Long-term survival of human myeloid progenitor cells induced by a mouse bone marrow stromal cell line

1992 ◽  
Vol 10 (3) ◽  
pp. 153-160 ◽  
Author(s):  
Takeshi Otsuka ◽  
Hironobu Satoh ◽  
Tomonori Ogo ◽  
Teruaki Nakano ◽  
Yoshiyuki Niho ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Mouse Bone Marrow ◽  
Term Survival ◽  
Marrow Stromal Cell ◽  
Myeloid Progenitor ◽  
Myeloid Progenitor Cells ◽  
Stromal Cell Line

A mouse bone marrow stromal cell line, TBR-B, shows inducible expression of smooth muscle-specific genes

FEBS Letters ◽  
2000 ◽  
Vol 481 (2) ◽  
pp. 193-196 ◽  
Author(s):  
Emi Arakawa ◽  
Kazuhide Hasegawa ◽  
Nobuaki Yanai ◽  
Masuo Obinata ◽  
Yuzuru Matsuda
Keyword(s):  
Bone Marrow ◽  
Smooth Muscle ◽  
Cell Line ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Inducible Expression ◽  
Mouse Bone Marrow ◽  
Marrow Stromal Cell ◽  
Stromal Cell Line

A Mouse Bone Marrow Stromal Cell Line with Skeletal Stem Cell Characteristics to Study Osteogenesis In Vitro and In Vivo

2014 ◽  
Vol 23 (10) ◽  
pp. 1097-1108 ◽  
Author(s):  
Sebastian Raeth ◽  
Benedetto Sacchetti ◽  
Georg Siegel ◽  
Ulrike A. Mau-Holzmann ◽  
Jan Hansmann ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Mouse Bone Marrow ◽  
Marrow Stromal Cell ◽  
Stromal Cell Line ◽  
Skeletal Stem Cell ◽  
Osteogenesis In Vitro

Differentiation potential of a mouse bone marrow stromal cell line

2003 ◽  
Vol 90 (1) ◽  
pp. 158-169 ◽  
Author(s):  
Elizabeth H. Allan ◽  
Patricia W.M. Ho ◽  
Akihro Umezawa ◽  
Jun-Ichi Hata ◽  
Fusao Makishima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Line ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Mouse Bone Marrow ◽  
Differentiation Potential ◽  
Marrow Stromal Cell ◽  
Stromal Cell Line

scholarly journals Improved hematopoiesis in anemic Sl/Sld mice by splenectomy and therapeutic transplantation of a hematopoietic microenvironment

Blood ◽  
1989 ◽  
Vol 74 (3) ◽  
pp. 1144-1151
Author(s):  
P Anklesaria ◽  
TJ FitzGerald ◽  
K Kase ◽  
A Ohara ◽  
JS Greenberger
Keyword(s):  
Bone Marrow ◽  
Cell Line ◽  
Hind Limb ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Volume Distribution ◽  
Distribution Analysis ◽  
Marrow Stromal Cell ◽  
Stromal Cell Line ◽  
The Right

The ability of a clonal hematopoiesis-supportive bone-marrow stromal cell line GBlneor to engraft and alter the microenvironment-induced anemia of Sl/Sld mice was studied. Prior to stromal cell transplantation, Sl/Sld mice received 1 Gy total body irradiation (TBI) and 13 Gy to the right hind limb. Two months after intravenous (IV) injection of 5 x 10(5) GBlneor cells, 54.4% +/- 17.0% donor origin (G418r) colony-forming cells were recovered from the right hind limb of Sl/Sld mice. Long-term bone marrow cultures (LTBMCs) established from GBlneor-transplanted mice produced 189.5 CFU-GEMM-forming progenitors/flask over 10 weeks compared with 52.7 +/- 6.2 CFU-GEMM forming progenitors/flask from irradiated nontransplanted Sl/Sld mice. A partial correction of macrocytic anemia was detected 2 months after GBlneor transplantation in splenectomized, irradiated Sl/Sld mice (HgB 7.2 +/- 0.4 g/dL; MCV 68.3 +/- 7.0 fL) compared to splenectomized, irradiated, nontransplanted Sl/Sld mice (HgB 5.5 +/- 1.1 g/dL; MCV 76 +/- 8.5 fL) or control Sl/Sld mice (HgB 5.4 +/- 0.5 g/dL; MCV 82.4 +/- 1.3 fL). Mean RBC volume distribution analysis showed a 2.5-fold increase in percentage of peripheral blood RBCs with MCV less than or equal to 45 fL and confirmed reduction of the MCV in splenectomized- GBlneor-transplanted mice compared to control Sl/Sld mice. A hematopoiesis-suppressive clonal stromal cell line derived from LTBMCs of Sl/Sld mice (Sldneor) engrafted as effectively (43.5% +/- 1.2% G418r CFU-F/limb) as did GBlneor cells (38.3% +/- 0.16% G418r CFU-F/limb) to the irradiated right hind limbs of C57Bl/6 mice. LTBMCs established after 2 or 6 months from Sldneor-transplanted mice showed decreased hematopoiesis (182 +/- 12 [2 months] and 3494.3 +/- 408.1 [6 months] CFU-GEMM forming progenitors/flask over 10 weeks) compared to those established from GBlneor-transplanted mice (5980 +/- 530 [2 months] and 7728 +/- 607, [6 months] CFU-GEMM progenitors forming/flask). Thus, transplantation of clonal bone-marrow stromal cell lines in vivo can stably transfer their physiologic properties to normal or mutant mice.

scholarly journals Expression of the c-kitligand and interleukin 6 genes in mouse bone marrow stromal cell lines

Stem Cells ◽  
1994 ◽  
Vol 12 (4) ◽  
pp. 409-415 ◽  
Author(s):  
Takeshi Otsuka ◽  
Tomonori Ogo ◽  
Teruaki Nakano ◽  
Hiroaki Niiro ◽  
Seiji Kuga ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Lines ◽  
Interleukin 6 ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Mouse Bone Marrow ◽  
Marrow Stromal Cell
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