The Rho Kinase Pathway Regulates Mouse Adult Neural Precursor Cell Migration

Stem Cells ◽  
2011 ◽  
Vol 29 (2) ◽  
pp. 332-343 ◽  
Author(s):  
Soo Yuen Leong ◽  
Clare H. Faux ◽  
Alisa Turbic ◽  
Kirsty J. Dixon ◽  
Ann M. Turnley
Keyword(s):  
Cell Migration ◽  
Rho Kinase ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Kinase Pathway

scholarly journals The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Melanie Schoof ◽  
Michael Launspach ◽  
Dörthe Holdhof ◽  
Lynhda Nguyen ◽  
Verena Engel ◽  
...  
Keyword(s):  
Cell Migration ◽  
Intellectual Disability ◽  
Histone Acetyltransferase ◽  
Brain Size ◽  
Binding Protein ◽  
Neuronal Cell ◽  
Precursor Cell ◽  
Neuronal Morphology ◽  
Neural Precursor ◽  
Neural Precursor Cell

AbstractCREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutations within the CBP gene are known to cause Rubinstein-Taybi syndrome (RSTS), a developmental disorder characterized by intellectual disability, specific facial features and physical anomalies. Here, we investigate mechanisms of CBP function during brain development in order to elucidate morphological and functional mechanisms underlying the development of RSTS. Due to the embryonic lethality of conventional CBP knockout mice, we employed a tissue specific knockout mouse model (hGFAP-cre::CBPFl/Fl, mutant mouse) to achieve a homozygous deletion of CBP in neural precursor cells of the central nervous system.Our findings suggest that CBP plays a central role in brain size regulation, correct neural cell differentiation and neural precursor cell migration. We provide evidence that CBP is both important for stem cell viability within the ventricular germinal zone during embryonic development and for unhindered establishment of adult neurogenesis. Prominent histological findings in adult animals include a significantly smaller hippocampus with fewer neural stem cells. In the subventricular zone, we observe large cell aggregations at the beginning of the rostral migratory stream due to a migration deficit caused by impaired attraction from the CBP-deficient olfactory bulb. The cerebral cortex of mutant mice is characterized by a shorter dendrite length, a diminished spine number, and a relatively decreased number of mature spines as well as a reduced number of synapses.In conclusion, we provide evidence that CBP is important for neurogenesis, shaping neuronal morphology, neural connectivity and that it is involved in neuronal cell migration. These findings may help to understand the molecular basis of intellectual disability in RSTS patients and may be employed to establish treatment options to improve patients’ quality of life.

scholarly journals Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains

eNeuro ◽  
2019 ◽  
Vol 6 (6) ◽  
pp. ENEURO.0382-19.2019 ◽  
Author(s):  
Stephanie N. Iwasa ◽  
Abdolazim Rashidi ◽  
Elana Sefton ◽  
Nancy X. Liu ◽  
Milos R. Popovic ◽  
...  
Keyword(s):  
Cell Migration ◽  
Electrical Stimulation ◽  
Electric Fields ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression

2004 ◽  
Vol 57 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Khalid Shah ◽  
Emilie Bureau ◽  
Dong-Eog Kim ◽  
Katherine Yang ◽  
Yi Tang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Real Time ◽  
Tumor Regression ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Real Time Imaging

Regulation of adult neural precursor cell migration

2011 ◽  
Vol 59 (3) ◽  
pp. 382-393 ◽  
Author(s):  
Soo Yuen Leong ◽  
Ann M. Turnley
Keyword(s):  
Cell Migration ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

A Review of Bioreactor Protocols for Human Neural Precursor Cell Expansion in Preparation for Clinical Trials

2011 ◽  
Vol 6 (3) ◽  
pp. 229-254 ◽  
Author(s):  
Behnam A. Baghbaderani ◽  
Karim Mukhida ◽  
Murray Hong ◽  
Ivar Mendez ◽  
Leo A. Behie
Keyword(s):  
Clinical Trials ◽  
Cell Expansion ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development

2017 ◽  
Vol 64 (2) ◽  
pp. 287-299 ◽  
Author(s):  
Ciqing Yang ◽  
Xiaoying Li ◽  
Qiuling Li ◽  
Han Li ◽  
Liang Qiao ◽  
...  
Keyword(s):  
Cell Fate ◽  
Sonic Hedgehog ◽  
Optic Tectum ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Neural precursor cell influences on blood–brain barrier characteristics in rat brain endothelial cells

2007 ◽  
Vol 1159 ◽  
pp. 67-76 ◽  
Author(s):  
Joseph C. Lim ◽  
Adam J. Wolpaw ◽  
Maeve A. Caldwell ◽  
Stephen B. Hladky ◽  
Margery A. Barrand
Keyword(s):  
Endothelial Cells ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Precursor Cell ◽  
Brain Barrier ◽  
Neural Precursor ◽  
Brain Endothelial Cells ◽  
Neural Precursor Cell ◽  
Blood Brain ◽  
Rat Brain Endothelial Cells
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