Reversible effects of triamcinolone and lack of effects with aspirin or L-656,224 on external genitalia of male Sprague-Dawley rats exposed in utero

Teratology ◽  
1991 ◽  
Vol 44 (5) ◽  
pp. 507-520 ◽  
Author(s):  
L. David Wise ◽  
Christine M. Vetter ◽  
Charles A. Anderson ◽  
Joseph M. Antonello ◽  
Robert L. Clark
Keyword(s):  
External Genitalia ◽  
In Utero ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Oral (gavage), in utero and post-natal exposure of Sprague–Dawley rats to low doses of tributyltin chloride

2004 ◽  
Vol 42 (2) ◽  
pp. 221-235 ◽  
Author(s):  
H Tryphonas ◽  
G Cooke ◽  
D Caldwell ◽  
G Bondy ◽  
M Parenteau ◽  
...  
Keyword(s):  
In Utero ◽  
Low Doses ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Sprague Dawley Rats ◽  
Tributyltin Chloride

Experimental cryptorchidism enhances testicular susceptibility to dibutyl phthalate or acrylamide in Sprague-Dawley rats

2019 ◽  
Vol 38 (8) ◽  
pp. 899-913 ◽  
Author(s):  
NP de Souza ◽  
AP Ferragut Cardoso ◽  
LMM Gomide ◽  
TRR Lima ◽  
HA Miot ◽  
...  
Keyword(s):  
Germ Cell ◽  
Dibutyl Phthalate ◽  
Reproductive Tract ◽  
In Utero ◽  
Seminiferous Tubules ◽  
Postnatal Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Extended Exposure

Cryptorchidism (CPT), the most common male congenital abnormality, is variably associated with other male reproductive tract problems. We evaluated if cryptorchid rats develop enhanced testicular susceptibility to dibutyl phthalate (DBP) or acrylamide (AA) after extended exposure. Three studies with rats were performed: (1) in utero and postnatal exposure to DBP or AA; (2) establishment of CPT and orchiopexy; and (3) in utero and postnatal exposures to DBP or AA associated with CPT/orchiopexy. Seminiferous tubules were histologically scored according to the severity of lesions: (1) Rats exposed to DBP (score 1.5) or AA (score 1.1) presented mostly preserved spermatogenesis. Some seminiferous tubules showed vacuolated germinative epithelium, germ cell apoptosis, and a Sertoli cell-only (SCO) pattern. (2) CPT (score 3.3) resulted in decreased absolute testes weights, degenerated and SCO tubules, and spermatogenesis arrest that were reversed by orchiopexy (score 1.1). (3) Exposure to DBP or AA with CPT/orchiopexy led to atrophic testes, spermatogenesis arrest, germ cell exfoliation/multinucleation, and SCO tubules (both chemicals score 2.5). Exposure to chemicals such as DBP or AA prevented the recovery of cryptorchid testes by orchiopexy. The possible role of environmental contaminants should be considered when looking for factors that modulate human testicular disorders associated with CPT.

Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed in utero and postnatally to dibutyl phthalate or acrylamide

2019 ◽  
Vol 29 (7) ◽  
pp. 488-498 ◽  
Author(s):  
Nathália P. Souza ◽  
Lora L. Arnold ◽  
Karen L. Pennington ◽  
Merielen G. Nascimento e Pontes ◽  
Helio A. Miot ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Dibutyl Phthalate ◽  
In Utero ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

In utero exposure to the environmental androgen trenbolone masculinizes female Sprague–Dawley rats

2007 ◽  
Vol 174 (1-3) ◽  
pp. 31-41 ◽  
Author(s):  
A HOTCHKISS ◽  
J FURR ◽  
E MAKYNEN ◽  
G ANKLEY ◽  
L GRAYJR
Keyword(s):  
In Utero ◽  
In Utero Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague–Dawley rats: Dose–response, and biochemical and pharamacokinetic parameters

Toxicology ◽  
2005 ◽  
Vol 215 (1-2) ◽  
pp. 149-169 ◽  
Author(s):  
Deanna J. Luebker ◽  
Raymond G. York ◽  
Kristen J. Hansen ◽  
John A. Moore ◽  
John L. Butenhoff
Keyword(s):  
Neonatal Mortality ◽  
Dose Response ◽  
In Utero ◽  
In Utero Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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