Investigation of the role of alpha-2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats

Synapse ◽  
2016 ◽  
Vol 70 (12) ◽  
pp. 501-507 ◽  
Author(s):  
Ayse Ozcetin ◽  
Burcu Cevreli ◽  
Tayfun Uzbay
Keyword(s):  
Prepulse Inhibition ◽  
Adrenergic Receptors ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

Roles of the glutamate receptor ε2 and δ2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex

2001 ◽  
Vol 14 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Tomonori Takeuchi ◽  
Yuji Kiyama ◽  
Kazuhiro Nakamura ◽  
Mika Tsujita ◽  
Ikuo Matsuda ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Glutamate Receptor ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

scholarly journals Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92372 ◽  
Author(s):  
Sina Kohl ◽  
Carolin Wolters ◽  
Theo O. J. Gruendler ◽  
Kai Vogeley ◽  
Joachim Klosterkötter ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
High Functioning Autism ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex ◽  
High Functioning

Prepulse inhibition of the acoustic startle reflex in pigs and its disruption by d-amphetamine

2004 ◽  
Vol 155 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Nanna M. Lind ◽  
Sidse M. Arnfred ◽  
Ralf P. Hemmingsen ◽  
Axel K. Hansen
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

scholarly journals  Life-Course Contribution of Prenatal Stress in Regulating the Neural Modulation Network Underlying the Prepulse Inhibition of the Acoustic Startle Reflex in Male Alzheimer’s Disease Mice

2019 ◽  
Vol 30 (1) ◽  
pp. 311-325 ◽  
Author(s):  
Zahra Jafari ◽  
Bryan E Kolb ◽  
Majid H Mohajerani
Keyword(s):  
Prepulse Inhibition ◽  
Hpa Axis ◽  
Prenatal Stress ◽  
Acoustic Startle ◽  
Sensorimotor Gating ◽  
Startle Reflex ◽  
Underlying Mechanism ◽  
Acoustic Startle Reflex ◽  
Abnormal Development ◽  
Brain Areas

Abstract The prepulse inhibition (PPI) of the acoustic startle reflex (ASR), as an index of sensorimotor gating, is one of the most extensively used paradigms in the field of neuropsychiatric disorders. Few studies have examined how prenatal stress (PS) regulates the sensorimotor gating during the lifespan and how PS modifies the development of amyloid-beta (Aβ) pathology in brain areas underlying the PPI formation. We followed alternations in corticosterone levels, learning and memory, and the PPI of the ASR measures in APPNL-G-F/NL-G-F offspring of dams exposed to gestational noise stress. In-depth quantifications of the Aβ plaque accumulation were also performed at 6 months. The results indicated an age-dependent deterioration of sensorimotor gating, long-lasting PS-induced abnormalities in PPI magnitudes, as well as deficits in spatial memory. The PS also resulted in a higher Aβ aggregation predominantly in brain areas associated with the PPI modulation network. The findings suggest the contribution of a PS-induced hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in regulating the PPI modulation substrates leading to the abnormal development of the neural protection system in response to disruptive stimuli. The long-lasting HPA axis dysregulation appears to be the major underlying mechanism in precipitating the Aβ deposition, especially in brain areas contributed to the PPI modulation network.

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