The RNA-Binding Protein Unr Prevents Mouse Embryonic Stem Cells Differentiation Toward the Primitive Endoderm Lineage

Stem Cells ◽  
2011 ◽  
Vol 29 (10) ◽  
pp. 1504-1516 ◽  
Author(s):  
Habiba Elatmani ◽  
Virginie Dormoy-Raclet ◽  
Pierre Dubus ◽  
François Dautry ◽  
Claire Chazaud ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Primitive Endoderm

scholarly journals The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72300 ◽  
Author(s):  
Sharmila Fagoonee ◽  
Claudia Bearzi ◽  
Ferdinando Di Cunto ◽  
John G. Clohessy ◽  
Roberto Rizzi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Related Factors

RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells

2013 ◽  
Vol 40 (7) ◽  
pp. 4391-4396 ◽  
Author(s):  
Meghdad Yeganeh ◽  
Ehsan Seyedjafari ◽  
Farnaz Akbari Kamrani ◽  
Nasser Ghaemi
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

scholarly journals Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells

Cell Reports ◽  
2021 ◽  
Vol 35 (9) ◽  
pp. 109198
Author(s):  
Shlomi Dvir ◽  
Amir Argoetti ◽  
Chen Lesnik ◽  
Mark Roytblat ◽  
Kohava Shriki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem

scholarly journals Cold-Inducible RNA-Binding Protein Bypasses Replicative Senescence in Primary Cells through Extracellular Signal-Regulated Kinase 1 and 2 Activation

2009 ◽  
Vol 29 (7) ◽  
pp. 1855-1868 ◽  
Author(s):  
Ana Artero-Castro ◽  
Francisco B. Callejas ◽  
Josep Castellvi ◽  
Hiroshi Kondoh ◽  
Amancio Carnero ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Replicative Senescence ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem ◽  
Primary Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

ABSTRACT Embryonic stem cells are immortalized cells whose proliferation rate is comparable to that of carcinogenic cells. To study the expression of embryonic stem cell genes in primary cells, genetic screening was performed by infecting mouse embryonic fibroblasts (MEFs) with a cDNA library from embryonic stem cells. Cold-inducible RNA-binding protein (CIRP) was identified due to its ability to bypass replicative senescence in primary cells. CIRP enhanced extracellular signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation, and treatment with an MEK inhibitor decreased the proliferation caused by CIRP. In contrast to CIRP upregulation, CIRP downregulation decreased cell proliferation and resulted in inhibition of phosphorylated ERK1/2 inhibition. This is the first evidence that ERK1/2 activation, through the same mechanism as that described for a Val12 mutant K-ras to induce premature senescence, is able to bypass senescence in the absence of p16INK4a, p21WAF1, and p19ARF upregulation. Moreover, these results show that CIRP functions by stimulating general protein synthesis with the involvement of the S6 and 4E-BP1 proteins. The overall effect is an increase in kinase activity of the cyclin D1-CDK4 complex, which is in accordance with the proliferative capacity of CIRP MEFs. Interestingly, CIRP mRNA and protein were upregulated in a subgroup of cancer patients, a finding that may be of relevance for cancer research.

Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets

2006 ◽  
Vol 48 (6) ◽  
pp. 381-390 ◽  
Author(s):  
Tetsuya S. Tanaka ◽  
Isabel Lopez de Silanes ◽  
Lioudmila V. Sharova ◽  
Hidenori Akutsu ◽  
Toshiyuki Yoshikawa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem ◽  
Preimplantation Embryos ◽  
Rna Targets

The RNA-binding protein repertoire of embryonic stem cells

2013 ◽  
Vol 20 (9) ◽  
pp. 1122-1130 ◽  
Author(s):  
S Chul Kwon ◽  
Hyerim Yi ◽  
Katrin Eichelbaum ◽  
Sophia Föhr ◽  
Bernd Fischer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem

scholarly journals Canonical Wnt Signaling Induces a Primitive Endoderm Metastable State in Mouse Embryonic Stem Cells

Stem Cells ◽  
2013 ◽  
Vol 31 (4) ◽  
pp. 752-764 ◽  
Author(s):  
Feodor D. Price ◽  
Hang Yin ◽  
Andrew Jones ◽  
Wilfred van Ijcken ◽  
Frank Grosveld ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Metastable State ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Primitive Endoderm ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt
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