Sodium salicylate teratogenicity in vitro

Teratology ◽  
1982 ◽  
Vol 26 (2) ◽  
pp. 167-171 ◽  
Author(s):  
J. C. Greenaway ◽  
Thomas H. Shepard ◽  
Alan G. Fantel ◽  
Mont R. Juchau
Keyword(s):  
Sodium Salicylate ◽  
Teratogenicity In Vitro

Anaerobic Glycolysis in Normal Human Erythrocytes Incubated in Vitro with Sodium Salicylate

1975 ◽  
Vol 49 (5) ◽  
pp. 375-384
Author(s):  
N. Worathumrong ◽  
A. J. Grimes
Keyword(s):  
Sodium Salicylate ◽  
Lactate Production ◽  
Glucose Consumption ◽  
Human Erythrocytes ◽  
Anaerobic Glycolysis ◽  
Initial Stimulus ◽  
Sodium Efflux ◽  
Normal Human ◽  
Concentration Changes

1. Some effects of sodium salicylate upon anaerobic glycolysis have been studied in normal human erythrocytes incubated for up to 6 h at 37°C in autologous sera. 2. Both glucose consumption and lactate production were stimulated by concentrations of salicylate up to 60 mmol/l but at the highest concentration used (90 mmol/l) an initial stimulus was followed by inhibition of glycolysis. 3. Losses occurred of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP) and adenosine 5′-phosphate (AMP) at higher concentrations of salicylate and there was a concomitant increase of inorganic phosphate. 4. Other phosphate esters underwent concentration changes at higher concentrations of salicylate that reflected inadequate concentrations of ATP for glycolysis. 5. The rates of sodium efflux from, and potassium influx into, erythrocytes were unaffected by the presence of salicylate at concentrations sufficient to stimulate glycolysis.

scholarly journals The effects of salicylate on the activity of rat liver tyrosine–2-oxoglutarate aminotransferase in vitro and in vivo

1972 ◽  
Vol 126 (2) ◽  
pp. 347-350 ◽  
Author(s):  
A. A.-B. Badawy
Keyword(s):  
Rat Liver ◽  
Pyridoxal Phosphate ◽  
Actinomycin D ◽  
Sodium Salicylate ◽  
Intraperitoneal Administration ◽  
Tyrosine Aminotransferase ◽  
Major Effect ◽  
Endogenous Activity

1. Salicylate, in concentrations of 0.25mm and above, enhances the basal activity of tyrosine–2-oxoglutarate aminotransferase in homogenates of rat liver incubated in the absence of added pyridoxal 5′-phosphate (endogenous activity). The effect is decreased by increasing the concentration of the cofactor. 2. The intraperitoneal administration of sodium salicylate enhances the activity of rat liver tyrosine aminotransferase; the major effect during the first hour being on the enzyme in the absence of added pyridoxal phosphate. Actinomycin D prevents the induction of the enzyme by cortisol and tryptophan. Induction by pyridoxine or salicylate is 50% inhibited by actinomycin D. The effects of the injections of various combinations of cortisol, pyridoxine and salicylate were also studied in the absence or presence of actinomycin D. 3. It is suggested that salicylate induces rat liver tyrosine aminotransferase by displacing its protein-bound cofactor and that a cofactor-type induction of the hepatic enzyme occurs in pyridoxine-treated rats.

scholarly journals Glucocorticoid-induced phospholipase A2-inhibitory proteins mediate glucocorticoid teratogenicity in vitro.

1984 ◽  
Vol 81 (4) ◽  
pp. 1140-1143 ◽  
Author(s):  
C. Gupta ◽  
M. Katsumata ◽  
A. S. Goldman ◽  
R. Herold ◽  
R. Piddington
Keyword(s):  
Phospholipase A2 ◽  
Inhibitory Proteins ◽  
Teratogenicity In Vitro

DIFFERENTIAL EFFECTS OF ORAL ADMINISTRATIONS OF ACETYL SALICYLIC ACID, INDOMETHACIN AND SODIUM SALICYLATE TO HUMAN SUBJECTS ON THE FORMATION OF 12-HYDROXYEICOSATETRAENOIC BY PLATELETS

1987 ◽  
Author(s):  
E Tremoli ◽  
D Caruso ◽  
P Maderna ◽  
G Galli ◽  
R Paoletti
Keyword(s):  
Sodium Salicylate ◽  
Platelet Rich Plasma ◽  
Human Subjects ◽  
Normal Subjects ◽  
Inhibitory Effect ◽  
Washed Platelet ◽  
Single Oral Administration ◽  
Selective Ion Monitoring ◽  
Platelet Formation

The effects of a single oral administration of acetylsalicylic acid (ASA, 500 mg), indomethacin (Indo, 50 mg) and sodium salicylate (SA, 400 mg) to healthy volunteers on platelet formation of 12-hydroxyeicosatetraenoic acid (12-HETE) were evaluated. Blood was collected before, 2, 6 and 24 hours after drug administrations. Platelet rich plasma (PRP) samples were stimulated with 20 μg/ml collagen and 12-HETE levels were determined by selective ion monitoring. The effects of ASA on the same parameter were also evaluated in vitro in PRP and in washed platelet (WP) samples in the absence and in the presence of platelet poor plasma (PPP, 25-100%) or bovine serum albumin (BSA, 10-40 mg/ml). In subjects who ingested ASA, the formation of 12-HETE in PRP stimulated with collagen was significantly inhibited 2 and 6 hours after the drug administration. At 24 h 12-HETE synthesis tended to return toward basal values. In contrast the administration of a single dose of Indo or of SA did not significantly affect 12-HETE synthesis by stimulated PRP. ASA (3 mM) added in vitro inhibited 12-HETE formation in PRP but not in WP. In addition ASA inhibited 12-HETE synthesis in washed platelets resuspended either in PPP (25-100 %) or in BSA (10-40 mg/ml). It is concluded ASA, but not Indo or SA, orally administered to normal subjects inhibits 12-HETE synthesis in collagen stimulated PRP. The results obtained in vitro suggest that albumin and/or some albumin component may be responsible for the inhibitory effect of ASA on platelet 12-HETE syntesis.

scholarly journals Short communication: Sodium salicylate negatively affects rumen fermentation in vitro and in situ

2017 ◽  
Vol 100 (3) ◽  
pp. 1935-1939 ◽  
Author(s):  
A.J. Carpenter ◽  
C.F. Vargas Rodriguez ◽  
J.A.B. Jantz ◽  
B.J. Bradford
Keyword(s):  
Short Communication ◽  
Sodium Salicylate ◽  
Rumen Fermentation

Teratogenicity in vitro of 2-acetylaminofluorene: Role of biotransformation in the rat

Teratology ◽  
1983 ◽  
Vol 27 (1) ◽  
pp. 19-28 ◽  
Author(s):  
E. Faustman-Watts ◽  
J. C. Greenaway ◽  
M. J. Namkung ◽  
A. G. Fantel ◽  
M. R. Juchau
Keyword(s):  
Teratogenicity In Vitro

Effects of leukocytic pyrogen and sodium salicylate on hypothalamic thermosensitive neurons in vitro

1984 ◽  
Vol 49 (3) ◽  
pp. 313-318 ◽  
Author(s):  
T. Hori ◽  
T. Nakashima ◽  
T. Kiyohara ◽  
M. Shibata
Keyword(s):  
Sodium Salicylate ◽  
Leukocytic Pyrogen
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