scholarly journals Dendritic-targeting GABA neurons in monkey prefrontal cortex: Comparison of somatostatin- and calretinin-immunoreactive axon terminals

Synapse ◽  
2008 ◽  
Vol 62 (6) ◽  
pp. 456-465 ◽  
Author(s):  
Darlene S. Melchitzky ◽  
David A. Lewis
Keyword(s):  
Prefrontal Cortex ◽  
Axon Terminals ◽  
Gaba Neurons ◽  
Monkey Prefrontal Cortex

scholarly journals Functional properties of GABA synaptic inputs onto GABA neurons in monkey prefrontal cortex

2015 ◽  
Vol 113 (6) ◽  
pp. 1850-1861 ◽  
Author(s):  
Diana C. Rotaru ◽  
Cameron Olezene ◽  
Takeaki Miyamae ◽  
Nadezhda V. Povysheva ◽  
Aleksey V. Zaitsev ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Input Resistance ◽  
Synaptic Inputs ◽  
Gaba Neurons ◽  
Decay Times ◽  
Cortical Interneurons ◽  
Dorsolateral Prefrontal ◽  
Gaba Neuron ◽  
Fast Spiking ◽  
Monkey Prefrontal Cortex

In rodent cortex GABAA receptor (GABAAR)-mediated synapses are a significant source of input onto GABA neurons, and the properties of these inputs vary among GABA neuron subtypes that differ in molecular markers and firing patterns. Some features of cortical interneurons are different between rodents and primates, but it is not known whether inhibition of GABA neurons is prominent in the primate cortex and, if so, whether these inputs show heterogeneity across GABA neuron subtypes. We thus studied GABAAR-mediated miniature synaptic events in GABAergic interneurons in layer 3 of monkey dorsolateral prefrontal cortex (DLPFC). Interneurons were identified on the basis of their firing pattern as fast spiking (FS), regular spiking (RS), burst spiking (BS), or irregular spiking (IS). Miniature synaptic events were common in all of the recorded interneurons, and the frequency of these events was highest in FS neurons. The amplitude and kinetics of miniature inhibitory postsynaptic potentials (mIPSPs) also differed between DLPFC interneuron subtypes in a manner correlated with their input resistance and membrane time constant. FS neurons had the fastest mIPSP decay times and the strongest effects of the GABAAR modulator zolpidem, suggesting that the distinctive properties of inhibitory synaptic inputs onto FS cells are in part conferred by GABAARs containing α1 subunits. Moreover, mIPSCs differed between FS and RS interneurons in a manner consistent with the mIPSP findings. These results show that in the monkey DLPFC GABAAR-mediated synaptic inputs are prominent in layer 3 interneurons and may differentially regulate the activity of different interneuron subtypes.

scholarly journals Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex

2009 ◽  
Vol 514 (4) ◽  
pp. 353-367 ◽  
Author(s):  
Dianne A. Cruz ◽  
Emily M. Lovallo ◽  
Steven Stockton ◽  
Matthew Rasband ◽  
David A. Lewis
Keyword(s):  
Prefrontal Cortex ◽  
Postnatal Development ◽  
Pyramidal Neuron ◽  
Synaptic Structure ◽  
Monkey Prefrontal Cortex ◽  
Axon Initial Segments
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