Plasma ◽  
The Body ◽  
Biologically Active ◽  
Collagen Network ◽  
Gradual Process

Regenerative medicine aims at restoring or improving lost or affected functions of the body by stimulating the inherent healing capacity of tissues. The central paradigm of tissue engineering is that such repair is facilitated and enhanced using several approaches that may range from application of biologically active products (such as growth factor containing platelet rich plasma (PRP) or stem cells from a variety of sources) to the use of biofabricated implants. In all cases the aim is that in the end the body’s own healing capacity will result in the production of tissues that are identical to or at least functionally equivalent to the original tissues of which the function has been (partially) lost. In the case of the use of biofabricated implants, these are meant as temporary scaffolds that will stimulate the body’s own cells through a variety of cues but are destined to finally degrade and be replaced by newly made tissue. Ideally, this is a well-balanced gradual process in which there is a match between the disappearance (and loss of biological effect) of the engineered tissues and the formation (and increased biological effect) of the native tissues that replace the implant.There are many examples of successful applications of this theory, e.g. in the areas of bladder reconstruction (Londono & Badylak 2015). However, recently, it has become clear that this concept (and hence the paradigm) does not hold for articular cartilage because the collagen network, which is crucial for the biomechanical functions of articular cartilage, will, once damaged, not be reconstituted to any degree in mature individuals (Heinemeier et al. 2016). For this reason, a paradigm shift is necessary in the field of regenerative medicine of articular cartilage and attempts at tissue engineering in this field will have to be redirected. There are in principle two ways to achieve such a paradigm shift: either by recreating the tissue homeostatic and (epi)genetic environment as present in fetuses and young, growing, individuals in which remodeling of the collagen network is still possible, or by adopting Nature’s approach in the mature individual, i.e. by creating a life-long persisting, immutable structural component of articular cartilage. Both ways face considerable challenges before they can become reality.

The Effect of Total Meniscectomy versus Caudal Pole Hemimeniscectomy on the Stifle Joint of the Sheep

1999 ◽  
Vol 12 (02) ◽  
pp. 56-63 ◽  
Author(s):  
C. R. Bellenger ◽  
P. Ghosh ◽  
Y. Numata ◽  
C. Little ◽  
D. S. Simpson
Keyword(s):  
Tissue Culture ◽  
Articular Cartilage ◽  
Fibrous Tissue ◽  
Cartilage Degeneration ◽  
Medial Compartment ◽  
Proteoglycan Synthesis ◽  
Stifle Joint ◽  
Medial Meniscectomy ◽  
Tibial Condyle ◽  
Articular Cartilage Degeneration

SummaryTotal medial meniscectomy and caudal pole hemimeniscectomy were performed on the stifle joints of twelve sheep. The two forms of meniscectomy produced a comparable degree of postoperative lameness that resolved within two weeks of the operations. After six months the sheep were euthanatised and the stifle joints examined. Fibrous tissue that replaced the excised meniscus in the total meniscectomy group did not cover as much of the medial tibial condyle as the residual cranial pole and caudal fibrous tissue observed following hemimeniscectomy. The articular cartilage from different regions within the joints was examined for gross and histological evidence of degeneration. Analyses of the articular cartilage for water content, glycosaminoglycan composition and DNA content were performed. The proteoglycan synthesis and release from explanted articular cartilage samples in tissue culture were also measured. There were significant pathological changes in the medial compartment of all meniscectomised joints. The degree of articular cartilage degeneration that was observed following total meniscectomy and caudal pole meniscectomy was similar. Caudal pole hemimeniscectomy, involving transection of the meniscus, causes the same degree of degeneration of the stifle joint that occurs following total meniscectomy.The effect of total medial meniscectomy versus caudal pole hemimeniscectomy on the stifle joint of sheep was studied experimentally. Six months after the operations gross pathology, histopathology, cartilage biochemical analysis and the rate of proteoglycan synthesis in tissue culture were used to compare the articular cartilage harvested from the meniscectomised joints. Degeneration of the articular cartilage from the medial compartment of the joints was present in both of the groups. Caudal pole hemimeniscectomy induces a comparable degree of articular cartilage degeneration to total medial meniscectomy in the sheep stifle joint.

Tissue engineering in regenerative medicine

2015 ◽  
Vol 6 (5) ◽  
pp. 291-298
Author(s):  
Barbara Różalska ◽  
Bartłomiej Micota ◽  
Małgorzata Paszkiewicz ◽  
Beata Sadowska
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine

Graphene and Graphene-Based Materials in Biomedical Applications

2019 ◽  
Vol 26 (38) ◽  
pp. 6834-6850 ◽  
Author(s):  
Mohammad Omaish Ansari ◽  
Kalamegam Gauthaman ◽  
Abdurahman Essa ◽  
Sidi A. Bencherif ◽  
Adnan Memic
Keyword(s):  
Tissue Engineering ◽  
Thermal Properties ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Two Dimensional ◽  
Drug And Gene Delivery ◽  
Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

Sign in / Sign up

Export Citation Format

Share Document