scholarly journals Comparison of (+)-methamphetamine, ±-Methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze

Synapse ◽  
2010 ◽  
Vol 65 (5) ◽  
pp. 368-378 ◽  
Author(s):  
Charles V. Vorhees ◽  
Elizabeth He ◽  
Matthew R. Skelton ◽  
Devon L. Graham ◽  
Tori L. Schaefer ◽  
...  
Keyword(s):  
Water Maze ◽  
Cincinnati Water Maze

scholarly journals Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects

2019 ◽  
Vol 41 (1-2) ◽  
pp. 44-55 ◽  
Author(s):  
Sarah A. Jablonski ◽  
Michael T. Williams ◽  
Charles V. Vorhees
Keyword(s):  
Learning And Memory ◽  
Water Maze ◽  
High Dose ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Learning Deficits ◽  
Sprague Dawley Rats ◽  
Cincinnati Water Maze ◽  
Locomotor Deficits

Methamphetamine (MA) abuse is a worldwide issue that produces health and cognitive effects in the user. MA is abused by some women who then become pregnant and expose their developing child to the drug. Preclinical rodent models demonstrate cognitive deficits following developmental MA exposure, an effect observed in children exposed to MA in utero. To determine if the dopamine receptor D1 (DRD1) is involved in the learning and memory deficits following MA exposure, male Sprague-Dawley rats were treated 4 times daily at 2 h intervals with 0 (saline) or 10 mg/kg of MA from postnatal day (P)6–15, 30 min after 0.5, 1.0, or 2.0 mg/kg SCH23390. Cincinnati water maze testing began on P30, and the high dose of SCH23390 blocked the learning deficits induced by MA with no effect from the lower doses. Morris water maze (MWM) learning deficits following MA were not protected by SCH23390, although there was a non-dose dependent effect in the acquisition phase. Locomotor deficits induced by MA were reversed by all doses of SCH23390. There were no effects of MA on criterion to trial passive avoidance. Taken together, these data show that behaviors that are dependent on the striatum are better protected with the DRD1 antagonist during MA treatment than the hippocampally mediated spatial learning in the MWM. This suggests that multiple mechanisms exist for the deficits induced by neonatal MA administration.

Evaluation of cognitive functions in rats during toxicology studies: Validation study of cincinnati water maze

2007 ◽  
Vol 172 ◽  
pp. S185
Author(s):  
Olivier Foulon ◽  
Pauline Rousseau ◽  
Guillaume Froget ◽  
Roy Forster
Keyword(s):  
Validation Study ◽  
Cognitive Functions ◽  
Water Maze ◽  
Cincinnati Water Maze

Brain networks underlying navigation in the Cincinnati water maze with external and internal cues

2014 ◽  
Vol 576 ◽  
pp. 68-72 ◽  
Author(s):  
Natalia Arias ◽  
Marta Méndez ◽  
Jorge L. Arias
Keyword(s):  
Water Maze ◽  
Brain Networks ◽  
Cincinnati Water Maze
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