Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice

Synapse ◽  
2007 ◽  
Vol 62 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Ji-Hoon Yoo ◽  
Yun-Sun Nam ◽  
Seok-Yong Lee ◽  
Choon-Gon Jang
Keyword(s):  
Receptor Antagonist ◽  
Locomotor Hyperactivity ◽  
Mdl 72222

MDL 72222, A SELECTIVE 5-HT3 RECEPTOR ANTAGONIST, SUPPRESSES VOLUNTARY ETHANOL CONSUMPTION IN ALCOHOL-PREFERRING RATS

1991 ◽  
Vol 26 (2) ◽  
pp. 107-110 ◽  
Author(s):  
FABIO FADDA ◽  
BRUNO GARAU ◽  
FRANCESCA MARCHEI ◽  
GIANCARLO COLOMBO ◽  
GIAN LUIGI GESSA
Keyword(s):  
Receptor Antagonist ◽  
Ethanol Consumption ◽  
Mdl 72222 ◽  
Voluntary Ethanol Consumption

Role of endogenous opioids and serotonin in the hemodynamic response to hemorrhage during hypoxia

1995 ◽  
Vol 269 (5) ◽  
pp. H1597-H1606 ◽  
Author(s):  
T. C. Resta ◽  
J. M. Resta ◽  
B. R. Walker
Keyword(s):  
Receptor Antagonist ◽  
Acute Hypoxia ◽  
Cardiovascular Responses ◽  
Endogenous Opioids ◽  
Receptor Subtype ◽  
Mdl 72222 ◽  
Hypoxic Conditions ◽  
Hemorrhage Volume ◽  
Serotonergic Receptor

Previous studies from our laboratory indicate that acute but not chronic hypoxia decreases the hemorrhage volume required to elicit reflex hypotension. Furthermore, chronically hypoxic animals exhibit an elevated hypotensive threshold during both normoxia and hypoxia compared with control animals. Because reports suggest that opioid and serotonergic mechanisms may be involved in mediating the sympathoinhibition that occurs with hemorrhage, we hypothesized that opioid and/or serotonergic systems are stimulated during hemorrhage under conditions of acute hypoxia and suppressed after chronic exposure to hypoxia and are thus responsible for the altered cardiovascular responses to hemorrhage under each condition. Control and chronically hypoxi rats were administered either the opioid receptor antagonist naltrexone (1 mg/kg), the selective 5-hydroxytryptamine receptor subtype 3 (5-HT3) serotonergic receptor antagonist MDL-72222 (0.5 mg/kg), or their respective vehicles intravenously before hemorrhage was initiated during normoxia or hypoxia (FIO2 = 0.12). In control animals, pretreatment with naltrexone increased the hemorrhage was initiated volume required to achieve hypotension in hypoxic but not normoxic conditions. Naltrexone had no effect on hypotensive threshold in chronically hypoxic animals under conditions of either normoxia or hypoxia. In addition, MDL-72222 had no effect on hypotensive threshold in either control or chronically hypoxic animals in either normoxic or hypoxic conditions. We conclude that endogenous opioids may contribute to the reflex hypotension that occurs during hypoxic hemorrhage in control rats, while no such involvement is evident in chronically hypoxic animals. Furthermore, peripheral 5-HT3 receptors are not likely involved in this response during either normoxic or hypoxic hemorrhage in control or chronically hypoxic rats.

Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures

1995 ◽  
Vol 133 (2) ◽  
pp. 251-254 ◽  
Author(s):  
Aldo E Calogero ◽  
Gyorgy Bagdy ◽  
Nunziatina Burrello ◽  
Pietro Polosa ◽  
Rosario D'Agata
Keyword(s):  
Pituitary Gland ◽  
Receptor Antagonist ◽  
Cell Cultures ◽  
Adrenocorticotropic Hormone ◽  
Pituitary Cell ◽  
Hormone Release ◽  
Mdl 72222 ◽  
Rat Pituitary ◽  
Ics 205 930 ◽  
Acth Release

Calogero AE, Bagdy G, Burrello N, Polosa P. D'Agata R. Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures. Eur J Endocrinol 1995;133:251–4. ISSN 0804–4643 Although several serotonin (5-HT) receptor types have been shown capable of stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, relatively little is known about the role of the 5-HT3 receptor, a receptor that has generated a great deal of interest for its involvement in many behavioral and therapeutic effects. Hence, in this study, we tested the effects of the 5-HT¾ receptor antagonist 3-tropanyl-indole-3-carboxylate (ICS 205-930) and the selective 5-HT3 receptor antagonist 3-tropanyl-3,5-dichlorobenzoate (MDL 72222) on ACTH release stimulated by 5-HT from primary cultures of rat pituitary cells. Subsequently, we evaluated the effects of the selective 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide (m-CPBG) on basal, corticotropin-releasing hormone (CRH)- and arginine vasopressin (AVP)-stimulated ACTH release. The maximal stimulatory effect of 5-HT (10−9 mol/l on ACTH release was antagonized by both ICS 205-930 and MDL 72222, suggesting that 5-HT stimulates basal ACTH release through activation of 5-HT3 receptors. Accordingly, m-CPBG stimulated basal ACTH release in a concentration-dependent fashion. In contrast to 5-HT, m-CPBG did not have any effect on CRH-stimulated ACTH release and inhibited AVP-stimulated ACTH release in a concentration-dependent manner. These data suggest that the 5-HT3 receptor is involved in the release of ACTH from the pituitary gland in vitro. Aldo E Calogero, Istituto di Clinica Medica I, Ospedale Garibaldi, Piazza S Maria di Gesú, 95123 Catania, Italy

Effects of a 5-HT3 receptor antagonist, MDL-72222, on morphine and cocaine stimulated elevation of extracellular dopamine

1994 ◽  
Vol 53 ◽  
pp. S223-S224 ◽  
Author(s):  
Pirjo Lillsunde ◽  
Aino Kivinen ◽  
Minna Mäkinen ◽  
Liisa Ahtee ◽  
Timo Seppälä
Keyword(s):  
Receptor Antagonist ◽  
Mdl 72222 ◽  
Extracellular Dopamine
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