Direct demonstration of interactions between substance P immunoreactive terminals and tyrosine hydroxylase immunoreactive neurons in the substantia nigra of the rat: An ultrastructural study

Synapse ◽  
1988 ◽  
Vol 2 (5) ◽  
pp. 508-515 ◽  
Author(s):  
Thomas J. Mahalik
Keyword(s):  
Tyrosine Hydroxylase ◽  
Substance P ◽  
Substantia Nigra ◽  
Ultrastructural Study ◽  
Direct Demonstration

The immunocytochemical localization of tyrosine hydroxylase in the human substantia nigra: An ultrastructural study

1997 ◽  
Vol 24 (1-2) ◽  
pp. 41 ◽  
Author(s):  
Rosalinda C. Roberts ◽  
Ross McKim ◽  
Lili Kung ◽  
Kristoffer Crosby ◽  
Dennis J. Chute
Keyword(s):  
Tyrosine Hydroxylase ◽  
Substantia Nigra ◽  
Ultrastructural Study ◽  
Immunocytochemical Localization ◽  
Human Substantia Nigra

scholarly journals Effects of Dopamine Denervation on Striatal Peptide Expression in Parkinsonian Monkeys

1991 ◽  
Vol 18 (S3) ◽  
pp. 373-375 ◽  
Author(s):  
Brigitte Lavoie ◽  
André Parent ◽  
Paul J. Bédard
Keyword(s):  
Tyrosine Hydroxylase ◽  
Substance P ◽  
Substantia Nigra ◽  
Calcium Binding ◽  
The Other ◽  
Substantia Nigra Pars Compacta ◽  
Systemic Injection ◽  
Cynomolgus Monkeys ◽  
Peptide Expression ◽  
Mptp Toxicity

ABSTRACT:In cynomolgus monkeys rendered parkinsonian by systemic injection of MPTP, severe cell losses were noted in the ventrolateral portion of the substantia nigra pars compacta (SNc), compared to a relative sparing of neurons in the ventral tegmental area (VTA) and dorsomedial portion of SNc. Most spared neurons in the SNc-VTA complex were found to contain the calcium binding protein calbindin (CaBP). At striatal levels the dopaminergic (DA) innervation, as visualized by tyrosine hydroxylase immunoreactivity, was markedly reduced in the ‘sensorimotor’ territory, variably affected in the ‘associative’ territory, and relatively well preserved in the ‘limbic’ territory. The immunoreactivity for enkephalin was enhanced and that for substance P was decreased in the sensorimotor territory, whereas the inverse was observed in the limbic territory. The distribution of the two peptides was highly heterogeneous in the associative territory. These findings suggest that the influence of the DA input on peptide expression varies from one striatal territory to the other, and that CaBP may protect midbrain DA neurons from MPTP toxicity.

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