scholarly journals Methamphetamine induces striatal neurokinin-1 receptor endocytosis primarily in somatostatin/NPY/NOS interneurons and the role of dopamine receptors in mice

Synapse ◽  
2010 ◽  
Vol 65 (4) ◽  
pp. 300-308 ◽  
Author(s):  
Jing Wang ◽  
Jesus A. Angulo
Keyword(s):  
Dopamine Receptors ◽  
Neurokinin 1 Receptor ◽  
Receptor Endocytosis ◽  
Neurokinin 1

The Role of Substance P in the Marginal Division of the Neostriatum in Learning and Memory is Mediated Through the Neurokinin 1 Receptor in Rats

2011 ◽  
Vol 36 (10) ◽  
pp. 1896-1902 ◽  
Author(s):  
Xue-mei Liu ◽  
Si Yun Shu ◽  
Chang-chun Zeng ◽  
Ye-feng Cai ◽  
Kui-hua Zhang ◽  
...  
Keyword(s):  
Substance P ◽  
Learning And Memory ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Marginal Division

scholarly journals Elevated Neurokinin 1-Receptor Expression in uterine products of conception is associated with first trimester Miscarriages

2020 ◽  
Author(s):  
Riffat Mehboob ◽  
Syed Amir Gilani ◽  
Amber Hassan ◽  
Adeel Haider Tirmazi ◽  
Fridoon Jawad Ahmad ◽  
...  
Keyword(s):  
Substance P ◽  
First Trimester ◽  
Receptor Expression ◽  
Diagnostic Biomarkers ◽  
Neurokinin 1 Receptor ◽  
Products Of Conception ◽  
Mother’S Age ◽  
Neurokinin 1 ◽  
First Time

AbstractBackgroundMiscarriage is a common complication of early pregnancy, mostly occurring in first trimester. However, the etiological factors, prognostic and diagnostic biomarkers are not well known. Neurokinin-1 Receptor (NK-1R) is a receptor of tachykinin peptide, Substance P (SP) and has a role in various pathological conditions, cancers but it’s association with miscarriages and significance as a clinicopathological parameter is not studied. Accordingly, the present study aimed to clarify the localization and expression for NK-1R in human retained products of conception. Role of NK-1R is not known in miscarriages.Materials and MethodsNK-1R expression was assessed in products of conception by immunohistochemistry. Protein expression was evaluated using the nuclear labelling index (%).ResultsTen human products of conception tissues were studied by immunohistochemistry to demonstrate the localization of NK-1R. The expression of NK-1R protein was high in all the cases of POCs. NK-1R expression showed no notable differences among different cases of miscarriages irrespective of the mother’s age and gestational age at which the event occurred.ConclusionsExpression of NK-1R was similar in all the cases and it was intense. It shows that dysregulation of NK-1R along with its ligand Substance P might be involved in miscarriages. Our results provide fundamental data regarding this anti-NK-1R strategy. Thus, the present study recommends that SP/NK1R system might, therefore, be considered as an emerging and promising diagnostic and therapeutic strategy against miscarriages. Hence, we report for the first time, the expression and localization of NK-1R in products of conception. We suggest NK-1R antagonist in addition to the Immunoglobulins and Human chorionic gonadotropin, to diagnose and treat spontaneous miscarriages.

The Role of the Neurokinin-1 Receptor in Adhesion Formation and Prevention

2012 ◽  
Vol 172 (2) ◽  
pp. 340
Author(s):  
M.R. Cassidy ◽  
H.K. Sheldon ◽  
M.L. Gainsbury ◽  
H. Kosaka ◽  
A.F. Stucchi ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Role of kappa-opioids and neurokinin 1 receptor interactions on visceral nociception in a rat model

2003 ◽  
Vol 124 (4) ◽  
pp. A612
Author(s):  
Tobias Liebregts ◽  
Birgit Adam ◽  
Anton Bertel ◽  
Venus Eishabady ◽  
Guido Gerken ◽  
...  
Keyword(s):  
Rat Model ◽  
Neurokinin 1 Receptor ◽  
Kappa Opioids ◽  
Visceral Nociception ◽  
Receptor Interactions ◽  
Neurokinin 1
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