Downregulation of augmenter of liver regeneration impairs the therapeutic efficacy of liver epithelial progenitor cells against acute liver injury by enhancing mitochondrial fission

Stem Cells ◽  
2021 ◽  
Vol 39 (11) ◽  
pp. 1546-1562
Author(s):  
Yuan Dong ◽  
Weining Kong ◽  
Wei An
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Progenitor Cells ◽  
Therapeutic Efficacy ◽  
Acute Liver Injury ◽  
Mitochondrial Fission ◽  
Augmenter Of Liver Regeneration ◽  
Epithelial Progenitor Cells

scholarly journals Augmenter of Liver Regeneration Protects Against Acetaminophen-Induced Acute Liver Injury in Mice by Promoting Autophagy

Shock ◽  
2019 ◽  
Vol 52 (2) ◽  
pp. 274-283 ◽  
Author(s):  
Ting Hu ◽  
Hang Sun ◽  
Wan-Yan Deng ◽  
Wen-Qi Huang ◽  
Qi Liu
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Acute Liver Injury ◽  
Augmenter Of Liver Regeneration

Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury

2007 ◽  
Vol 40 (4) ◽  
pp. 191-197 ◽  
Author(s):  
Hiroyuki Yoneyama ◽  
Yoshiro Kai ◽  
Jun Koyama ◽  
Kenji Suzuki ◽  
Hiroshi Kawachi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Liver Regeneration ◽  
Acute Liver Injury

scholarly journals Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Lixiang Wang ◽  
Xin Li ◽  
Yuki Hanada ◽  
Nao Hasuzawa ◽  
Yoshinori Moriyama ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Er Stress ◽  
Disease Progression ◽  
Acute Liver Injury ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Fission ◽  
Mitochondrial Fusion ◽  
Related Protein ◽  
Liver Disease Progression

AbstractMitochondrial fusion and fission, which are strongly related to normal mitochondrial function, are referred to as mitochondrial dynamics. Mitochondrial fusion defects in the liver cause a non-alcoholic steatohepatitis-like phenotype and liver cancer. However, whether mitochondrial fission defect directly impair liver function and stimulate liver disease progression, too, is unclear. Dynamin-related protein 1 (DRP1) is a key factor controlling mitochondrial fission. We hypothesized that DRP1 defects are a causal factor directly involved in liver disease development and stimulate liver disease progression. Drp1 defects directly promoted endoplasmic reticulum (ER) stress, hepatocyte death, and subsequently induced infiltration of inflammatory macrophages. Drp1 deletion increased the expression of numerous genes involved in the immune response and DNA damage in Drp1LiKO mouse primary hepatocytes. We administered lipopolysaccharide (LPS) to liver-specific Drp1-knockout (Drp1LiKO) mice and observed an increased inflammatory cytokine expression in the liver and serum caused by exaggerated ER stress and enhanced inflammasome activation. This study indicates that Drp1 defect-induced mitochondrial dynamics dysfunction directly regulates the fate and function of hepatocytes and enhances LPS-induced acute liver injury in vivo.

Loss of hepatic miR-194 promotes liver regeneration and protects from acetaminophen-induced acute liver injury

2021 ◽  
pp. 114862
Author(s):  
Yi-Ming Chang ◽  
Po-Chun Chen ◽  
Chien-Peng Hsu ◽  
Peng-Fang Ma ◽  
Huey-Ling Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Acute Liver Injury

scholarly journals Oroxylin A Accelerates Liver Regeneration in CCI4-Induced Acute Liver Injury Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71612 ◽  
Author(s):  
Runzhi Zhu ◽  
Guofang Zeng ◽  
Yinqin Chen ◽  
Qingyu Zhang ◽  
Bin Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Acute Liver Injury ◽  
Oroxylin A

scholarly journals Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice

Oncotarget ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 12637-12648 ◽  
Author(s):  
Hongbo Shi ◽  
Weijia Han ◽  
Honglin Shi ◽  
Feng Ren ◽  
Dexi Chen ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Liver Regeneration ◽  
Augmenter Of Liver Regeneration

scholarly journals Resina Draconis Reduces Acute Liver Injury and Promotes Liver Regeneration after 2/3 Partial Hepatectomy in Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Zhi-yong He ◽  
Kai-han Lou ◽  
Jia-hui Zhao ◽  
Ming Zhang ◽  
Lan-chun Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Acute Liver Injury ◽  
Liver Weight ◽  
Nuclear Antigen ◽  
Protective Effects ◽  
Weight Restoration ◽  
Resina Draconis ◽  
Proliferating Cell

Aim. To investigate the protective effects and possible mechanisms of action of resina draconis (RD) on acute liver injury and liver regeneration after 2/3 partial hepatectomy (PH) in mice. Methods. 2/3 PH was used to induce acute liver injury. Mice were divided into three groups: sham, vehicle + 2/3 PH, and RD + 2/3 PH. Resina draconis was administered intragastrically after 2/3 PH into the RD + 2/3 PH group, and the same volume of vehicle (1% sodium carboxymethyl cellulose) was injected into the vehicle + 2/3 PH group and sham group mice. The index of liver to body weight (ILBW) and proliferating cell nuclear antigen (PCNA) were assayed to evaluate liver regeneration. Blood and liver tissues were collected for serological and western blotting analysis. Results. Resina draconis protected against 2/3 PH-induced acute severe liver injury and promoted liver regeneration as shown by significantly increased ILBW compared with that of controls. 2/3 PH increased serum AST and ALT levels, which were significantly decreased by RD treatment, while 2/3 PH decreased serum TP and ALB, which were increased by RD treatment. In the RD + 2/3 PH group, PCNA expression was significantly increased compared with the 2/3 PH group. Further, hepatocyte growth factor (HGF), TNFα, and EGFR levels were increased in the RD group at postoperative days 2 and 4 compared with the those in the 2/3 PH group. Conclusion. Our results suggest that RD ameliorates acute hepatic injury and promotes liver cell proliferation, liver weight restoration, and liver function after 2/3 PH, probably via HGF, TNFα, and EGFR signaling.

Sign in / Sign up

Export Citation Format

Share Document