scholarly journals Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum

Synapse ◽  
2008 ◽  
Vol 62 (5) ◽  
pp. 325-336 ◽  
Author(s):  
Despina A. Tata ◽  
Bryan K. Yamamoto
Keyword(s):  
Chronic Stress ◽  
Rat Striatum ◽  
Extracellular Glutamate

Receptor binding properties of di (1,N6-ethenoadenosine) 5′, 5′′′-P1, P4-tetraphosphate and its modulatory effect on extracellular glutamate levels in rat striatum

2001 ◽  
Vol 309 (3) ◽  
pp. 177-180 ◽  
Author(s):  
Sol Oaknin ◽  
Carmen Rosa Rodrı́guez-Ferrer ◽  
José Santiago Aguilar ◽  
Antonio Ramos ◽  
Pedro Rotllán
Keyword(s):  
Receptor Binding ◽  
Rat Striatum ◽  
Extracellular Glutamate ◽  
Binding Properties

Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats

1997 ◽  
Vol 759 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Masaharu Shiraishi ◽  
Yoishiro Kamiyama ◽  
Peter Christian Hüttemeier ◽  
Helene Benveniste
Keyword(s):  
Synaptic Transmission ◽  
Rat Striatum ◽  
Extracellular Glutamate ◽  
Awake Rats

scholarly journals Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiao Cai ◽  
Chen Yang ◽  
Jin Chen ◽  
Weibo Gong ◽  
Faping Yi ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Chronic Mild Stress ◽  
Rat Striatum ◽  
Mild Stress ◽  
Absolute Quantitation ◽  
Protein Targets ◽  
Parallel Reaction Monitoring ◽  
Key Factor ◽  
Depression Disorders ◽  
Isobaric Tags

Chronic stress is a key factor for the onset of anxiety and depression disorders. However, the stress-induced common and unique molecular basis of the two psychiatric disorders is not fully known and still needs to be explored. Previously, we employed a chronic mild stress (CMS) procedure to induce a rat model including depression-susceptible (Dep-Sus), anxiety-susceptible (Anx-Sus), and insusceptible (Insus) cohorts. In this work, we continuously analyze the striatal proteomes of the three stressed cohorts by the use of comparative proteomics and bioinformatics approaches. Through isobaric tags for relative and absolute quantitation (iTRAQ)-based analysis, 386 abnormally expressed proteins in total were identified. These deregulated proteins are involved in various biological functions and significant pathways that are potentially connected with resistance and susceptibility to CMS-caused anxious- or depressive-like behaviors and, hence, could act as suggestive protein targets. A further parallel reaction monitoring-based independent investigation shows that alterations in Pak5, Dgkg, Scn4b, Rb1cc1, and Acin1; Ggps1, Fntb, Nudt19, Ufd1, and Ndufab1; and Dnajb12, Hbb2, Ap2s1, Ip6k1, and Stk4 were specifically connected with Dep-Sus, Anx-Sus, or Insus groups, respectively, potentially indicating that identical CMS treatment results in the different changes in the striatal protein regulations. Overall, our current proteomics study of the striatum provides an important molecular foundation and comprehensive insights into common and specific deregulations correlated with pathophysiological mechanisms that underlie resistance and susceptibility to chronic stress–induced anxiety or depression.

Extracellular glutamate changes in rat striatum during ischemia determined by a novel dialysis electrode and conventional microdialysis

2001 ◽  
Vol 39 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Megumi Sugahara ◽  
Satoshi Asai ◽  
Heng Zhao ◽  
Toshihito Nagata ◽  
Teruhito Kunimatsu ◽  
...  
Keyword(s):  
Rat Striatum ◽  
Extracellular Glutamate

scholarly journals Disruptions in the Regulation of Extracellular Glutamate by Neurons and Glia in the Rat Striatum Two Days after Diffuse Brain Injury

2012 ◽  
Vol 29 (6) ◽  
pp. 1197-1208 ◽  
Author(s):  
Jason M. Hinzman ◽  
Theresa Currier Thomas ◽  
Jorge E. Quintero ◽  
Greg A. Gerhardt ◽  
Jonathan Lifshitz
Keyword(s):  
Brain Injury ◽  
Rat Striatum ◽  
Extracellular Glutamate ◽  
Diffuse Brain Injury ◽  
Diffuse Brain

scholarly journals Changes in extracellular glutamate concentration produced in the rat striatum by repeated ischemia.

Stroke ◽  
1992 ◽  
Vol 23 (8) ◽  
pp. 1125-1130 ◽  
Author(s):  
Y Ueda ◽  
T P Obrenovitch ◽  
S Y Lok ◽  
G S Sarna ◽  
L Symon
Keyword(s):  
Rat Striatum ◽  
Extracellular Glutamate ◽  
Glutamate Concentration ◽  
Repeated Ischemia
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