Effects of 4-hydroperoxycyclophosphamide (4-OOH-CP) and 4-hydroperoxydechlorocyclophosphamide (4-OOH-deCICP) on the cell cycle of post implantation rat embryos

Teratology ◽  
1992 ◽  
Vol 45 (2) ◽  
pp. 163-173 ◽  
Author(s):  
Sally A. Little ◽  
Philip E. Mirkes
Keyword(s):  
Cell Cycle ◽  
Rat Embryos ◽  
Post Implantation

scholarly journals Altered Cell Cycle Gene Expression and Apoptosis in Post-Implantation Dog Parthenotes

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e41256 ◽  
Author(s):  
Jung Eun Park ◽  
Min Jung Kim ◽  
Seung Kwon Ha ◽  
So Gun Hong ◽  
Hyun Ju Oh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Cell Cycle Gene ◽  
Altered Cell ◽  
Post Implantation ◽  
Cell Cycle Gene Expression

scholarly journals Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos

2017 ◽  
Vol 4 (1) ◽  
pp. 31-35
Author(s):  
Makoto Usami ◽  
Mina Takamatsu ◽  
Shugo Kazama ◽  
Katsuyoshi Mitsunaga ◽  
Atsuko Miyajima ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Proteomic Analysis ◽  
Rat Embryos ◽  
Post Implantation

Serum exhaustion by repeated culture of post-implantation rat embryos: trophic and metabolic factors

1986 ◽  
Vol 14 (5) ◽  
pp. 981-982 ◽  
Author(s):  
ADRIAN M. BROOKE ◽  
MARGARET K. PRATTEN ◽  
FELIX BECK
Keyword(s):  
Metabolic Factors ◽  
Rat Embryos ◽  
Post Implantation

Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early post-implantation mouse embryos

Development ◽  
1980 ◽  
Vol 55 (1) ◽  
pp. 33-51
Author(s):  
R. E. Poelmann
Keyword(s):  
Cell Cycle ◽  
Cell Kinetics ◽  
Tritiated Thymidine ◽  
Primitive Streak ◽  
Cell Number ◽  
Mouse Embryos ◽  
Surface Ectoderm ◽  
Dividing Cells ◽  
Post Implantation ◽  
Embryonic Ectoderm

The shape of the embryonic ectoderm of early post-implantation mouse embryos changes greatly in the period of 6·2–7·3 days post coitum. The subcellular morphology of the embryonic ectoderm remains unchanged, except in the primitive-streak region. Cell kinetics differ between ectodermal regions. These differences may be related to the changes in the shape of the ectoderm. The increase in cell number in the lateral ectoderm (the prospective surface ectoderm) exceeds that in the frontal ectoderm (the future neurectoderm). This is not due to differences in the duration of the cell cycle. It can be explained, however, by the occurrence of different relative numbers of dividing and non-dividing cells. These numbers vary between the two regions. The percentage of non-dividing cells in the frontal ectoderm may reach 45, whereas in the lateral ectoderm this percentage is not higher than 15. Autoradiography in tritiated thymidine-treated embryos combined with the mitotic indices gave us all of the parameters necessary to present a model capable of clarifying the growth of the ectoderm during gastrulation, as well as the changes in the shape of the ectoderm.

Comparison of growth in vitro and in vivo of post-implantation rat embryos

Development ◽  
1976 ◽  
Vol 36 (1) ◽  
pp. 133-144
Author(s):  
D. A. T. New ◽  
P. T. Coppola ◽  
D. L. Cockroft
Keyword(s):  
Culture Methods ◽  
Rat Embryos ◽  
Somite Stage ◽  
Rates Of Growth ◽  
Post Implantation

Rat embryos explanted at early head-fold stage and grown in vitro by improved culture methods were compared with littermates in vivo. Very similar rates of growth and differentiation were obtained over a period of 48 h, while the embryos developed to around the 25-somite stage.

The effects of Streptomyces hyaluronidase on tissue organization and cell cycle time in rat embryos

Development ◽  
1986 ◽  
Vol 98 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Gillian M. Morriss-Kay ◽  
Fiona Tuckett ◽  
Michael Solursh
Keyword(s):  
Cell Cycle ◽  
Extracellular Matrix ◽  
Cycle Time ◽  
Cell Number ◽  
Considerable Reduction ◽  
Blue Staining ◽  
Neuroepithelial Cell ◽  
Cell Cycle Time ◽  
Rat Embryos ◽  
Tissue Organization

Day 9 rat embryos (late presomite stage with cranial neural plate or very early neural folds) were cultured for various periods of time from 6–48 h in medium containing 20 TRU ml−1Streptomyces hyaluronidase. Exposure to the enzyme resulted in considerable reduction of mesenchymal extracellular matrix. Access of the enzyme to the embryo was confirmed by alcian blue staining which indicated considerable reduction of extracellular and cell surface hyaluronate. Cranial neurulation was retarded, but not inhibited, and migration of both neural crest and primary mesenchyme cells occurred. In general, morphology was normal at 48 h. The major effect was on growth: embryos were smaller, with slightly reduced neuroepithelial cell number and greatly reduced mesenchymal cell number. Neuroepithelial cell cycle time was slightly prolonged, and that of the mesenchyme more than doubled. This differential effect on the growth rates of these two tissues reflects the normal distribution of hyaluronate, which is particularly abundant in the mesenchymal extracellular matrix.

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