Young maternal age and smoking during pregnancy as risk factors for gastroschisis

Teratology ◽  
1993 ◽  
Vol 47 (3) ◽  
pp. 225-228 ◽  
Author(s):  
James E. Haddow ◽  
Glenn E. Palomaki ◽  
Mary S. Holman
Keyword(s):  
Risk Factors ◽  
Maternal Age ◽  
Smoking During Pregnancy ◽  
Young Maternal Age

scholarly journals DATA LINKAGE FOR EVALUATING MATERNAL INFLUENCES ON INFANT MORTALITY AND MALTREATMENT IN CANADA

2018 ◽  
Vol 23 (suppl_1) ◽  
pp. e4-e4
Author(s):  
Jennifer Smith ◽  
Astrid Guttmann ◽  
Alexander Kopp ◽  
Michelle Shouldice ◽  
Katie Harron
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Child Maltreatment ◽  
Infant Mortality ◽  
Maternal Age ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Young Maternal Age

Abstract BACKGROUND A number of social risk factors are reported to increase infant mortality rates and child maltreatment. Public health programs attempt to mitigate risk factors and improve outcomes for infants. This study aimed to explore the association of exposure factors in mothers with infant mortality and maltreatment in Ontario. OBJECTIVES Objectives for this study included: 1. Describe prevalence of infant mortality and maltreatment in Ontario. 2. Explore how maternal risk factors influence infant mortality and maltreatment. DESIGN/METHODS This was a population-based study of 845, 567 infants born between April 1, 2005 and March 31, 2015 using administrative and healthcare databases available at the Institute of Clinical Evaluative Sciences (ICES). Maternal risk factors were selected based on public health home visiting referral criteria. These exposures included, maternal adversity (substance abuse, intimate partner violence, homelessness), newcomer status (new to Canada in past 3 years) and young maternal age (less than 22 years of age). The primary outcome measure was all-cause mortality of infants less than 12 months age. The secondary outcome measures were combined fatal and non-fatal child maltreatment outcomes and were defined using International Classification of Diseases for maltreatment diagnoses. Baseline characteristics and outcomes were described. The association between maternal risk factors and infant mortality and maltreatment was analysed using multivariable logistic modelling, including analysis by type of maternal risk factors and number of risk factors. RESULTS All-cause deaths were present in 0.14% and combined fatal and non-fatal maltreatment outcomes were present in 0.05% of the study population. Young maternal age increased the risk of all-cause mortality 2.4 times (n 171, OR 2.4, 95% CI 2.0–3.0) and maltreatment 6.3 times (n 292, OR 6.3, 95% CI 5.0–7.8). Mental health diagnosis increased the odds of maltreatment by 90% (n 209, OR 1.9, 95% CI 1.5–2.4). Adversity increased the odds of maltreatment by 63% (n 40, OR 1.63, 95% CI 1.0–2.6). The risk of maltreatment also increased as the number of risk factors increased with an OR of 3.5 (95% CI 2.9–4.4) with one risk factor, an OR of 8.2 (95% CI 5.9–11.4) with two risk factors, and an OR of 10.9 (95% CI 5.7 20.7) with three or more risk factors. Newcomer status was not associated with increased risk of maltreatment and mortality. Gestational age showed increasing ORs as prematurity increased. Material deprivation was included as a covariate and was associated with increased risk of maltreatment with increased level of deprivation. CONCLUSION Young maternal age carried the greatest risk of death and maltreatment in infants. There was also an increasing risk of infant mortality and maltreatment with increasing number of risk factors. These findings are important for ensuring public health interventions are targeting the most vulnerable populations with the aim of preventing maltreatment.

Risk Factors for Child Abuse: Methodologic Standards in Case-Control Studies

PEDIATRICS ◽  
1981 ◽  
Vol 68 (5) ◽  
pp. 684-690
Author(s):  
John M. Leventhal
Keyword(s):  
Risk Factors ◽  
Child Abuse ◽  
Risk Factor ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Maternal Age ◽  
Case Control ◽  
Control Group ◽  
Case Control Studies ◽  
Young Maternal Age

