Congenital malformation syndromes and elevation of amniotic fluid α1-fetoprotein

Teratology ◽  
1981 ◽  
Vol 24 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Uta Burck ◽  
Karsten R. Held ◽  
Hans-J. Kitschke ◽  
Martin Carstensen
Keyword(s):  
Amniotic Fluid ◽  
Congenital Malformation ◽  
Malformation Syndromes

THE CARPALS IN CONGENITAL MALFORMATION SYNDROMES

1971 ◽  
Vol 112 (3) ◽  
pp. 443-459 ◽  
Author(s):  
ANDREW K. POZNANSKI ◽  
JOHN F. HOLT
Keyword(s):  
Congenital Malformation ◽  
Malformation Syndromes

scholarly journals Dysharmonic maturation of the hand in the congenital malformation syndromes

1971 ◽  
Vol 35 (3) ◽  
pp. 417-432 ◽  
Author(s):  
Andrew K. Poznanski ◽  
Stanley M. Garn ◽  
Lawrence R. Kuhns ◽  
Sam T. Sandusky
Keyword(s):  
Congenital Malformation ◽  
Malformation Syndromes

scholarly journals Congenital malformation syndromes with overlapping features

2017 ◽  
Vol 10 ◽  
pp. 79-80
Author(s):  
Chris Gammarano ◽  
Devon Laughlin ◽  
Van Truong ◽  
Hal Hawkins
Keyword(s):  
Congenital Malformation ◽  
Malformation Syndromes

Engineering tissue for the fetus: stem cells and matrix signalling

2014 ◽  
Vol 42 (3) ◽  
pp. 631-635 ◽  
Author(s):  
Paolo De Coppi
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Congenital Malformation ◽  
Congenital Malformations ◽  
Adult Stem Cells ◽  
Neonatal Period ◽  
Amniotic Fluid Stem Cells ◽  
The Future ◽  
Causes Of Disease ◽  
Functional Replacement

Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis, before birth, to be able to intervene during the gestation or in the neonatal period. Human AFSCs (amniotic fluid stem cells), which have characteristics intermediate between those of embryonic and adult stem cells, have been isolated. c-Kit+Lin− cells derived from amniotic fluid display a multilineage haemopoietic potential and they can be easily reprogrammed to a pluripotent status. Although, in the future, we hope to use cells derived from the amniotic fluid, we and others have proved recently that simple organs such as the trachea can be engineered using adult progenitors utilizing decellularized cadaveric matrices. A similar approach could be used in the future for more complex organs such as the muscles, intestines or lungs.

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