Effects of chronic ethanol ingestion on long-term potentiation remain even after a prolonged recovery from ethanol exposure

Synapse ◽  
1994 ◽  
Vol 17 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Margaret F. Tremwel ◽  
Bruce E. Hunter
Keyword(s):  
Long Term Potentiation ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Ethanol Ingestion ◽  
Term Potentiation ◽  
Prolonged Recovery

Repeated Ethanol Exposure and Withdrawal Impairs Human Fear Conditioning and Depresses Long-Term Potentiation in Rat Amygdala and Hippocampus

2005 ◽  
Vol 58 (5) ◽  
pp. 392-400 ◽  
Author(s):  
David N. Stephens ◽  
Tamzin L. Ripley ◽  
Gilyana Borlikova ◽  
Manja Schubert ◽  
Doris Albrecht ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Ethanol Exposure ◽  
Term Potentiation

Long-Term Potentiation in the Rat Hippocampus Is Reversibly Depressed by Chronic Intermittent Ethanol Exposure

2002 ◽  
Vol 87 (5) ◽  
pp. 2385-2397 ◽  
Author(s):  
M. Roberto ◽  
T. E. Nelson ◽  
C. L. Ur ◽  
D. L. Gruol
Keyword(s):  
Synaptic Plasticity ◽  
Alcohol Use ◽  
Alcohol Exposure ◽  
Long Term Potentiation ◽  
Ethanol Exposure ◽  
Chronic Alcohol ◽  
Chronic Intermittent Ethanol ◽  
Term Potentiation ◽  
Neuroadaptive Changes

Alcohol exposure induces multiple neuroadaptive changes in the CNS that can have serious long-term consequences on CNS function including cognitive effects and attenuation of learning and memory. The cellular mechanisms underlying the CNS effects of alcohol have yet to be fully elucidated and are likely to depend on the pattern and dose of alcohol exposure. Using electrophysiological recordings from hippocampal slices obtained from control and chronic alcohol-treated rats, we have investigated the effects of a binge pattern of alcohol abuse on synaptic plasticity in the CNS. The alcohol-treated animals were exposed to ethanol vapor for 12–14 days using an intermittent exposure paradigm (14 h ethanol exposure/10 h ethanol withdrawal daily; blood alcohol levels ∼180 mg/dl), a paradigm that models human binge alcohol use. Induction of long-term potentiation (LTP) in the CA1 region of the hippocampus by tetanic stimulation of Schaffer collaterals was completely blocked in slices from the chronic alcohol-treated animals. LTP remained blocked 1 day after withdrawal of animals from alcohol, indicating that the neuroadaptive changes produced by alcohol were not readily reversible. Partial recovery was observed after withdrawal from alcohol for 5 days. Other measures of synaptic plasticity including posttetanic potentiation and paired-pulse facilitation were also altered by the intermittent alcohol treatment paradigm. The results suggest that alterations in synaptic plasticity induced by chronic intermittent ethanol consumption play an important role in the effects of binge alcohol use on learning and memory function.

Prenatal ethanol exposure has sex-specific effects on hippocampal long-term potentiation

Hippocampus ◽  
2013 ◽  
Vol 24 (1) ◽  
pp. 54-64 ◽  
Author(s):  
H.M. Sickmann ◽  
A.R. Patten ◽  
K. Morch ◽  
S. Sawchuk ◽  
C. Zhang ◽  
...  
Keyword(s):  
Long Term Potentiation ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Specific Effects ◽  
Term Potentiation
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