Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration

Synapse ◽  
1995 ◽  
Vol 21 (4) ◽  
pp. 312-318 ◽  
Author(s):  
David W. Self ◽  
Amanda W. McClenahan ◽  
Dana Beitner-Johnson ◽  
Rose Z. Terwilliger ◽  
Eric J. Nestler
Keyword(s):  
Mesolimbic Dopamine ◽  
Self Administration ◽  
Dopamine System ◽  
Mesolimbic Dopamine System

The involvement of mesolimbic dopamine system in cotinine self-administration in rats

2021 ◽  
pp. 113596
Author(s):  
Xiaoying Tan ◽  
Cynthia M. Ingraham ◽  
William J. McBride ◽  
Zheng-Ming Ding
Keyword(s):  
Mesolimbic Dopamine ◽  
Self Administration ◽  
Dopamine System ◽  
Mesolimbic Dopamine System

scholarly journals The mesolimbic dopamine signatures of relapse to alcohol-seeking

2020 ◽  
Author(s):  
Yu Liu ◽  
Philip Jean-Richard-dit-Bressel ◽  
Joanna Oi-Yue Yau ◽  
Alexandra Willing ◽  
Asheeta A. Prasad ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Activity Patterns ◽  
Mesolimbic Dopamine ◽  
Self Administration ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Ventral Tegmental ◽  
Alcohol Seeking

AbstractThe mesolimbic dopamine system comprises distinct compartments supporting different functions in learning and motivation. Less well understood is how complex addiction-related behaviors emerge from activity patterns across these compartments. Here we show how different forms of relapse to alcohol-seeking are assembled from activity across the ventral tegmental area and the nucleus accumbens. Using gCaMP and dLight fibre photometry, we show that self-administration and two forms of relapse (renewal/context-induced reinstatement and reacquisition) are associated with recruitment across the mesolimbic dopamine system. Using a variety of interventions, we show that this activity is causal to both forms of relapse. Finally, we use dissimilarity matrices to identify mesolimbic dopamine signatures of self-administration, extinction, and relapse. We show that signatures of relapse can be identified from heterogeneous activity profiles across the mesolimbic dopamine system and that these signatures differ for different forms of relapse.

scholarly journals The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

2010 ◽  
Vol 31 (2) ◽  
pp. 336-348 ◽  
Author(s):  
Rodrigo A. España ◽  
Erik B. Oleson ◽  
Jason L. Locke ◽  
Bethany R. Brookshire ◽  
David C. S. Roberts ◽  
...  
Keyword(s):  
Mesolimbic Dopamine ◽  
Self Administration ◽  
Dopamine System ◽  
Mesolimbic Dopamine System

1-Phenylcyclohexan-1-amine hydrochloride (PCA HCl) alters mesolimbic dopamine system accompanied by neuroplastic changes: A neuropsychopharmacological evaluation in rodents

2021 ◽  
Vol 144 ◽  
pp. 104962
Author(s):  
Arvie Abiero ◽  
Raly James Perez Custodio ◽  
Chrislean Jun Botanas ◽  
Darlene Mae Ortiz ◽  
Leandro Val Sayson ◽  
...  
Keyword(s):  
Amine Hydrochloride ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System

Encoding of Action Sequences by the Mesolimbic Dopamine System

2021 ◽  
Vol 89 (9) ◽  
pp. S121
Author(s):  
Eric Zimmerman ◽  
Zoe LaPalombara ◽  
Susanne Ahmari
Keyword(s):  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Action Sequences

Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

2019 ◽  
Vol 356 ◽  
pp. 156-169 ◽  
Author(s):  
Katayoun Sedaghat ◽  
Zahra Yousefian ◽  
Abbas Ali Vafaei ◽  
Ali Rashidy-Pour ◽  
Houman Parsaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System
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