Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area

Synapse ◽  
2016 ◽  
Vol 70 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Jodi L. Lukkes ◽  
Kevin J. Norman ◽  
Shirisha Meda ◽  
Susan L. Andersen
Keyword(s):  
Sex Differences ◽  
Ventral Tegmental Area ◽  
Adolescent Development ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Ventral Tegmental ◽  
Dorsal Raphé

scholarly journals Chronic methylphenidate treatment during adolescence has long-term effects on monoaminergic function

2018 ◽  
Vol 33 (1) ◽  
pp. 109-121 ◽  
Author(s):  
Mathieu Di Miceli ◽  
Adesina Omoloye ◽  
Benjamin Gronier
Keyword(s):  
Ventral Tegmental Area ◽  
Dorsal Raphe Nucleus ◽  
Late Adolescence ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Late Adolescent ◽  
Serotonin Neurons ◽  
Ventral Tegmental ◽  
Dorsal Raphé

Background: Psychostimulants like methylphenidate or D-amphetamine are often prescribed for attention deficit and hyperactivity disorders in children. Whether such drugs can be administered into a developing brain without consequences in adulthood is still an open question. Methods: Here, using in vivo extracellular electrophysiology in anesthetised preparations, combined with behavioural assays, we have examined the long-term consequences in adulthood of a chronic methylphenidate oral administration (5 mg/kg/day, 15 days) in early adolescent (post-natal day 28) and late adolescent (post-natal day 42) rats, by evaluating body weight change, sucrose preference (indicator of anhedonia), locomotor sensitivity to D-amphetamine and electrical activities of ventral tegmental area dopamine and dorsal raphe nucleus serotonin neurons. Results: Chronic methylphenidate treatment during early or late adolescence did not induce weight deficiencies and anhedonia-like behaviours at adulthood. However, it increased bursting activities of dorsal raphe nucleus serotonin neurons. Furthermore, chronic methylphenidate treatment during early but not during late adolescence enhanced D-amphetamine-induced rearing activity, as well as ventral tegmental area dopamine cell excitability (firing, burst and population activity), associated with a partial desensitisation of dopamine D2 auto-receptors. Conclusions: We have demonstrated here that early, but not late, adolescent exposure to oral methylphenidate may induce long-lasting effects on monoamine neurotransmission. The possible clinical implication of these data will be discussed.

scholarly journals Sex Differences in Corticotropin-Releasing Factor Receptor-1 Action Within the Dorsal Raphe Nucleus in Stress Responsivity

2014 ◽  
Vol 75 (11) ◽  
pp. 873-883 ◽  
Author(s):  
Alexis R. Howerton ◽  
Alison V. Roland ◽  
Jessica M. Fluharty ◽  
Anikò Marshall ◽  
Alon Chen ◽  
...  
Keyword(s):  
Sex Differences ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Corticotropin Releasing Factor ◽  
Stress Responsivity ◽  
Dorsal Raphé
Sign in / Sign up

Export Citation Format

Share Document