To determine whether the findings of case-control studies of risk factors for child abuse may have been biased because of inattention to scientific principles of research design, 22 case-control studies were reviewed investigating either of two risk factors: (1) prematurity or low birth weight of the abused child or (2) young maternal age of the mother of the abused child. Each study was examined to determine compliance with seven methodologic standards that would minimize bias or distortion of the results. No study satisfied all seven standards. Two standards, choice of a specific control group and adjustment for differences in clinical and demographic susceptibility factors, most often affected the results. Studies complying with both of these standards indicated that prematurity or low birth weight is not a risk factor for abuse and that young maternal age at the birth of the abused child is likely to be a risk factor. Few studies complied with the standard concerned with avoidance of detection bias; this failure may have a major effect on the direction of the results of certain studies. Previous case-control studies of child abuse have important methodologic flaws that can affect the validity of the results. The standards presented should be helpful in planning methodologically rigorous studies.

scholarly journals Gastroschisis: methods and early outcomes of surgical treatment

2021 ◽  
Author(s):  
Michał Tomasz Puliński ◽  
Wojciech Choiński ◽  
Zofia Kędzierska ◽  
Krzysztof Łoń
Keyword(s):  
Risk Factors ◽  
Surgical Treatment ◽  
Abdominal Wall ◽  
Maternal Age ◽  
Primary Closure ◽  
Abdominal Cavity ◽  
Length Of Hospital Stay ◽  
The Mean ◽  
First Time ◽  
Young Maternal Age

Introduction: Gastroschisis is a congenital anomaly in which loops of intestine are displaced outside the abdominal cavity through a defect in the abdominal wall. The incidence is steadily increasing. It is particularly attributed to young maternal age. The defect requires urgent surgical intervention after birth. Aim: The article aims to present the methods and early outcomes of surgical treatment of new-borns with gastroschisis in the context of pre- and postnatal examinations, and attempts to identify risk factors for the occurrence of the defect. Material and methods: The study used data derived from medical records of 18 patients of the Regional Specialist Children’s Hospital in Olsztyn. Prenatal, peri- and postoperative outcomes were analysed. The new-borns were classified with simple and complex gastroschisis. Results and discussion: The defect was diagnosed prenatally in 15 new-borns. In 16 cases, gestation was terminated by caesarean section. The mean maternal age at birth was 23 years; 14 woman were pregnant for the first time. All new-borns were operated on on day 1 of life. In 14 patients, primary closure of the abdominal wall was performed. The mean duration of mechanical ventilation was 13.31 days, of total parenteral nutrition – 29 day, to the first administration of enteral nutrition – 11.88 days and the mean length of hospital stay was 39.75 days, in the group of infants with simple gastroschisis. Conclusions: Gastroschisis is a severe anomaly causing an immediate threat to life. The optimal treatment procedure is the primary closure of the abdominal wall. The use of silastic sac enables the staged closure. Risk factors include young maternal age and primiparity.

Maternal age at birth and daughter’s fecundability

2021 ◽  
Author(s):  
Olga Basso ◽  
Sydney K Willis ◽  
Elizabeth E Hatch ◽  
Ellen M Mikkelsen ◽  
Kenneth J Rothman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Maternal Age ◽  
Limited Information ◽  
Loss To Follow Up ◽  
Older Mothers ◽  
Registration Number ◽  
The Usa ◽  
Competing Interest

Abstract STUDY QUESTION Do daughters of older mothers have lower fecundability? SUMMARY ANSWER In this cohort study of North American pregnancy planners, there was virtually no association between maternal age ≥35 years and daughters’ fecundability. WHAT IS KNOWN ALREADY Despite suggestive evidence that daughters of older mothers may have lower fertility, only three retrospective studies have examined the association between maternal age and daughter’s fecundability. STUDY DESIGN, SIZE, DURATION Prospective cohort study of 6689 pregnancy planners enrolled between March 2016 and January 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS Pregnancy Study Online (PRESTO) is an ongoing pre-conception cohort study of pregnancy planners (age, 21-45 years) from the USA and Canada. We estimated fecundability ratios (FR) for maternal age at the participant’s birth using multivariable proportional probabilities regression models. MAIN RESULTS AND THE ROLE OF CHANCE Daughters of mothers ≥30 years were less likely to have previous pregnancies (or pregnancy attempts) or risk factors for infertility, although they were more likely to report that their mother had experienced problems conceiving. The proportion of participants with prior unplanned pregnancies, a birth before age 21, ≥3 cycles of attempt at study entry or no follow-up was greater among daughters of mothers <25 years. Compared with maternal age 25–29 years, FRs (95% CI) for maternal age <20, 20–24, 30–34, and ≥35 were 0.72 (0.61, 0.84), 0.92 (0.85, 1.00), 1.08 (1.00, 1.17), and 1.00 (0.89, 1.12), respectively. LIMITATIONS, REASONS FOR CAUTION Although the examined covariates did not meaningfully affect the associations, we had limited information on the participants’ mother. Differences by maternal age in reproductive history, infertility risk factors and loss to follow-up suggest that selection bias may partly explain our results. WIDER IMPLICATIONS OF THE FINDINGS Our finding that maternal age 35 years or older was not associated with daughter’s fecundability is reassuring, considering the trend towards delayed childbirth. However, having been born to a young mother may be a marker of low fecundability among pregnancy planners. STUDY FUNDING/COMPETING INTEREST(S) PRESTO was funded by NICHD Grants (R21-HD072326 and R01-HD086742) and has received in-kind donations from Swiss Precision Diagnostics, FertilityFriend.com, Kindara.com, and Sandstone Diagnostics. Dr Wise is a fibroid consultant for AbbVie, Inc. TRIAL REGISTRATION NUMBER n/a

