Median facial cleft syndrome in half-sisters. Dilemmas in genetic counseling

Josef Warkany; Mary K. Bofinger; Corning Benton

doi:10.1002/tera.1420080307

Median facial cleft syndrome in half-sisters. Dilemmas in genetic counseling

Teratology ◽

10.1002/tera.1420080307 ◽

1973 ◽

Vol 8 (3) ◽

pp. 273-285 ◽

Cited By ~ 36

Author(s):

Josef Warkany ◽

Mary K. Bofinger ◽

Corning Benton

Keyword(s):

Genetic Counseling ◽

Facial Cleft ◽

Median Facial Cleft Syndrome

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Median Cleft of the Lip: Its Significance and Surgical Repair

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_1993_030_0094_mcotli_2.3.co_2 ◽

1993 ◽

Vol 30 (1) ◽

pp. 94-96 ◽

Cited By ~ 14

Author(s):

James Apesos ◽

Gregg M. Anigian

Keyword(s):

Surgical Technique ◽

Cleft Lip ◽

Surgical Repair ◽

Surgical Reconstruction ◽

Upper Lip ◽

Facial Cleft ◽

Median Cleft ◽

Median Facial Cleft Syndrome ◽

Associated Abnormalities

Median cleft lip is a midline vertical cleft through the upper lip in the absence of a prolabial remnant. This may occur as a sporadic event or be part of an inherited sequence of anomalies. A failure of formation or fusion of the medial nasal prominences derived from the frontonasal prominence is ultimately responsible for this aberration. Two categories of dysplasia are associated: (1) frontonasal deformity associated with hypotelorism and (2) median facial cleft syndrome associated with hypertelorism. A patient presents with median cleft lip, mild bifid nose, and hypertelorism. Following surgical reconstruction, a good result is achieved. The embryology, implications for associated abnormalities, and surgical technique for treating these cases are discussed.

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Median facial cleft syndrome: A case report

IP Indian Journal of Anatomy and Surgery of Head Neck and Brain ◽

10.18231/j.ijashnb.2021.014 ◽

2021 ◽

Vol 7 (2) ◽

pp. 61-63

Author(s):

Kaushik Bhattacharya ◽

Aditya Shikar Bhattacharya ◽

Neela Bhattacharya

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Upper Lip ◽

Live Births ◽

Facial Cleft ◽

The Face ◽

Median Cleft ◽

Median Facial Cleft Syndrome ◽

Congenital Cleft ◽

Type 3

Congenital Cleft Lip and Palate is a common birth defect with an incidence of 1 in 600 to 800 live births. This defect usually affects either the left, right or in some cases both sides of the lip and is called a Tessier Type 3 cleft. Clefting of the face in the midline is exceedingly rare and such a case of a Median Facial Cleft Syndrome is being reported which occurs in nearly 1 in 1,000,000 live births. This was first described by Bechard in 1823 and can be sporadic or part of an inherited syndrome. The child had a median cleft of the upper lip, nose, and palate of a severe, complete variety, with absent philtrum of the upper lip, premaxilla, columella, nasal septum and vomer.

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