Alzheimer's disease: β-amyloid plaque formation in human brain

Synapse ◽  
2011 ◽  
Vol 65 (12) ◽  
pp. 1289-1297 ◽  
Author(s):  
Philip Seeman ◽  
Neil Seeman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Brain ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Β Amyloid

scholarly journals Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer’s disease

2017 ◽  
Vol 26 (20) ◽  
pp. 4042-4054 ◽  
Author(s):  
Brijesh Kumar Singh ◽  
Naman Vatsa ◽  
Vipendra Kumar ◽  
Shashi Shekhar ◽  
Ankit Sharma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Model Of Alzheimer’S Disease

scholarly journals Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau

2021 ◽  
Author(s):  
Niklas Mattsson-Carlgren ◽  
Shorena Janelidze ◽  
Randall Bateman ◽  
Ruben Smith ◽  
Erik Stomrud ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medial Temporal Lobe ◽  
Amyloid Plaques ◽  
Amyloid Plaque ◽  
Amyloid Pet ◽  
Tau Pathology ◽  
Β Amyloid ◽  
Tau Pet ◽  
Disease Stages

Abstract Alzheimer’s disease is characterized by β-amyloid plaques and tau tangles. Plasma levels of phospho-tau217 (P-tau217) accurately differentiate Alzheimer’s disease dementia from other dementias, but it is unclear to what degree this reflects β-amyloid plaque accumulation, tau tangle accumulation, or both. In a cohort with post-mortem neuropathological data (N=88), both plaque and tangle density contributed independently to higher P-tau217. Several findings were replicated in a cohort with PET imaging (“BioFINDER-2”, N=426), where β-amyloid and tau PET were independently associated to P-tau217. P-tau217 correlated with β-amyloid PET (but not tau PET) in early disease stages, and with both β-amyloid and (more strongly) tau PET in late disease stages. Finally, P-tau217 mediated the association between β-amyloid and tau in both cohorts, especially for tau outside of the medial temporal lobe. These findings support the hypothesis that plasma P-tau217 is increased by both β-amyloid plaques and tau tangles and is congruent with the hypothesis that P-tau is involved in β-amyloid-dependent formation of neocortical tau tangles.

P2-241: Focal demyelination associated with amyloid plaque formation in Alzheimer's disease

2010 ◽  
Vol 6 ◽  
pp. S385-S385
Author(s):  
James Vickers ◽  
Stan Mitew ◽  
Matthew Kirkcaldie ◽  
Jerome Staal ◽  
Tracey Dickson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Focal Demyelination

scholarly journals Interactions between Amyloid-β and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33120 ◽  
Author(s):  
Jia-Ying Chuang ◽  
Chu-Wan Lee ◽  
Yao-Hsiang Shih ◽  
Tingting Yang ◽  
Lung Yu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Plaque ◽  
Plaque Formation

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

2017 ◽  
Vol 67 (4) ◽  
pp. 185-193 ◽  
Author(s):  
Reisuke H. Takahashi ◽  
Toshitaka Nagao ◽  
Gunnar K. Gouras
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Plaque Formation ◽  
Β Amyloid
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