Graphic reconstructions of craniofacial structures during secondary palate development in rats

Teratology ◽  
1976 ◽  
Vol 14 (3) ◽  
pp. 291-313 ◽  
Author(s):  
Virginia M. Diewert
Keyword(s):  
Palate Development ◽  
Secondary Palate

Autoradiographic study of macromolecular synthesis in the fusion epithelium of the developing rat primary palate in vitro

Development ◽  
1979 ◽  
Vol 50 (1) ◽  
pp. 145-154
Author(s):  
Alvaro A. Figueroa ◽  
Robert M. Pratt
Keyword(s):  
Autoradiographic Study ◽  
Whole Embryo Culture ◽  
Glycoprotein Synthesis ◽  
Palate Development ◽  
Molecular Events ◽  
Secondary Palate ◽  
Primary Palate ◽  
Epithelial Fusion ◽  
Developing Rat

The facial processes involved in primary palate formation undergo epithelial fusion in a manner morphologically analogous to that observed during secondary palate formation. We have used whole embryo culture to analyze the synthesis of macromolecules (DNA, protein, glycoprotein) in the primary palate, based on the incorporation of various labeled precursors. The results of this study demonstrate that changes in the synthesis of macromolecules occur during the fusion of the facial processes, which resemble those previously reported to occur during secondary palate development. These changes include cessation of DNA synthesis in cells in a restricted zone of the epithelium, concomitant with maintenance of glycoprotein synthesis. These findings indicate that the molecular events underlying the development of the primary and secondary palate may be similar.

Secondary Palate Development in the Dog (Canis lupus familiaris)

2020 ◽  
pp. 105566562094377
Author(s):  
Katharina Freiberger ◽  
Shelby Hemker ◽  
Ryan McAnally ◽  
Rachel King ◽  
Vicki N. Meyers-Wallen ◽  
...  
Keyword(s):  
Large Animal Model ◽  
Large Animal ◽  
Canis Lupus Familiaris ◽  
Protein Markers ◽  
Serum Progesterone ◽  
Palate Development ◽  
Secondary Palate ◽  
Intermediate Time ◽  
Palate Repair ◽  
Isolated Cleft Palate

Objective: To investigate the gestational timing of morphologic events in normal canine secondary palate development as a baseline for studies in dog models of isolated cleft palate (CP). Methods: Beagle and beagle/cocker spaniel-hybrid fetal dogs were obtained by cesarean-section on various days of gestation, timed from the initial rise of serum progesterone concentration. Morphology of fetal heads was determined by examining serial coronal sections. Results: On gestational day 35 (d35), the palatal shelves pointed ventrally alongside the tongue. On d36, palatal shelves were elongated and elevated to a horizontal position above the tongue but were not touching. On d37, palatine shelves and vomer were touching, but the medial epithelial seam (MES) between the apposed shelves remained. Immunostaining with epithelial protein markers showed that the MES gradually dissolved and was replaced by mesenchyme during d37-d44, and palate fusion was complete by d44. Examination of remnant MES suggested that fusion of palatal shelves began in mid-palate and moved rostrally and caudally. Conclusion: Palate development occurs in dogs in the steps described in humans and mice, but palate closure occurs at an intermediate time in gestation. These normative data will form the basis of future studies to determine pathophysiologic mechanisms in dog models of CP. Added clinical significance is the enhancement of dogs as a large animal model to test new approaches for palate repair, with the obvious advantage of achieving full maturity within 2 years rather than 2 decades.

Extracellular Matrix in Secondary Palate Development

2019 ◽  
Vol 303 (6) ◽  
pp. 1543-1556 ◽  
Author(s):  
Shaun M. Logan ◽  
L. Bruno Ruest ◽  
M. Douglas Benson ◽  
Kathy K. H. Svoboda
Keyword(s):  
Extracellular Matrix ◽  
Palate Development ◽  
Secondary Palate

The Course of the Palatine Arteries During Secondary Palate Development in the Rat

1973 ◽  
Vol 52 (6) ◽  
pp. 1273-1280 ◽  
Author(s):  
Virginia M. Diewert
Keyword(s):  
Blood Supply ◽  
Palate Development ◽  
Rat Fetuses ◽  
Secondary Palate ◽  
Primary Palate

The course of the palatine arteries was studied in 96 rat fetuses. The descending palatine arteries were a major blood supply to the incisive area of the primary palate. When shelves were elevated, the arteries became positioned more medially and changed from a semicircular to a V-shaped form in the pre-maxilla.

scholarly journals Molecular and Cellular Mechanisms of Palate Development

2017 ◽  
Vol 96 (11) ◽  
pp. 1184-1191 ◽  
Author(s):  
C. Li ◽  
Y. Lan ◽  
R. Jiang
Keyword(s):  
Growth Factor ◽  
Regulatory Networks ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cellular Mechanisms ◽  
Palate Development ◽  
Palatal Shelf ◽  
Cellular Processes ◽  
Morphogenetic Protein ◽  
Secondary Palate

Development of the mammalian secondary palate involves highly dynamic morphogenetic processes, including outgrowth of palatal shelves from the oral side of the embryonic maxillary prominences, elevation of the initially vertically oriented palatal shelves to the horizontal position above the embryonic tongue, and subsequently adhesion and fusion of the paired palatal shelves at the midline to separate the oral cavity from the nasal cavity. Perturbation of any of these processes could cause cleft palate, a common birth defect that significantly affects patients’ quality of life even after surgical treatment. In addition to identifying a large number of genes required for palate development, recent studies have begun to unravel the extensive cross-regulation of multiple signaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast growth factor, transforming growth factor β, and Wnt signaling, and multiple transcription factors during palatal shelf growth and patterning. Multiple studies also provide new insights into the gene regulatory networks and/or dynamic cellular processes underlying palatal shelf elevation, adhesion, and fusion. Here we summarize major recent advances and integrate the genes and molecular pathways with the cellular and morphogenetic processes of palatal shelf growth, patterning, elevation, adhesion, and fusion.

scholarly journals Foxf2 is required for secondary palate development and Tgfβ signaling in palatal shelf mesenchyme

2016 ◽  
Vol 415 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Ali M. Nik ◽  
Jeanette A. Johansson ◽  
Mozhgan Ghiami ◽  
Azadeh Reyahi ◽  
Peter Carlsson
Keyword(s):  
Tgfβ Signaling ◽  
Palate Development ◽  
Palatal Shelf ◽  
Secondary Palate
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