Impact of smoking and fetal gender on preterm delivery

2020 ◽  
pp. 1-6
Author(s):  
Veronika Günther ◽  
Ibrahim Alkatout ◽  
Alexandra Stein ◽  
Nicolai Maass ◽  
Alexander Strauss ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Preterm Delivery ◽  
Preterm Infants ◽  
Preterm Births ◽  
World Health ◽  
Smoking During Pregnancy ◽  
Fetal Gender ◽  
Extremely Preterm ◽  
Heavy Smokers

Abstract According to the World Health Organization, smoking is the most important risk factor for adverse pregnancy outcomes in industrialized nations. We aimed to establish how fetal gender and smoking interact with regard to perinatal outcomes, especially preterm delivery. Data from 220,339 singleton pregnancies, obtained from the German Perinatal Survey in Schleswig-Holstein and registered between 2004 and 2017 were analyzed in regard to smoking behavior, fetal gender, and preterm delivery. The rate of preterm births was directly proportional to the women’s consumption of nicotine. The rate of preterm deliveries was 6.8% among nonsmokers, and 13.2% in women who were very heavy smokers (≥22 cigarettes/day). Very heavy smoking (≥22 cigarettes/day) had a marked impact on extremely preterm births (<28 weeks of gestation) and very preterm births (28–31 weeks of gestation). Preterm births increased by 1.2% from heavy smokers to very heavy smokers; the differences between the other groups ranged between 0.1% and 0.4%. Fetal gender also had an impact on preterm birth: male infants were predominant in nearly all groups of women who delivered preterm infants. Smoking during pregnancy and male gender are both risk factors for preterm delivery. Fetal gender should be given greater attention as one of the several risk factors of preterm birth. Due to the high rate of morbidity among preterm infants and enormous costs for the healthcare system, women should be encouraged to cease or at least reduce smoking during pregnancy.

scholarly journals Some Risk Factors for Low Birthweight Infants at Manado Hospital

2018 ◽  
Vol 35 (3-4) ◽  
pp. 94-100
Author(s):  
S. M. Salendu W. ◽  
Sutomo Raharjo ◽  
Immanuel Mustadjab ◽  
Nan Warouw
Keyword(s):  
Risk Factors ◽  
Maternal Age ◽  
Intrauterine Growth Retardation ◽  
Maternal Education ◽  
Low Birthweight ◽  
Term Infants ◽  
Intrauterine Growth ◽  
Hypertension In Pregnancy ◽  
History Of ◽  
In Pregnancy

The risk factors of low birthweight infants were assessed in a retrospective study covering 3607 singleton livebirth infants at Manado Hospital from January until December 1993. The analysis confirmed that patterns of risk birthweight hypertension in pregnancy (P<0.01), maternal education (P<0.01), maternal age (P<0.05), and parity (P<0.01), marital status (P<0.01), history of abortion (P<0.05), and parity (P<0.01). Anemia in pregnancy was also associated with birthweight in low birth weight (P<0.05). Asymetric intrauterine growth retardation (Ponderal Index below 2.32) was found both in premature and term infants.

