Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): Evidence from using CuZn-superoxide dismutase transgenic mice

Synapse ◽  
1995 ◽  
Vol 21 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Jean Lud Cadet ◽  
Bruce Ladenheim ◽  
Hiroshi Hirata ◽  
Richard B. Rothman ◽  
Syed Ali ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Transgenic Mice ◽  
Superoxide Radicals ◽  
Biochemical Effects ◽  
Cuzn Superoxide Dismutase

No effect of superoxide dismutase on spontaneous development of diabetes in db/db mice

1988 ◽  
Vol 117 (1) ◽  
pp. 99-102
Author(s):  
Ove Berglund ◽  
Kjell Grankvist ◽  
Carina Albiin ◽  
Stefan L. Marklund
Keyword(s):  
Superoxide Dismutase ◽  
B Cells ◽  
Superoxide Radical ◽  
Superoxide Radicals ◽  
Cuzn Superoxide Dismutase

Abstract. B-cells have previously been shown to be very susceptible to damage induced by superoxide radicals, and protection against such damage has been achieved both in vitro and in vivo with superoxide dismutase. During maturation, db/db mice develop diabetes and accumulation of potentially superoxide radical-producing leucocytes can be demonstrated in the islets during the process. To test for the possibility that superoxide radical-induced damage contributes to the development of diabetes, db/db mice were given daily ip injections of 200 mg/kg polyethylene glycolsubstituted CuZn superoxide dismutase. No effect of the treatment could be demonstrated.

Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-Superoxide dismutase

1991 ◽  
Vol 29 (5) ◽  
pp. 482-486 ◽  
Author(s):  
P. H. Chan ◽  
G. Y. Yang ◽  
S. F. Chen ◽  
E. Carlson ◽  
C. J. Epstein
Keyword(s):  
Superoxide Dismutase ◽  
Transgenic Mice ◽  
Brain Edema ◽  
Cuzn Superoxide Dismutase

scholarly journals Amelioration of Vasospasm After Subarachnoid Hemorrhage in Transgenic Mice Overexpressing CuZn–Superoxide Dismutase

Stroke ◽  
1999 ◽  
Vol 30 (4) ◽  
pp. 867-872 ◽  
Author(s):  
Hideyuki Kamii ◽  
Ichiro Kato ◽  
Hiroyuki Kinouchi ◽  
Pak H. Chan ◽  
Charles J. Epstein ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Subarachnoid Hemorrhage ◽  
Transgenic Mice ◽  
Cuzn Superoxide Dismutase

Autoradiographic evidence for methamphetamine-induced striatal dopaminergic loss in mouse brain: attenuation in CuZn-superoxide dismutase transgenic mice

1996 ◽  
Vol 714 (1-2) ◽  
pp. 95-103 ◽  
Author(s):  
Hiroshi Hirata ◽  
Bruce Ladenheim ◽  
Elaine Carlson ◽  
Charles Epstein ◽  
Jean Lud Cadet
Keyword(s):  
Superoxide Dismutase ◽  
Transgenic Mice ◽  
Mouse Brain ◽  
Cuzn Superoxide Dismutase

CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations

2001 ◽  
Vol 102 (4) ◽  
pp. 293-305 ◽  
Author(s):  
Dick Jaarsma ◽  
Francesca Rognoni ◽  
Wim van Duijn ◽  
Hein W. Verspaget ◽  
Elize D. Haasdijk ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Superoxide Dismutase ◽  
Transgenic Mice ◽  
Cuzn Superoxide Dismutase ◽  
Lateral Sclerosis
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