scholarly journals Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel

Stem Cells ◽  
2010 ◽  
Vol 28 (4) ◽  
pp. 649-660 ◽  
Author(s):  
Christina H. Stuelten ◽  
Susan D. Mertins ◽  
Johanna I. Busch ◽  
Meghan Gowens ◽  
Dominic A. Scudiero ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Tumor Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cell Line Panel ◽  
Complex Display

Abstract 3372: Analysis of putative tumor stem cell markers in the NCI-60 tumor cell line panel

2010 ◽  
Author(s):  
Christina H. Stuelten ◽  
Susan D. Mertins ◽  
Johanna I. Busch ◽  
Meghan Gowens ◽  
Dominic A. Scudiero ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Tumor Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cell Line Panel

scholarly journals Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Laura L. Stafman ◽  
Adele P. Williams ◽  
Raoud Marayati ◽  
Jamie M. Aye ◽  
Hooper R. Markert ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Cell ◽  
Cell Survival ◽  
Cell Lines ◽  
Human Condition ◽  
Migration And Invasion ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cycle Arrest

Abstract Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely resembles the human condition than that seen with long-term passage cell lines. In the current studies, we investigated the effects of FAK inhibition on two neuroblastoma PDXs in vitro. Cells were treated with two small molecule inhibitors of FAK, PF-573,228 (PF) and 1,2,4,5-benzentetraamine tetrahydrochloride (Y15). Following FAK inhibition, cell survival and proliferation decreased significantly and cell cycle arrest was seen in both cell lines. Migration and invasion assays were used to determine the effect of FAK inhibition on cell motility, which decreased significantly in both cell lines in the presence of either inhibitor. Finally, tumor cell stemness following FAK inhibition was evaluated with extreme limiting dilution assays as well as with immunoblotting and quantitative real-time PCR for the expression of stem cell markers. FAK inhibition decreased formation of tumorspheres and resulted in a corresponding decrease in established stem cell markers. FAK inhibition decreased many characteristics of the malignant phenotype, including cancer stem cell like features in neuroblastoma PDXs, making FAK a candidate for further investigation as a potential target for neuroblastoma therapy.

A comprehensive 16 loci-based DNA fingerprinting dataset of a broad tumor cell line panel for cancer research

2012 ◽  
Vol 18 (A) ◽  
pp. 77
Author(s):  
A Somaschini ◽  
E Scacheri ◽  
A Nuzzo ◽  
N Amboldi ◽  
D Ballinari ◽  
...  
Keyword(s):  
Cancer Research ◽  
Tumor Cell ◽  
Cell Line ◽  
Dna Fingerprinting ◽  
Tumor Cell Line ◽  
Cell Line Panel

Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche?

Pituitary ◽  
2013 ◽  
Vol 17 (6) ◽  
pp. 546-556 ◽  
Author(s):  
Annett Hölsken ◽  
Christina Stache ◽  
Sven Martin Schlaffer ◽  
Jörg Flitsch ◽  
Rudolf Fahlbusch ◽  
...  
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Stem Cell Niche ◽  
Tumor Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cell Niche ◽  
In Cells

518 IDENTIFICATION OF TUMOR STEM CELL MARKERS IN TRP53 DELETED LIVER TUMORS

2009 ◽  
Vol 50 ◽  
pp. S193
Author(s):  
A. Lechel ◽  
D. Hartmann ◽  
S.-F. Katz ◽  
Y. Begus-Nahrmann ◽  
P. Schirmacher ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Tumors ◽  
Tumor Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers
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