Long-term effects of iloperidone on cerebral dopamine receptor subtypes

Synapse ◽  
2018 ◽  
Vol 72 (10) ◽  
pp. e22039 ◽  
Author(s):  
Yong Kee Choi ◽  
Frank I. Tarazi
Keyword(s):  
Dopamine Receptor ◽  
Receptor Subtypes ◽  
Long Term Effects ◽  
Dopamine Receptor Subtypes ◽  
Cerebral Dopamine

Long-term effects of cariprazine exposure on dopamine receptor subtypes

CNS Spectrums ◽  
2013 ◽  
Vol 19 (3) ◽  
pp. 268-277 ◽  
Author(s):  
Yong Kee Choi ◽  
Nika Adham ◽  
Béla Kiss ◽  
István Gyertyán ◽  
Frank I. Tarazi
Keyword(s):  
Dopamine Receptor ◽  
Dopaminergic System ◽  
Partial Agonist ◽  
Brain Regions ◽  
Repeated Treatment ◽  
Receptor Subtypes ◽  
Long Term Effects ◽  
Tissue Sections ◽  
Preferential Binding

IntroductionAll clinically effective antipsychotics are known to act on the dopaminergic system, and previous studies have demonstrated that repeated treatment with antipsychotics produced region-specific changes in dopamine receptor levels. Cariprazine is a dopamine D3 and D2 receptor partial agonist with preferential binding to D3 receptors. We examined the effects of chronic cariprazine administration on dopamine receptor levels.MethodsRats were administered either vehicle or cariprazine (0.06, 0.2, or 0.6 mg/kg) for 28 days. Dopamine receptor levels were quantitated using autoradiographic assays on brain tissue sections from the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), caudate putamen (CPu), hippocampus (HIPP), olfactory tubercle (OT), and islands of Calleja (ICj).ResultsChronic treatment with cariprazine did not alter D1 receptor levels in any brain region tested. Cariprazine increased D2 receptor levels in mPFC (27%–43%), NAc (40%–45%), medial (41%–53%) and lateral (52%–63%) CPu, and HIPP (38%). Cariprazine dose-dependently upregulated D3 receptor levels in ICj (32%–57%), OT (27%–67%), and NAc shell (31%–48%). Repeated cariprazine treatment increased D4 receptor in NAc (53%–82%), medial (54%–98%) and lateral (58%–74%) CPu, and HIPP (38%–98%).ConclusionSimilar to other antipsychotics, cariprazine upregulated D2 and D4 receptor levels in various brain regions. Cariprazine was unique among antipsychotics in increasing D3 receptor levels, which may support its unique psychopharmacologic properties.

Dopamine Receptor Subtypes and Orofacial Movement Topographies: Studies with Mutant Models

2010 ◽  
Vol 52 (4) ◽  
pp. 336-343
Author(s):  
Noriaki Koshikawa ◽  
Katsunori Tomiyama ◽  
John L. Waddington
Keyword(s):  
Dopamine Receptor ◽  
Receptor Subtypes ◽  
Dopamine Receptor Subtypes ◽  
Orofacial Movement

Effect of aging on striatal dopamine receptor subtypes in Wistar rats

1986 ◽  
Vol 7 (5) ◽  
pp. 357-361 ◽  
Author(s):  
Jacquelyn M. Henry ◽  
Charles R. Filburn ◽  
James A. Joseph ◽  
George S. Roth
Keyword(s):  
Dopamine Receptor ◽  
Wistar Rats ◽  
Striatal Dopamine ◽  
Receptor Subtypes ◽  
Dopamine Receptor Subtypes ◽  
Striatal Dopamine Receptor

Heterogeneity and regulation of central dopamine receptor subtypes studied by cDNA cloning methodology

1992 ◽  
Vol 20 ◽  
pp. 27-32 ◽  
Author(s):  
Pierre Sokoloff ◽  
Marie-Pascalle Martres ◽  
Bruno Giros ◽  
Marie-Louise Bouthenet ◽  
Jean-Charles Schwartz
Keyword(s):  
Dopamine Receptor ◽  
Cdna Cloning ◽  
Receptor Subtypes ◽  
Dopamine Receptor Subtypes

Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain

2009 ◽  
Vol 65 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Padmesh S. Rajput ◽  
Geetanjali Kharmate ◽  
Rishi K. Somvanshi ◽  
Ujendra Kumar
Keyword(s):  
Rat Brain ◽  
Dopamine Receptor ◽  
Receptor Subtypes ◽  
Dopamine Receptor Subtypes
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