Investigation of the genotoxic effect in bone marrow of Swiss albino mice exposed long-term to pyrimethamine

2002 ◽  
Vol 22 (6) ◽  
pp. 393-402 ◽  
Author(s):  
B. Tunca ◽  
U. Egeli ◽  
N. Aydemir ◽  
G. Cecener ◽  
R. Bilaloglu
Keyword(s):  
Bone Marrow ◽  
Genotoxic Effect ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Sahdeo Prasad ◽  
Smita Srivastava ◽  
Madhulika Singh ◽  
Yogeshwer Shukla
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Positive Control ◽  
Vehicle Group ◽  
Control Group ◽  
Mouse Bone Marrow ◽  
Human Beings ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Marrow Cells

Glyphosate (N-(phosphonomethyl) glycine,C3H8NO5P), a herbicide, used to control unwanted annual and perennial plants all over the world. Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings. Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice. A single dose of glyphosate was given intraperitoneally (i.p) to the animals at a concentration of 25 and 50 mg/kg b.wt. Animals of positive control group were injectedi.p. benzo(a)pyrene (100 mg/kg b.wt., once only), whereas, animals of control (vehicle) group were injectedi.p. dimethyl sulfoxide (0.2mL). Animals from all the groups were sacrificed at sampling times of 24, 48, and 72 hours and their bone marrow was analyzed for cytogenetic and chromosomal damage. Glyphosate treatment significantly increases CAs and MN induction at both treatments and time compared with the vehicle control (P<.05). The cytotoxic effects of glyphosate were also evident, as observed by significant decrease in mitotic index (MI). The present results indicate that glyphosate is clastogenic and cytotoxic to mouse bone marrow.

scholarly journals THE EFFECT OF CELLS TRANSFERRED INTO THE MOUSE BLASTOCYST ON SUBSEQUENT DEVELOPMENT

1974 ◽  
Vol 140 (4) ◽  
pp. 1049-1056 ◽  
Author(s):  
R. L. Brinster
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Subsequent Development ◽  
Blastocyst Stage ◽  
Skin Grafts ◽  
Mouse Blastocyst ◽  
Swiss Albino Mice ◽  
Foster Mothers ◽  
Teratocarcinoma Cells ◽  
Albino Mice

Bone marrow cells from CBA T6T6 mice and testicular teratocarcinoma cells from 129 SvSl mice were transferred into blastocysts from random-bred Swiss albino mice. The blastocysts were allowed to develop in foster mothers and the adults resulting from these blastocysts were studied for evidence of an effect of the transferred cells. A total of 137 adults resulted from the experiments, and one of the mice that had received teratocarcinoma cells in the blastocyst stage showed several thin stripes of agouti hair. All the adult animals received grafts of skin from animals identical to those supplying the cells. In all cases the animals that resulted from blastocysts into which cells had been transferred maintained skin grafts for a significantly longer period than controls. In a number of cases the graft developed agouti hair and in two cases the graft was maintained for approximately 2 mo. These experiments indicate that the transferred cells were able to establish small colonies in the embryos and that some of these cells persisted into the adult.

Effect of nerolidol on cyclophosphamide-induced bone marrow and hematologic toxicity in Swiss albino mice

2020 ◽  
Vol 82 ◽  
pp. 24-32 ◽  
Author(s):  
Ashif Iqubal ◽  
Mansoor Ali Syed ◽  
Mohammad Mahfuzul Haque ◽  
Abul Kalam Najmi ◽  
Javed Ali ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hematologic Toxicity ◽  
Swiss Albino Mice ◽  
Albino Mice
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