Peripheral markers of Alzheimer's disease: Surveillance of white blood cells

Synapse ◽  
2013 ◽  
Vol 67 (8) ◽  
pp. 541-543 ◽  
Author(s):  
Kaneez Fatima Shad ◽  
Yashar Aghazadeh ◽  
Sagheer Ahmad ◽  
Bodo Kress
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Cells ◽  
Disease Surveillance ◽  
White Blood Cells ◽  
Peripheral Markers

scholarly journals ABCA1-Labeled Exosomes in Serum Contain Higher MicroRNA-193b Levels in Alzheimer’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Chen-Geng Liu ◽  
Yue Zhao ◽  
Yao Lu ◽  
Pei-Chang Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Cells ◽  
White Blood Cells ◽  
Subjective Cognitive Decline ◽  
Control Group ◽  
Alzheimer Type ◽  
Primary Mouse ◽  
Study Participants ◽  
Serum Exosomes

Objective. We aimed to establish a method to determine whether microRNA-193b (miR-193b) levels in ABCA1-labeled serum exosomes might serve as a marker for the diagnosis of Alzheimer’s disease. Methods. We used immunocapture methods to determine the levels of ABCA1-labeled exosomal miR-193b in cultures of white blood cells (WBCs), red blood cells (RBCs), mouse hippocampal neuron HT-22 cells, and primary mouse neuronal cells. ABCA1-labeled exosomal miR-193b levels were also evaluated in the cerebrospinal fluid (CSF) and serum of APP/PS1 double-transgenic mice, as well as control subjects ( n = 60 ) and study participants with subjective cognitive decline (SCD, n = 89 ), stage and mild cognitive impairment (MCI, n = 92 ), and dementia of the Alzheimer type (DAT, n = 92 ). Results. ABCA1 levels of exosomes harvested from the medium of HT-22 cells and neurons were significantly higher than those of RBCs and WBCs ( P < 0.05 ). Exosomal ABCA1 from the CSF of APP/PS1 mice were transmitted to the serum of wild-type mice after injection, and high miR-193b levels were observed in both the serum and CSF after injection. The ABCA1-labeled exosomal miR-193b levels were higher in the CSF of MCI and DAT patients compared with the CSF of the control group ( P < 0.05 ). The ABCA1-labeled exosomal miR-193b were also slightly higher ( P > 0.05 ) in the serum of SCD patients and significantly higher in the serum of MCI and DAT patients compared with the serum of the control group ( P < 0.05 ). Conclusion. This study provides a method to capture specific exosomes. Detection of serum exosomes labeled with ABCA1 may facilitate the early diagnosis of AD.

Peripheral Markers and Diagnostic Criteria in Alzheimer's Disease: Critical Evaluations

1994 ◽  
Vol 5 (3) ◽  
Author(s):  
Eugenia S. de Lustig ◽  
Silvia Kohan ◽  
Arturo L. Famulari ◽  
Raul O. Dominguez ◽  
Jorge A. Serra
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diagnostic Criteria ◽  
Peripheral Markers

Interleukin-18 produced by peripheral blood cells is increased in Alzheimer’s disease and correlates with cognitive impairment

2008 ◽  
Vol 22 (4) ◽  
pp. 487-492 ◽  
Author(s):  
Paola Bossù ◽  
Antonio Ciaramella ◽  
Francesca Salani ◽  
Federica Bizzoni ◽  
Erika Varsi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Interleukin 18

P4-114: Small Chronic Alterations in Gene Expression and Circulating Blood Cells in Alzheimer's Disease

2010 ◽  
Vol 6 ◽  
pp. e56-e56
Author(s):  
Katie S. Lunnon ◽  
Haran Sivapalan ◽  
Amanda Vincent ◽  
Petroula Proitsi ◽  
Megan Pritchard ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Cells
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