Importance of genetic predisposition and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats

Teratology ◽  
1988 ◽  
Vol 37 (4) ◽  
pp. 365-374 ◽  
Author(s):  
Ulf J. Eriksson
Keyword(s):  
Genetic Predisposition ◽  
Congenital Malformations ◽  
Diabetic Rats ◽  
Maternal Environment

Diabetic environment and genetic predisposition as causes of congenital malformations in NOD mouse embryos

Diabetes ◽  
1991 ◽  
Vol 40 (10) ◽  
pp. 1245-1250 ◽  
Author(s):  
H. Otani ◽  
O. Tanaka ◽  
R. Tatewaki ◽  
H. Naora ◽  
T. Yoneyama
Keyword(s):  
Genetic Predisposition ◽  
Congenital Malformations ◽  
Mouse Embryos ◽  
Nod Mouse

Increased Incidence of Congenital Malformations in the Offspring of Diabetic Rats and Their Prevention by Maternal Insulin Therapy

Diabetes ◽  
1982 ◽  
Vol 31 (1) ◽  
pp. 1-6 ◽  
Author(s):  
U. Eriksson ◽  
E. Dahlstrom ◽  
K. S. Larsson ◽  
C. Hellerstrom
Keyword(s):  
Insulin Therapy ◽  
Congenital Malformations ◽  
Diabetic Rats

scholarly journals Manipulations in Maternal Environment Reverse Periodontitis in Genetically Predisposed Rats

2002 ◽  
Vol 9 (4) ◽  
pp. 931-932 ◽  
Author(s):  
Frans Sluyter ◽  
Torbjørn Breivik ◽  
Alexander Cools
Keyword(s):  
Rat Model ◽  
Genetic Predisposition ◽  
Maternal Environment ◽  
Adult Age ◽  
Genetically Determined

ABSTRACT The predisposition to develop periodontitis is partly genetically determined in humans as well as in animals. Here we demonstrate, however, that early manipulations in the maternal environment of an animal (rat) model of periodontitis can fully reverse the genetic predisposition to develop periodontitis at adult age.

Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin therapy

Diabetes ◽  
1982 ◽  
Vol 31 (1) ◽  
pp. 1-6 ◽  
Author(s):  
U. Eriksson ◽  
E. Dahlstrom ◽  
K. S. Larsson ◽  
C. Hellerstrom
Keyword(s):  
Insulin Therapy ◽  
Congenital Malformations ◽  
Diabetic Rats

Diabetic Environment and Genetic Predisposition as Causes of Congenital Malformations in NOD Mouse Embryos

Diabetes ◽  
1991 ◽  
Vol 40 (10) ◽  
pp. 1245-1250 ◽  
Author(s):  
H. Otani ◽  
O. Tanaka ◽  
R. Tatewaki ◽  
H. Naora ◽  
T. Yoneyama
Keyword(s):  
Genetic Predisposition ◽  
Congenital Malformations ◽  
Mouse Embryos ◽  
Nod Mouse

Sites of Insulin Action Using Ferritin Labeling

1971 ◽  
Vol 29 ◽  
pp. 540-541
Author(s):  
Burton B. Silver ◽  
Ronald S. Nelson
Keyword(s):  
Electron Microscopy ◽  
Binding Sites ◽  
Anterior Pituitary ◽  
Insulin Action ◽  
Diabetic Rats ◽  
Insulin Antibody ◽  
Fat Pad ◽  
Target Organs ◽  
Uranium Salts ◽  
Sugar Levels

Some investigators feel that insulin does not enter cells but exerts its influence in some manner on the cell surface. Ferritin labeling of insulin and insulin antibody was used to determine if binding sites of insulin to specific target organs could be seen with electron microscopy.Alloxanized rats were considered diabetic if blood sugar levels were in excess of 300 mg %. Test reagents included ferritin, ferritin labeled insulin, and ferritin labeled insulin antibody. Target organs examined were were diaphragm, kidney, gastrocnemius, fat pad, liver and anterior pituitary. Reagents were administered through the left common carotid. Survival time was at least one hour in test animals. Tissue incubation studies were also done in normal as well as diabetic rats. Specimens were fixed in gluteraldehyde and osmium followed by staining with lead and uranium salts. Some tissues were not stained.

A PPARψ agonist improved diabetic state via decreasing TNF-α without any change including obesity in genetically obese diabetic rats

2001 ◽  
Vol 120 (5) ◽  
pp. A674-A674 ◽  
Author(s):  
A FUNAKOSHI ◽  
M ICHIKAWA ◽  
Y SATO ◽  
S KANAI ◽  
M OHTA ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Diabetic State ◽  
Tnf Α ◽  
Obese Diabetic Rats

791: Endothelial Rehabilitation - The Impact of Chronic PDE5 Inhibitors on Erectile Function and Protein Alterations in Cavernous Tissue of Diabetic Rats

2007 ◽  
Vol 177 (4S) ◽  
pp. 264-265
Author(s):  
Ling De Young ◽  
KokBin Lim ◽  
Jeffery Carson ◽  
Trustin Domes ◽  
Mussa Al-Numi ◽  
...  
Keyword(s):  
Erectile Function ◽  
Diabetic Rats ◽  
Pde5 Inhibitors ◽  
Cavernous Tissue ◽  
Protein Alterations ◽  
The Impact
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