Prenatal and postnatal risk factors for infantile pneumonia in a representative birth cohort

2011 ◽  
Vol 140 (7) ◽  
pp. 1277-1285 ◽  
Author(s):  
C. H. CHEN ◽  
H. J. WEN ◽  
P. C. CHEN ◽  
S. J. LIN ◽  
T. L. CHIANG ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family Environment ◽  
Large Population ◽  
Multivariate Logistic Regression Analysis ◽  
Antibiotic Use ◽  
Population Based ◽  
Study Cohort ◽  
Mortality And Morbidity ◽  
Smoking During Pregnancy ◽  
Maternal Overweight

SUMMARYPneumonia is an important cause of mortality and morbidity in infants. However, information of risk factors for pneumonia in children aged <6 months is limited. This study aimed to evaluate the risk factors and their contribution to infantile pneumonia in a large population-based survey. Of 24 200 randomly sampled main caregivers invited, 21 248 (87·8%) participated in this study. A structured questionnaire was used to interview the main caregivers. Information regarding whether hospitalization was required, family environment, and medical history were obtained. The prevalence of pneumonia was 0·62% in our study cohort. Multivariate logistic regression analysis showed that preterm birth, congenital cardiopulmonary disease, antibiotic use during pregnancy, maternal overweight, daily prenatal exposure to environmental tobacco smoke, maternal smoking during pregnancy, and visible mould on walls at home are risk factors associated with infantile pneumonia. Further study is warranted to investigate the causality and mechanisms of these novel factors.

scholarly journals Association between Maternal Smoking during Pregnancy and Low Birthweight: Effects by Maternal Age

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146241 ◽  
Author(s):  
Wei Zheng ◽  
Kohta Suzuki ◽  
Taichiro Tanaka ◽  
Moriyasu Kohama ◽  
Zentaro Yamagata ◽  
...  
Keyword(s):  
Maternal Smoking ◽  
Maternal Age ◽  
Low Birthweight ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Paternal and maternal age at pregnancy and autism spectrum disorders in offspring

2016 ◽  
Vol 55 (6) ◽  
pp. 345 ◽  
Author(s):  
Luh Putu Rihayani Budi ◽  
Mei Neni Sitaresmi ◽  
I Gusti Ayu Trisna Windiani
Keyword(s):  
Autism Spectrum Disorders ◽  
Maternal Age ◽  
Multivariable Analysis ◽  
Autism Spectrum ◽  
Paternal Age ◽  
Control Group ◽  
Smoking During Pregnancy ◽  
Past Half Century ◽  
Spectrum Disorders ◽  
Paternal Smoking

Background The prevalence of autism spectrum disorders(ASDs) has increased 10 times over the past half century,while paternal and maternal age at pregnancy has alsoincreased. Studies looking for an association between paternalor maternal age at pregnancy and ASDs in offspring have notbeen conclusive.Objective To assess for possible associations between paternaland maternal age at pregnancy and ASDs in offspring.Methods This case-control study had 50 case and 100control subjects, each case was matched for age and genderto two controls. Case subjects were obtained by consecutivesampling of patients aged 18 months to 7 years who visited theDevelopmental Behavioral & Community Pediatrics OutpatientClinic and private growth and development centers from Januaryto April 2013, while control group were children of the sameage range and same gender who visited pediatric outpatientclinic at Sanglah Hospital mostly due to acute respiratory tractinfection, without ASDs as assessed by the DSM-IV-TR criteria.We interviewed parents to collect the following data: maternaland paternal age at pregnancy, child’s birth weight, historyof asphyxia, hospital admission during the neonatal period,pathological labor, maternal smoking during pregnancy, paternalsmoking, and gestational age. Data analysis was performed withChi-square and Fisher’s exact tests.Results Multivariable analysis showed that higher paternal ageat pregnancy was associated with ASDs in offspring (OR 6.3;95%CI 2.0 to 19.3; P 0.001). However, there was no significantassociation between maternal age during pregnancy and theincidence of ASDs. Asphyxia and paternal smoking were alsoassociated with higher incidence of ASDs in the offspring (OR10.3; 95%CI 1.9 to 56.5; P 0.007 and OR 3.2; 95%CI 1.5 to 6.9;P 0.003, respectively).Conclusion􀀃􀀳􀁄􀁗􀁈􀁕􀁑􀁄􀁏􀀃􀁄􀁊􀁈􀀃􀂕􀀗􀀓􀀃􀁜􀁈􀁄􀁕􀁖􀀃􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃􀁗􀁋􀁈􀀃􀁕􀁌􀁖􀁎􀀃􀁒􀁉􀀃􀀤􀀶'􀁖􀀃in offspring by 6.3 times. In addition, paternal smoking increased the risk of ASDs in offspring by 3.2 times and asphyxia increasedthe risk of ASDs in offspring by 10.3 times.

scholarly journals Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study

2002 ◽  
Vol 17 (6) ◽  
pp. 1649-1656 ◽  
Author(s):  
Elise de La Rochebrochard ◽  
Patrick Thonneau
Keyword(s):  
Risk Factors ◽  
Maternal Age ◽  
Paternal Age ◽  
European Study
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