Juvenile stress causes reduced locomotor behavior and dendritic spine density in the prefrontal cortex and basolateral amygdala in Sprague-Dawley rats

Synapse ◽  
2018 ◽  
Vol 73 (1) ◽  
pp. e22066 ◽  
Author(s):  
Cesar Pinzón-Parra ◽  
Blanca Vidal-Jiménez ◽  
Israel Camacho-Abrego ◽  
Alejandra A. Flores-Gómez ◽  
Antonio Rodríguez-Moreno ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dendritic Spine ◽  
Basolateral Amygdala ◽  
Locomotor Behavior ◽  
Spine Density ◽  
Sprague Dawley ◽  
Dendritic Spine Density ◽  
Sprague Dawley Rats

Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion

Synapse ◽  
2009 ◽  
Vol 63 (12) ◽  
pp. 1143-1153 ◽  
Author(s):  
Oscar Solis ◽  
Rubén Antonio Vázquez-Roque ◽  
Israel Camacho-Abrego ◽  
Citlalli Gamboa ◽  
Fidel De La Cruz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Spine Density ◽  
Amygdala Lesion ◽  
Dendritic Spine Density ◽  
Density Of Neurons

Lamina-Specific Reductions in Dendritic Spine Density in the Prefrontal Cortex of Subjects With Schizophrenia

2005 ◽  
Vol 162 (6) ◽  
pp. 1200-1202 ◽  
Author(s):  
Nutan Kolluri ◽  
Zhuoxin Sun ◽  
Allan R. Sampson ◽  
David A. Lewis
Keyword(s):  
Prefrontal Cortex ◽  
Dendritic Spine ◽  
Spine Density ◽  
Dendritic Spine Density

Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons

Synapse ◽  
2007 ◽  
Vol 61 (12) ◽  
pp. 978-984 ◽  
Author(s):  
Cecilia Flores ◽  
Xianglan Wen ◽  
Cassandre Labelle-Dumais ◽  
Bryan Kolb
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Dendritic Spine ◽  
Spine Density ◽  
Dendritic Spine Density

scholarly journals Developmental Stage-dependent Persistent Impact of Propofol Anesthesia on Dendritic Spines in the Rat Medial Prefrontal Cortex

2011 ◽  
Vol 115 (2) ◽  
pp. 282-293 ◽  
Author(s):  
Adrian Briner ◽  
Irina Nikonenko ◽  
Mathias De Roo ◽  
Alexandre Dayer ◽  
Dominique Muller ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Prefrontal Cortex ◽  
Developmental Stage ◽  
Medial Prefrontal Cortex ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Postnatal Life ◽  
Spine Density ◽  
Quantitative Electron Microscopy ◽  
Dendritic Spine Density

Background Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, however, to be explored. Methods Wistar rats received propofol anesthesia at defined developmental stages during early postnatal life. The acute and long-term effects of these treatments on neuronal cytoarchitecture were evaluated by Neurolucida and confocal microscopy analysis after iontophoretic injections of Lucifer Yellow into layer 5 pyramidal neurons in the medial prefrontal cortex. Quantitative electron microscopy was applied to investigate synapse density. Results Layer 5 pyramidal neurons of the medial prefrontal cortex displayed intense dendritic growth and spinogenesis during the first postnatal month. Exposure of rat pups to propofol at postnatal days 5 and 10 significantly decreased dendritic spine density, whereas this drug induced a significant increase in spine density when administered at postnatal days 15, 20, or 30. Quantitative electron microscopy revealed that the propofol-induced increase in spine density was accompanied by a significant increase in the number of synapses. Importantly, the propofol-induced modifications in dendritic spine densities persisted up to postnatal day 90. Conclusion These new results demonstrate that propofol anesthesia can rapidly induce significant changes in dendritic spine density and that these effects are developmental stage-dependent, persist into adulthood, and are accompanied by alterations in synapse number. These data suggest that anesthesia in the early postnatal period might permanently impair circuit assembly in the developing brain.

scholarly journals Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc

2019 ◽  
Author(s):  
Brendan B. McAllister ◽  
Sarah E. Thackray ◽  
Brenda Karina Garciá de la Orta ◽  
Elise Gosse ◽  
Purnoor Tak ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Knockout Mice ◽  
Environmental Enrichment ◽  
Basolateral Amygdala ◽  
Barrel Cortex ◽  
Zinc Transporter ◽  
Neuronal Morphology ◽  
Spine Density ◽  
Dendritic Length ◽  
Dendritic Spine Density

ABSTRACTIn the central nervous system, certain neurons store zinc within the synaptic vesicles of their axon terminals. This vesicular zinc can then be released in an activity-dependent fashion as an intercellular signal. The functions of vesicular zinc are not entirely understood, but evidence suggests that it is important for some forms of experience-dependent plasticity in the brain. The ability of neurons to store and release vesicular zinc is dependent on expression of the vesicular zinc transporter, ZnT3. Here, we examined the neuronal morphology of mice that lack ZnT3. Brains were collected from mice housed under standard laboratory conditions and from mice housed in enriched environments – large, multilevel enclosures with running wheels, numerous objects and tunnels, and a greater number of cage mates. Golgi-Cox staining was used to visualize neurons for analysis of dendritic length and dendritic spine density. Neurons were analyzed from the barrel cortex, striatum, basolateral amygdala, and hippocampus (CA1). ZnT3 knockout mice, relative to wild type mice, exhibited increased basal dendritic length in the layer 2/3 pyramidal neurons of barrel cortex, independently of housing condition. Environmental enrichment decreased apical dendritic length in these same neurons and increased dendritic spine density on striatal medium spiny neurons. Elimination of ZnT3 did not modulate any of the effects of enrichment. Our results provide no evidence that vesicular zinc is required for the experience-dependent changes that occur in response to environmental enrichment. They are consistent, however, with recent reports suggesting increased cortical volume in ZnT3 knockout mice.

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